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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
5'-adenylic phosphatase, 5'-AMP nucleotidase, 5'-AMPase, 5'-ectonucleotidase, 5'-mononucleotidase, 5'-NT, 5'-NT-1, 5'-NT-2, 5'-NT-3, 5'-NT-4,
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5'-adenylic phosphatase
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5'-AMP nucleotidase
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5'-mononucleotidase
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adenosine 5'-monophosphatase
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adenosine 5'-phosphatase
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adenosine monophosphatase
AMP phosphohydrolase
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AMP-selective 5'-nucleotidase
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CD73/ecto-5'-nucleotidase
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class C acid phosphatase
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cytoplasmic 5'-nucleotidase II
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cytoplasmic 5'-nucleotidase II (IMP-selective or GMP/IMP-selective)
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cytoplasmic 5'-nucleotidase III
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cytoplasmic 5'-nucleotidase-I (AMP-selective)
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cytosolic 5'-nucleotidase
cytosolic 5'-nucleotidase II
cytosolic 5'-nucleotidase/phosphotransferase
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ecto-5'-nucleotidase/CD73
ectonucleotidase CD73
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high Km 5'-nucleotidase
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IMP 5'-nucleotidase
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IMP-GMP specific nucleotidase
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IMP-specific, high Km 5'-nucleotidase
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IMP/GMP selective 5'-NT
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membrane-bound 5'-nucleotidase
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purine 5'-nucleotidase
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pyrimidine 5'-nucleotidase
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snake venom 5'-nucleotidase
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soluble calcium-activated nucleotidase 1
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thymidine monophosphate nucleotidase
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type II cytosolic 5'-nucleotidase
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uridine 5'-nucleotidase
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uridine monophosphate hydrolase-1
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5'-NT
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5'-nucleotidase
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5'-nucleotidase A
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5'nucleotidase
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5nA
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adenosine monophosphatase
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adenosine monophosphatase
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AMPase
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CD73
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CD73
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a bifunctional glycosylphosphatidylinositol-anchored membrane protein which functions as ecto-5'-nucleotidase and a membrane receptor for extracellular matrix protein
cN-I
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cN-I
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has a high affinity for both nucleoside and deoxynucleoside monophosphates, the latter, however, are converted with a much lower rate
cN-II
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cN-III
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cytosolic 5'-nucleotidase
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cytosolic 5'-nucleotidase
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cytosolic 5'-nucleotidase II
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cytosolic 5'-nucleotidase II
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e-5NT
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e5'NT
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ecto 5'-nucleotidase
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ecto-5'-NT
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ecto-5'-NT/CD73
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ecto-5'-nucleotidase
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ecto-5'-nucleotidase
Bothrops pradoi
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ecto-5'-nucleotidase
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677490 , 677542 , 678104 , 681724 , 691398 , 692192 , 694138 , 707133 , 708576 , 709460 , 709469 , 710524 , 715987 , 750661 , 752167
ecto-5'-nucleotidase/CD73
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ecto-5'-nucleotidase/CD73
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ecto-5'-nucleotidase/CD73
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ecto-5'-nucleotidase/CD73
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ecto-5'nucleotidase
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ecto-nucleotidase
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ectonucleotidase
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eNT
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IMP-GMP 5'-nucleotidase
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IMP-GMP 5'-nucleotidase
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IMP-GMP 5'-nucleotidase
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NT5C3A
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NT5E
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Phm8
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Sdt1
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UshA
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XF_2089
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YutF
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additional information
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the enzyme belongs to the the 5'-nucleotidase family
additional information
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cytosolic 5'-nucleotidases are members of the haloacid dehalogenase superfamily. CD73 belongs to a conserved superfamily of metallophosphodiesterases
additional information
cN-II is a relatively large enzyme of the structural HAD superfamily
additional information
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the Isn1 polypeptide is a member of the HAD superfamily
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a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate
a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate
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a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate
conserved motif I is involved in formation and stabilization of the covalent enzyme-phosphate intermediate. T249 and K292 in motif II contribute to stabilize the enzyme-phospho adduct. D351 and D356 in motif III coordinate the magnesium ion required for catalysis
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hydrolysis of phosphoric ester
hydrolysis of phosphoric esters
phosphorous acid anhydride hydrolysis
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hydrolysis of phosphoric ester
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hydrolysis of phosphoric ester
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hydrolysis of phosphoric esters
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hydrolysis of phosphoric esters
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5'-ribonucleotide phosphohydrolase
Wide specificity for 5'-nucleotides.
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3.1.3.5 5'-nucleotidase
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