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Synonyms
5'-nucleotidase, ecto-5'-nucleotidase, ectonucleotidase, 5'nucleotidase, 5'-nt, cn-ii, ecto-nucleotidase, pyrimidine 5'-nucleotidase, cytosolic 5'-nucleotidase, ampase,
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5'-adenylic phosphatase
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5'-AMP nucleotidase
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5'-mononucleotidase
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adenosine 5'-monophosphatase
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adenosine 5'-phosphatase
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adenosine monophosphatase
AMP phosphohydrolase
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AMP-selective 5'-nucleotidase
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CD73/ecto-5'-nucleotidase
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class C acid phosphatase
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cytoplasmic 5'-nucleotidase II
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cytoplasmic 5'-nucleotidase II (IMP-selective or GMP/IMP-selective)
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cytoplasmic 5'-nucleotidase III
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cytoplasmic 5'-nucleotidase-I (AMP-selective)
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cytosolic 5'-nucleotidase
cytosolic 5'-nucleotidase II
cytosolic 5'-nucleotidase/phosphotransferase
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ecto-5'-nucleotidase/CD73
ectonucleotidase CD73
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high Km 5'-nucleotidase
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IMP 5'-nucleotidase
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IMP-GMP specific nucleotidase
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IMP-specific, high Km 5'-nucleotidase
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IMP/GMP selective 5'-NT
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membrane-bound 5'-nucleotidase
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purine 5'-nucleotidase
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pyrimidine 5'-nucleotidase
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snake venom 5'-nucleotidase
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soluble calcium-activated nucleotidase 1
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thymidine monophosphate nucleotidase
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type II cytosolic 5'-nucleotidase
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uridine 5'-nucleotidase
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uridine monophosphate hydrolase-1
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5'-NT
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5'-nucleotidase
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5'-nucleotidase A
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5'nucleotidase
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5nA
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adenosine monophosphatase
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adenosine monophosphatase
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AMPase
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CD73
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CD73
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a bifunctional glycosylphosphatidylinositol-anchored membrane protein which functions as ecto-5'-nucleotidase and a membrane receptor for extracellular matrix protein
cN-I
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cN-I
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has a high affinity for both nucleoside and deoxynucleoside monophosphates, the latter, however, are converted with a much lower rate
cN-II
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cN-III
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cytosolic 5'-nucleotidase
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cytosolic 5'-nucleotidase
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cytosolic 5'-nucleotidase II
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cytosolic 5'-nucleotidase II
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e-5NT
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e5'NT
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ecto 5'-nucleotidase
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ecto 5'-nucleotidase
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ecto-5'-NT
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ecto-5'-NT/CD73
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ecto-5'-nucleotidase
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ecto-5'-nucleotidase
Bothrops pradoi
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ecto-5'-nucleotidase
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ecto-5'-nucleotidase
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ecto-5'-nucleotidase
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677490, 677542, 678104, 681724, 691398, 692192, 694138, 707133, 708576, 709460, 709469, 710524, 715987, 750661, 752167
ecto-5'-nucleotidase
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ecto-5'-nucleotidase
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ecto-5'-nucleotidase
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ecto-5'-nucleotidase
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ecto-5'-nucleotidase/CD73
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ecto-5'-nucleotidase/CD73
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ecto-5'-nucleotidase/CD73
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ecto-5'-nucleotidase/CD73
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ecto-5'nucleotidase
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ecto-nucleotidase
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ectonucleotidase
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eNT
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IMP-GMP 5'-nucleotidase
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IMP-GMP 5'-nucleotidase
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IMP-GMP 5'-nucleotidase
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NT5C3A
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NT5E
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Phm8
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Sdt1
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UshA
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XF_2089
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YutF
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additional information
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the enzyme belongs to the the 5'-nucleotidase family
additional information
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cytosolic 5'-nucleotidases are members of the haloacid dehalogenase superfamily. CD73 belongs to a conserved superfamily of metallophosphodiesterases
additional information
cN-II is a relatively large enzyme of the structural HAD superfamily
additional information
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the Isn1 polypeptide is a member of the HAD superfamily
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(polyphosphate)n + H2O
(polyphosphate)(n-1) + phosphate
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?
(polyphosphate)n + H2O
(polyphosphate)n-1 + phosphate
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?
1,N6-ethenoadenosine 5'-phosphate + H2O
1,N6-ethenoadenosine ribonucleoside + phosphate
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45% of the activity with 5'-AMP, heart, membrane-bound enzyme
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?
1-glycerophosphate + H2O
glycerol + phosphate
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1% of the activity with 5-IMP
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?
2'-chloro-2'-deoxyAMP + H2O
2'-chloro-2'-deoxyadenosine + phosphate
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cNII
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?
2-(cyclohexylethylthio)adenosine 5'-monophosphate + H2O
2-(cyclohexylethylthio)adenosine + phosphate
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?
2-(cyclohexylmethylthio)adenosine 5'-monophosphate + H2O
2-(cyclohexylmethylthio)adenosine + phosphate
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?
2-(cyclohexylthio)adenosine 5'-monophosphate + H2O
2-(cyclohexylthio)adenosine + phosphate
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?
2-(cyclopentylthio)adenosine 5'-monophosphate + H2O
2-(cyclopentylthio)adenosine + phosphate
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2-(dioxanylethylthio)adenosine 5'-monophosphate + H2O
2-(dioxanylethylthio)adenosine + phosphate
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2-(dioxolanylethylthio)adenosine 5'-monophosphate + H2O
2-(dioxolanylethylthio)adenosine + phosphate
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2-(hexylthio)adenosine 5'-monophosphate + H2O
2-(hexylthio)adenosine + phosphate
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2-(propylthio)adenosine 5'-monophosphate + H2O
2-(propylthio)adenosine + phosphate
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2-chloro-2'-deoxyadenosine monophosphate + H2O
2-chloro-2'-deoxyadenosine + phosphate
39% of the activity with 5'-AMP
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3'-AMP + H2O
adenosine + phosphate
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3'-azido-3'deoxy-dTMP + H2O
3'-azido-3'-deoxythymidine + phosphate
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cNII
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3'-CMP + H2O
cytosine + phosphate
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3'-IMP + H2O
inosine + phosphate
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1% of the activity with 5'-IMP
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3-beta-ribofuranosyladenine 5'-monophosphate + H2O
3-beta-ribofuranosyladenine + phosphate
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24% of the activity with 5'-AMP, heart, membrane-bound enzyme
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4-methylumbelliferyl phosphate + H2O
4-methylumbelliferol + phosphate
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4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
5'-ADP + H2O
AMP + phosphate
very low activity
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5'-AMP + H2O
adenosine + phosphate
5'-ATP + H2O
ADP + phosphate
very low activity
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5'-CMP + H2O
cytidine + phosphate
5'-CMP + xanthosine
XMP + cytidine
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5'-CTP + H2O
CDP + phosphate
low activity
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?
5'-dAMP + H2O
deoxyadenosine + phosphate
5'-dCMP + H2O
2'-deoxycytidine + phosphate
5'-dCMP + H2O
deoxycytidine + phosphate
5'-dGMP + H2O
deoxyguanosine + phosphate
5'-dIMP + H2O
deoxyinosine + phosphate
5'-dTMP + H2O
deoxythymidine + phosphate
5'-dUMP + H2O
deoxyuridine + phosphate
5'-GDP + H2O
GMP + phosphate
very low activity
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5'-GMP + H2O
guanosine + phosphate
5'-GMP + xanthosine
XMP + guanosine
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5'-GTP + H2O
GDP + phosphate
very low activity
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5'-IDP + H2O
IMP + phosphate
very low activity
3.1.3.5 5'-nucleotidase
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