Any feedback?
Information on EC 5.3.99.3 - prostaglandin-E synthase
for references in articles please use BRENDA:EC5.3.99.3Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
5.3.99.3 prostaglandin-E synthaseIUBMB Comments
Brings about the opening of the epidioxy bridge. Requires glutathione.
Specify your search results
Word Map
- 5.3.99.3
- cox-2
-
cyclooxygenase
-
arachidonic
- synthases
-
prostanoids
- lipopolysaccharide
- tnf
- lps
- phospholipase
-
eicosanoids
-
lps-induced
- pain
- endometrium
-
leukotriene
- prostacyclin
-
thromboxane
-
nsaids
- indomethacin
-
pgf2alpha
-
5-lipoxygenase
- il-1beta
- celecoxib
-
nonsteroidal
- interleukin-1beta
-
luteolysis
- luteal
- platinum
- 15-pgdh
-
estrous
-
postictal
- medicine
-
rhodium
-
pencil
- palladium
- drug development
-
6-keto-pgf1alpha
-
automobile
- pghs-2
-
prostaglandin-endoperoxide
-
e-prostanoid
-
ictal
-
pge2-dependent
- l-pgds
- 15-hydroxyprostaglandin
-
lipocalin-type
- akr1b1
-
cox-2-dependent
-
6-keto
-
coxibs
-
6-keto-pgf1
- ptgds
-
cox-derived
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
=
Synonyms
mpges-1, pges, microsomal prostaglandin e synthase-1, mpges, pge synthase, ptges, prostaglandin e synthase, mpges-2, cpges, mpges1, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CPGES
cPGES/p23
cytosolic prostaglandin E synthase
cytosolic prostaglandin E(2) synthase-2
endoperoxide isomerase
-
-
-
-
Isomerase, prostaglandin R2 E-
-
-
-
-
microsomal PGE2 synthase-1
microsomal prostaglandin E synthase 1
microsomal prostaglandin E synthase-1
microsomal prostaglandin E synthase-2
microsomal prostaglandin E(2) synthase-1
microsomal prostaglandin E(2) synthase-2
microsomal prostaglandin E2 synthase-1
mPGES
mPGES-1
mPGES-2
MPGES1
MPGES2
p23
PGE isomerase
-
-
-
-
PGE synthase
PGE2
PGE2 isomerase
-
-
-
-
PGES
PGES-2
PGH-PGE isomerase
-
-
-
-
PGH2/PGE2 isomerase
-
-
-
-
prostagandin-E synthetase
-
-
-
-
Prostaglandin E synthase
prostaglandin E synthase 1
prostaglandin E synthase-1
prostaglandin E synthase-2
Prostaglandin E2 isomerase
-
-
-
-
prostaglandin E2 synthase
Prostaglandin endoperoxide E isomerase
-
-
-
-
Prostaglandin endoperoxide E2 isomerase
-
-
-
-
Prostaglandin endoperoxide-E isomerase
-
-
-
-
Prostaglandin H-E isomerase
-
-
-
-
Prostaglandin H-prostaglandin E isomerase
-
-
-
-
Prostaglandin R-prostaglandin E isomerase
-
-
-
-
Prostaglandin-H2 E-isomerase
-
-
-
-
PTGES
microsomal prostaglandin E synthase-1
-
-
microsomal prostaglandin E synthase-1
-
microsomal prostaglandin E synthase-1
-
-
microsomal prostaglandin E synthase-1
-
-
microsomal prostaglandin E2 synthase-1
-
-
mPGES-1
-
-
mPGES-1
-
mPGES-1
-
-
Prostaglandin E synthase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate = (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate
-
-
-
-
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
catalytic mechanism of mPGES-2, hydrogen bond-forming residues Y107, C113, C110, and F112 are involved, substrate binding and catalytic sites
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
intramolecular oxidation
-
-
-
-
isomerization
isomerization
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
(5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase
Brings about the opening of the epidioxy bridge. Requires glutathione.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
52227-79-9
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(5Z,13E)-(15S)-9a,11a-epidioxy-15-hydroxyprosta-5,13-dienoate + GSH
(5Z,13E)-(15S)-11a,15-dihydroxyprosta-5,13-dienoate + GSSG
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + GSH
(5Z,13E)-(15S)-11alpha,15-dihydroxyprosta-5,13-dienoate + GSSG
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + reduced glutathione
(5Z,13E)-(15S)-11alpha,15-dihydroxyprosta-5,13-dienoate + oxidized glutathione
i.e. prostaglandin H2
i.e. prostaglandin E2
?
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
1-chloro-2,4-dinitrobenzene + GSH
?
-
glutathione S-transferase activity
-
?
5-hydroperoxyeicosatetraenoic acid + 2 GSH
5-hydroxyeicosatetraenoic acid + GSSG + H2O
-
-
-
?
Prostaglandin G1
15-Hydroperoxy-prostaglandin E1
-
at 50% of the activity relative to prostaglandin H
major product
?
Prostaglandin H
?
-
involved in prostaglandin synthesis, which in the case of prostaglandin E is likely to be associated with the subversion or suppression of host immunity
-
-
?
(5Z,13E)-(15S)-9a,11a-epidioxy-15-hydroxyprosta-5,13-dienoate + GSH
(5Z,13E)-(15S)-11a,15-dihydroxyprosta-5,13-dienoate + GSSG
-
-
-
-
?
(5Z,13E)-(15S)-9a,11a-epidioxy-15-hydroxyprosta-5,13-dienoate + GSH
(5Z,13E)-(15S)-11a,15-dihydroxyprosta-5,13-dienoate + GSSG
-
i.e. prostaglandin H2
i.e. prostaglandin E2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
PGH2
PGE2
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + GSH
(5Z,13E)-(15S)-11alpha,15-dihydroxyprosta-5,13-dienoate + GSSG
-
i.e. prostaglandin H2
i.e. prostaglandin E2
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + GSH
(5Z,13E)-(15S)-11alpha,15-dihydroxyprosta-5,13-dienoate + GSSG
i.e. prostaglandin H2
i.e. prostaglandin E2
?
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
?
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
?
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
reaction of heme-free isozyme mPGES2
-
-
?
prostaglandin G2
15-hydroperoxy-prostaglandin E2
-
at 50% of the activity relative to prostaglandin H
major product
?
prostaglandin G2
15-hydroperoxy-prostaglandin E2
-
at pH 7.5, 2.5 mM glutathione and 10 microM substrate
-
-
?
Prostaglandin H1
Prostaglandin E1
-
i.e. 15-hydroxy-9alpha,11alpha-peroxidoprosta-13-enoic acid
-
?
Prostaglandin H2
Prostaglandin E2
-
i.e. 15-hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid
-
?
Prostaglandin H2
Prostaglandin E2
-
i.e. 15-hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid
-
?
Prostaglandin H2
Prostaglandin E2
-
-
660669, 662071, 667959, 668886, 670732, 702158, 702165, 702622, 703593, 706521, 714421, 714468, 715100, 715541, 715856, 715865, 747278, 748368, 748441, 748542, 748846
-
-
?
Prostaglandin H2
Prostaglandin E2
-
at pH 7.5, 2.5 mM glutathione and 10 microM substrate
-
-
?
Prostaglandin H2
Prostaglandin E2
-
mPGES-1 is a gonadotropin-regulated enzyme
-
-
?
Prostaglandin H2
Prostaglandin E2
mPGES-1 is a gonadotropin-regulated enzyme
-
-
?
Prostaglandin H2
Prostaglandin E2
-
-
662071, 667830, 702146, 702949, 703978, 705284, 706576, 713719, 714401, 714944, 716081, 716814, 746707, 747229, 748296
-
-
?
Prostaglandin H2
Prostaglandin E2
-
isozyme mPEGS-2 has an important role in urogenital function
-
-
?
Prostaglandin H2
Prostaglandin E2
-
i.e. 15-hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid
-
?
Prostaglandin H2
Prostaglandin E2
-
i.e. 15-hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid
-
?
Prostaglandin H2
Prostaglandin E2
-
i.e. 15-hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid
-
?
Prostaglandin H2
Prostaglandin E2
-
-
660669, 660677, 660973, 662071, 663277, 667165, 702165, 702949, 705284, 715541, 716814, 747229, 749371
-
-
?
Prostaglandin H2
Prostaglandin E2
-
i.e. 15-hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid
-
?
additional information
?
-
-
the enzyme also shows glutathione transferase activity with 1-chloro-2,4-dinitrobenzene
-
-
?
additional information
?
-
-
platelet-derived growth factor-induced increase in enzyme activity occurs within min after exposure to the growth factor
-
-
?
additional information
?
-
-
glutathione-heme-complex bound enzyme catalyzes formation of 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid and malonaldehyde from prostaglandin H2, i.e. shows lyase activity
-
-
?
additional information
?
-
heme-free isozyme mPGES2 and heme-bound isozyme mPGES2 catalyze isomerization of prostaglandin H2 to prostaglandin E2 and conversion of prostaglandin H2 to to (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoic acid and malondialdehyde, respectively
-
-
?
additional information
?
-
-
concordant induction of terminal prostaglandin E2 synthase with cyclooxygenase-2 leads to the preferred production of prostaglandin E2 over thromboxane B2 and prostaglandin D2, by lipopolysaccharide-stimulated macrophages
-
-
?
additional information
additional information
-
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate, PGH2, mutation R126A/Q creates a glutathione-dependent reductase which is able to convert prostaglandin H2 to prostaglandin F2alpha
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate, PGF2alpha
-
?
additional information
additional information
-
-
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate, PGH2, mutation R126A/Q creates a glutathione-dependent reductase which is able to convert prostaglandin H2 to prostaglandin F2alpha
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate, PGF2alpha
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
Prostaglandin H
?
-
involved in prostaglandin synthesis, which in the case of prostaglandin E is likely to be associated with the subversion or suppression of host immunity
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-