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Information on EC - heme oxygenase (biliverdin-producing)

for references in articles please use BRENDA:EC1.14.14.18
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IUBMB Comments
This mammalian enzyme participates in the degradation of heme. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules . The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. The enzyme requires NAD(P)H and EC, NADPH---hemoprotein reductase. cf. EC, heme oxygenase (biliverdin-producing, ferredoxin).
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The enzyme appears in viruses and cellular organisms
biliverdin-producing heme oxygenase, ChuS, ChuZ, haem oxygenase, heme oxygenase, heme oxygenase 1, heme oxygenase 2, heme oxygenase-1, heme oxygenase-2, HemO, more
protoheme + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O
show the reaction diagram