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Information on EC 1.14.14.18 - heme oxygenase (biliverdin-producing)

for references in articles please use BRENDA:EC1.14.14.18
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IUBMB Comments
This mammalian enzyme participates in the degradation of heme. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules . The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. The enzyme requires NAD(P)H and EC 1.6.2.4, NADPH---hemoprotein reductase. cf. EC 1.14.15.20, heme oxygenase (biliverdin-producing, ferredoxin).
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
heme oxygenase-1, heme oxygenase, heme oxygenase 1, hmox1, haem oxygenase, hsp32, heme oxygenase-2, hmox2, heme oxygenase 2, hmox1a, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
protoheme + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O
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