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calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
reconstitution of the enzyme system in E. coli cells, consisting of NADH-adrenodoxin reductase, adrenodoxin and CYP27B1
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
reconstitution of the enzyme system in E. coli cells, consisting of NADH-adrenodoxin reductase, adrenodoxin and CYP27B1
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
25-hydroxyvitamin D3 1alpha-hydroxylase is a cytochrome P-450-dependent mixed-function oxidase
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
25-hydroxyvitamin D3 1alpha-hydroxylase is a cytochrome P-450-dependent mixed-function oxidase
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
25-hydroxyvitamin D3 1alpha-hydroxylase is a cytochrome P-450-dependent mixed-function oxidase
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
25-hydroxyvitamin D3 1alpha-hydroxylase is a cytochrome P-450-dependent mixed-function oxidase
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
amino acid composition and terminal sequence determination
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
cytochrome P-450 enzyme
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
cytochrome P-450 enzyme
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
cytochrome P-450 enzyme
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
amino acid sequence determination
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
kidney mitochondrial 25-hydroxyvitamin D3-1alpha-hydroxylation system consists of a renal ferredoxin reductase (flavoprotein), renal ferredoxin and cytochrome P-450
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
reconstituted with cytochrome P-450, adrenal ferredoxin, i.e. adrenodoxin, and adrenodoxin reductase
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
reconstituted with cytochrome P-450, adrenal ferredoxin, i.e. adrenodoxin, and adrenodoxin reductase
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
reconstituted with cytochrome P-450, adrenal ferredoxin, i.e. adrenodoxin, and adrenodoxin reductase
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
reconstituted with cytochrome P-450, adrenal ferredoxin, i.e. adrenodoxin, and adrenodoxin reductase
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
reconstituted with cytochrome P-450, adrenal ferredoxin, i.e. adrenodoxin, and adrenodoxin reductase
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
reconstituted with cytochrome P-450, adrenal ferredoxin, i.e. adrenodoxin, and adrenodoxin reductase
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
cytochrome P-450 type is specific for hydroxylation site of 25-hydroxyvitamin D3
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
enzyme can be reconstituted with the 3 components: cytochrome P-450D1alpha, NADPH-renodoxin reductase and renodoxin
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
ferredoxin, ferredoxin reductase and cytochrome P-450
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
ferredoxin, ferredoxin reductase and cytochrome P-450
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
ferredoxin, ferredoxin reductase and cytochrome P-450
-
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O
-
-
-
-
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(24R),25-dihydroxycholecalciferol + NADPH + O2
1alpha,24,25-trihydroxycholecalciferol + NADP+ + H2O
(24R),25-dihydroxyvitamin D3 + NADPH + O2
1alpha,24,25-trihydroxyvitamin D3 + NADP+ + H2O
-
-
-
-
?
1alpha-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
-
-
-
?
20-hydroxyvitamin D3 + NADPH + O2
1alpha,20-dihydroxyvitamin D3 + NADP+ + H2O
-
-
-
-
?
23,25-dihydroxycholecalciferol + NADPH + O2
?
24,25-dihydroxycholecalciferol + reduced adrenodoxin + O2
1alpha,24,25-trihydroxycholecalciferol + oxidized adrenodoxin + H2O
-
-
-
-
r
24-oxo-23,25-dihydroxycholecalciferol + NADPH + O2
?
24-oxo-25-hydroxycholecalciferol + NADPH + O2
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
25-hydroxyvitamin D2 + NADPH + H+ + O2
1,25-dihydroxyvitamin D2 + NADP+ + H2O
-
-
-
-
?
25-hydroxyvitamin D3 + H+ + O2
25-hydroxyvitamin D3 + H2O
-
-
-
?
25-hydroxyvitamin D3 + NADPH + H+ + O2
1,25-dihydroxyvitamin D3 + NADP+ + H2O
-
-
-
-
?
25-hydroxyvitamin D3 + NADPH + O2
1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
cholecalciferol + NADPH + O2
25-hydroxyvitamin D3 + NADP+ + H2O
-
-
-
-
?
additional information
?
-
(24R),25-dihydroxycholecalciferol + NADPH + O2
1alpha,24,25-trihydroxycholecalciferol + NADP+ + H2O
-
-
-
?
(24R),25-dihydroxycholecalciferol + NADPH + O2
1alpha,24,25-trihydroxycholecalciferol + NADP+ + H2O
-
higher activity than with 25-hydroxycholecalciferol
-
-
?
(24R),25-dihydroxycholecalciferol + NADPH + O2
1alpha,24,25-trihydroxycholecalciferol + NADP+ + H2O
-
higher activity than with 25-hydroxycholecalciferol
-
?
(24R),25-dihydroxycholecalciferol + NADPH + O2
1alpha,24,25-trihydroxycholecalciferol + NADP+ + H2O
-
reconstituted system
-
-
?
(24R),25-dihydroxycholecalciferol + NADPH + O2
1alpha,24,25-trihydroxycholecalciferol + NADP+ + H2O
-
-
-
?
(24R),25-dihydroxycholecalciferol + NADPH + O2
1alpha,24,25-trihydroxycholecalciferol + NADP+ + H2O
-
recombinant enzyme
-
-
?
(24R),25-dihydroxycholecalciferol + NADPH + O2
1alpha,24,25-trihydroxycholecalciferol + NADP+ + H2O
-
higher activity than with 25-hydroxycholecalciferol
-
-
?
(24R),25-dihydroxycholecalciferol + NADPH + O2
1alpha,24,25-trihydroxycholecalciferol + NADP+ + H2O
-
higher activity than with 25-hydroxycholecalciferol
-
?
23,25-dihydroxycholecalciferol + NADPH + O2
?
-
low activity
-
-
?
23,25-dihydroxycholecalciferol + NADPH + O2
?
-
recombinant enzyme
-
-
?
24-oxo-23,25-dihydroxycholecalciferol + NADPH + O2
?
-
low activity
-
-
?
24-oxo-23,25-dihydroxycholecalciferol + NADPH + O2
?
-
recombinant enzyme
-
-
?
24-oxo-25-hydroxycholecalciferol + NADPH + O2
?
-
low activity, reconstituted system
-
-
?
24-oxo-25-hydroxycholecalciferol + NADPH + O2
?
-
recombinant enzyme
-
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
energy-dependent transhydrogenation is of importance
-
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
-
-
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
central role in calcium regulation
-
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
-
-
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
-
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
recombinant in E. coli
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
enzyme activity is correlated with phosphate content in serum
-
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
central role in calcium regulation
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
central role in calcium regulation
-
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
recombinant in E. coli
-
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
recombinant in E. coli
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
central role in calcium regulation
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
-
-
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
central role in calcium regulation
-
-
?
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
-
-
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
-
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
-
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
1,25(OH)2D3 is an antiproliferative agent that may inhibit proliferation of breast cancer cells
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
1,25-dihydroxyvitamin D3 (1,25-D3) is a key determinant of calcium homeostasis, cell proliferation and differentiation, calcium and vitamin D might have a protective function against colorectal tumor pathogenesis, overview
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
bioactivation
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
extra-renal functions of 1alpha-hydroxylase in vitamin D physiology, regulation, overview
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
regulation of enzyme expression in kidney proximal tubules, overview
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
substrate activation by the rate-limiting enzyme 1alpha-hydroxylase in cells of the immune system under control of immune stimuli, such as interferon-gamma, in pathological situations, such as sarcoidosis, this can lead to systemic excess of 1,25(OH)2D3 and hypercalcemia
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
the enzyme hydroxylates the major circulating form of vitamin D to the active systemic hormone 1,25(OH)2D3, local production of 1,25(OH)2D3 appears to occur also at other sites where 1alpha-hydroxylase is expressed for autocrine/paracrine regulation, overview
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
the enzyme is involved in the vitamin D signaling pathway in colonic epithelial cell differentiation by butyrate, mechanism, overview
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
the enzyme is responsible for final hydroxylation of vitamin D3, in response to IFNgamma and CD14/TLR4 activation
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
-
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
deficiency of the enzyme, due to mutation of residues Q65 and T409, in substrate binding causes vitamin D-dependent rickets type 1, overview
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
binding of 25-hydroxyvitamin D3 in a structural pocket involving residues Q65, S408, and T409, molecular modeling and substrate docking
-
-
?
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
-
-
-
?
25-hydroxyvitamin D3 + NADPH + O2
1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
-
-
-
?
25-hydroxyvitamin D3 + NADPH + O2
1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
final step of the activation of vitamin D
-
-
?
25-hydroxyvitamin D3 + NADPH + O2
1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
final step of the activation of vitamin D, involved in tumor suppressing activity due to the tumor growth inhibiting effect of 1alpha,25-dihydroxyvitamin D3
-
-
?
25-hydroxyvitamin D3 + NADPH + O2
1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
-
-
-
?
25-hydroxyvitamin D3 + NADPH + O2
1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
final step of the activation of vitamin D
-
-
?
25-hydroxyvitamin D3 + NADPH + O2
1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
-
-
-
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
recombinant enzyme
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
enzyme shows vitamin D3 25- and 1alpha-hydroxylase activity
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
-
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
calcidiol + NADPH + O2
calcitriol + NADP+ + H2O
highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol
calcitriol is identical with 1,25-dihydroxycholecalciferol
?
additional information
?
-
-
not: cholecalciferol, dihydrotachysterol
-
-
?
additional information
?
-
-
the 25-hydroxy group is essential for 1alpha-hydroxylating activity, the 24-hydroxy group enhances the activity, the 23-hydroxy group strongly reduces activity
-
-
?
additional information
?
-
-
not active with (23S),25-dihydroxycholecalciferol and 24-oxo-23,25-dihydroxycholecalciferol
-
-
?
additional information
?
-
-
25(OH)D3 therapy is useful for colorectal cancer chemoprevention but provitamin D is less likely to be useful for colorectal cancer chemotherapy, overview
-
-
?
additional information
?
-
-
both butyrate and 1alpha-25(OH)2D3 stimulate differentiation of Caco-2 cells, while 25(OH)2D3 has no impact on cell differentiation
-
-
?
additional information
?
-
-
colonic and renal vitamin D hydroxylases are regulated independently
-
-
?
additional information
?
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functional analysis of vitamin D metabolism in cancer, locally synthesized 1,25(OH)2D3 may be inefficient in preventing tumor progression, mechanism, overview
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immune regulation of the enzyme in monocytes, cross-talk between the JAK-STAT, the NFkappaB, and the p38 MAPK pathways is necessary, and direct binding of C/EBPbeta to its recognition sites in the promoter of the 1alpha-hydroxylase gene is a prerequisite, overview
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the enzyme is involved in local production of 1alpha,25-dihydroxyvitamin D, i.e. 1alpha,25(OH)2D3, in tumorigenesis
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the 1alpha-OHase gene is a tumor suppressor gene responsible for the normal regulation of prostate cell growth
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the 25-hydroxy group is essential for 1alpha-hydroxylating activity, the 24-hydroxy group enhances the activity, the 23-hydroxy group strongly reduces activity
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the 25-hydroxy group is essential for 1alpha-hydroxylating activity, the 24-hydroxy group enhances the activity, the 23-hydroxy group strongly reduces activity
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no activity with 24,25,26,27-tetranor-23-hydroxyvitamin D3 and vitamin D3
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PTH and PTHrP are involved in enzyme regulation, PTH is the major protein hormone regulating calcium homeostasis, PTHrP is a PTH-like factor responsible for humoral hypercalcemia of malignancy, both peptides are required to achieve normal fetal skeletal morphogenesis, overview
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1alpha,25(OH)2-19-nor-D3 is not converted to 1alpha,25(OH)2-19-nor-D3 by CYP27B1
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25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 in vesicles undergo 1alpha-hydroxylation with similar kinetics. CYP27B1 also catalyzes 1alpha-hydroxylation of vesicle-associated 24R,25-dihydroxyvitamin D3 and 20-hydroxyvitamin D3, and 25-hydroxylation of 1alpha-hydroxyvitamin D3 and 1alpha-hydroxyvitamin D2, but with much lower efficiency than for 25(OH)D3, reactions in reconstituted phospholipid vesicles with the substrates associating to the membrane, effect of vesicle phospholipid composition on metabolism of 25(OH)D3 by CYP27B1, overview
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a multifunctional enzyme catalyzing also the reaction of cholestanetriol 26-monooxygenase, EC 1.14.13.15, as well as oxidation of 5beta-cholestane-3alpha,7alpha,12alpha,27-tetraol into the corresponding C27-acid, and the 24- and 25-hydroxylation of cholesterol, the truncated enzyme form is less efficient than the full-length CYP27A in the 27-hydroxylation of C27-sterols, and much less efficient in the 25-hydroxylation of 1alpha-hydroxyvitamin D3
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Vdh, a cytochrome P450 enzyme, is responsible for the biocatalytic conversion of vitamin D3, catalyzing the two-step hydroxylation of VD3, i.e. the conversion of VD3 to 25-hydroxyvitamin D3 (25(OH)VD3) and then of 25(OH)VD3 to 1alpha,25(OH)2VD3, a hormonal form of VD3. Anti-parallel substrate binding modes enable sequential hydroxylation, structure-function analysis, overview
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1.14.15.18 calcidiol 1-monooxygenase
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