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EC 4.1.2.6
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formerly
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glycine hydroxymethyltransferrase
L-serine hydroxymethyltransferase
mitochondrial serine hydroxymethyltransferase
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serine hydroxymethyl transferase
serine hydroxymethylase hydroxymethyltransferase, serine
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serine hydroxymethyltransferase
serine hydroxymethyltransferase 1
serine hydroxymethyltransferase 2
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serine hydroxymethyltransferase 2alpha
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serine transhydroxymethylase
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serine:H4F hydroxymethyltransferase
serine:tetrahydrofolate hydroxymethyltransferase
zebrafish cytosolic serine hydroxymethyltransferase
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zebrafish mitochondiral serine hydroxymethyltransferase
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GlyA
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GlyA protein
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glycine hydroxymethyltransferrase
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glycine hydroxymethyltransferrase
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L-serine hydroxymethyltransferase
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L-serine hydroxymethyltransferase
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L-serine hydroxymethyltransferase
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MJ1597
locus name
serine hydroxymethyl transferase
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serine hydroxymethyl transferase
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serine hydroxymethyl transferase
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serine hydroxymethyl transferase
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serine hydroxymethyl transferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase
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serine hydroxymethyltransferase 1
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serine hydroxymethyltransferase 1
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serine hydroxymethyltransferase 1
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serine:H4F hydroxymethyltransferase
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serine:H4F hydroxymethyltransferase
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serine:tetrahydrofolate hydroxymethyltransferase
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serine:tetrahydrofolate hydroxymethyltransferase
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SHM1
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SHM2
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SHMT
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SHMT-1
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SHMT-L
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SHMT-S
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SHMT1
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SHMT2
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SHMT2alpha
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
stereochemistry
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
stereochemistry
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
stereochemistry
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
stereochemistry
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
stereochemistry
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
stereochemistry
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
evidence for a direct transfer mechanism for the enzyme catalysed reaction
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
general mechanism of pyridoxal 5'-phosphate-catalyzed aldolic cleavage, racemisation, and transamination reactions, and catalytic mechanism of the transaldimination reaction involving Tyr55, His228, and Arg235, overview. Tyr55 is contributed by the symmetry-related monomer, with respect to the pyridoxal 5'-phosphate-binding subunit, and functions as the general acid-base catalyst in this proton transfer
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
general mechanism of pyridoxal 5'-phosphate-catalyzed aldolic cleavage, racemisation, and transamination reactions, and catalytic mechanism of the transaldimination reaction involving Tyr55, His228, and Arg235, overview. Tyr55 is contributed by the symmetry-related monomer, with respect to the pyridoxal 5'-phosphate-binding subunit, and functions as the general acid-base catalyst in this proton transfer
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
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5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
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(6S)-tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
5,10-methenyl-tetrahydropteroyl pentaglutamate + glycine + H2O
5-formyl-tetrahydropteroyl pentaglutamate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-Ser
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the enzyme is a major source of one-carbon units for cellular metabolism. Potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake
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r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
5,6,7,8-tetrahydrofolate + L-Ser
5,10-methylenetetrahydrofolate + glycine + H2O
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r
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
D-alanine + (benzyloxy)acetaldehyde + H2O
(3R)-4-(benzyloxy)-3-hydroxy-L-isovaline + (3S)-4-(benzyloxy)-3-hydroxy-L-isovaline
D-alanine + 2-fluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-methylpropanoic acid
D-alanine + 3-phenylpropanal + H2O
(3S)-3-hydroxy-2-methyl-5-phenyl-L-norvaline + (3R)-3-hydroxy-2-methyl-5-phenyl-L-norvaline
D-alanine + 4-(benzyloxy)butanal + H2O
(3R)-3-hydroxy-4-(3-phenylpropoxy)-L-isovaline + (3S)-3-hydroxy-4-(3-phenylpropoxy)-L-isovaline
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?
D-alanine + 4-chlorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-methylpropanoic acid + (2S,3R)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-methylpropanoic acid
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?
D-alanine + 4-formylphenyl acetate + H2O
(2S,3S)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-methylpropanoic acid + (2S,3R)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-methylpropanoic acid
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?
D-alanine + 4-hydroxybenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropanoic acid
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?
D-alanine + 4-nitrobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-methyl-3-(4-nitrophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-methyl-3-(4-nitrophenyl)propanoic acid
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?
D-alanine + benzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-methyl-3-phenylpropanoic acid + (2S,3R)-2-amino-3-hydroxy-2-methyl-3-phenylpropanoic acid
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?
D-alanine + benzyl (2-oxoethyl)carbamate + H2O
(3S)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-L-isovaline + (3R)-4-[[(benzyloxy)carbonyl]amino]-3-hydroxy-L-isovaline
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?
D-alanine + benzyl (3-oxopropyl)carbamate + H2O
(3S)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-methyl-L-lysine + (2S,3R)-2-amino-6-[[(benzyloxy)carbonyl]amino]-3-hydroxy-2-methylhexanoic acid
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?
D-alanine + benzyl [(2R)-1-oxopropan-2-yl]carbamate + H2O
(3S)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-methyl-L-lysine + (3R)-N6-[(benzyloxy)carbonyl]-3-hydroxy-2-methyl-L-lysine
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?
D-alanine + benzyl [(2S)-1-oxopropan-2-yl]carbamate + H2O
(3S,4S)-4-([(benzyloxy)carbonyl]amino)-3-hydroxy-2-methyl-L-norvaline + (3R,4S)-4-([(benzyloxy)carbonyl]amino)-3-hydroxy-2-methyl-L-norvaline
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?
D-alanine + pentafluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-methyl-3-(pentafluorophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-methyl-3-(pentafluorophenyl)propanoic acid
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?
D-alanine + phenoxyacetaldehyde + H2O
(3R)-3-hydroxy-4-phenoxy-L-isovaline + (3S)-3-hydroxy-4-phenoxy-L-isovaline
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?
D-alanine + phenylacetaldehyde + H2O
(3S)-3-hydroxy-4-phenyl-L-isovaline + (3R)-3-hydroxy-4-phenyl-L-isovaline
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?
D-serine + (benzyloxy)acetaldehyde + H2O
(3R)-4-(benzyloxy)-2',3-dihydroxy-L-isovaline + (3S)-4-(benzyloxy)-2',3-dihydroxy-L-isovaline
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?
D-serine + 2-fluorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid + (2S,3R)-2-amino-3-(2-fluorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid
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?
D-serine + 3-phenylpropanal + H2O
(3S)-3-hydroxy-2-(hydroxymethyl)-5-phenyl-L-norvaline + (3R)-3-hydroxy-2-(hydroxymethyl)-5-phenyl-L-norvaline
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?
D-serine + 4-(benzyloxy)butanal + H2O
(3S)-4-[[(benzyloxy)carbonyl]amino]-2',3-dihydroxy-L-isovaline + (3S)-2',3-dihydroxy-4-(3-phenylpropoxy)-L-isovaline
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?
D-serine + 4-chlorobenzaldehyde + H2O
(2S,3S)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid + (2S,3R)-2-amino-3-(4-chlorophenyl)-3-hydroxy-2-(hydroxymethyl)propanoic acid
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?
D-serine + 4-formylphenyl acetate + H2O
(2S,3S)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-(hydroxymethyl)propanoic acid + (2S,3R)-3-[4-(acetyloxy)phenyl]-2-amino-3-hydroxy-2-(hydroxymethyl)propanoic acid
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?
D-serine + 4-hydroxybenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic acid
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?
D-serine + 4-nitrobenzaldehyde + H2O
(2S,3S)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-nitrophenyl)propanoic acid + (2S,3R)-2-amino-3-hydroxy-2-(hydroxymethyl)-3-(4-nitrophenyl)propanoic acid
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2.1.2.1 glycine hydroxymethyltransferase
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