Literature summary for 2.1.2.1 extracted from

Kandoth, P.K.; Liu, S.; Prenger, E.; Ludwig, A.; Lakhssassi, N.; Heinz, R.; Zhou, Z.; Howland, A.; Gunther, J.; Eidson, S.; Dhroso, A.; LaFayette, P.; Tucker, D.; Johnson, S.; Anderson, J.; Alaswad, A.; Cianzio, S.R.; Parrott, W.A.; Korkin, D.; Meksem, K.; Mitchum, M.G.
Systematic mutagenesis of serine hydroxymethyltransferase reveals an essential role in nematode resistance (2017), Plant Physiol., 175, 1370-1380 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli GS245(DE3)pLysS cells	Glycine max

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5,10-methylenetetrahydrofolate + glycine + H2O	Glycine max	-	tetrahydrofolate + L-serine	-	r
tetrahydrofolate + L-serine	Glycine max	-	5,10-methylenetetrahydrofolate + glycine + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Glycine max	-	cultivar Williams 82	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + glycine + H2O	-	Glycine max	tetrahydrofolate + L-serine	-	r
tetrahydrofolate + L-serine	-	Glycine max	5,10-methylenetetrahydrofolate + glycine + H2O	-	r

Synonyms

Synonyms	Comment	Organism
Rhg4	-	Glycine max
serine hydroxymethyltransferase	-	Glycine max
SHMT08	-	Glycine max

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Glycine max

General Information

General Information	Comment	Organism
physiological function	the enzyme has additional functions aside from its main enzymatic role in soybean cyst nematode resistance	Glycine max

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Release 2023.1 (January 2023)