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Literature summary for 2.1.2.1 extracted from

  • Agrawal, S.; Kumar, A.; Srivastava, V.; Mishra, B.N.
    Cloning, expression, activity and folding studies of serine hydroxymethyltransferase: a target enzyme for cancer chemotherapy (2003), J. Mol. Microbiol. Biotechnol., 6, 67-75.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme is a target for antibiotics Escherichia coli
medicine the cytosolic SHMT is a target enzyme for chemotherapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme plays an indispensable role in nucleic acid biosynthesis ?
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ser + tetrahydrofolate
-
Escherichia coli Gly + 5,10-methylenetetrahydrofolate
-
r
L-Ser + tetrahydrofolate
-
Homo sapiens Gly + 5,10-methylenetetrahydrofolate
-
r
additional information the enzyme plays an indispensable role in nucleic acid biosynthesis Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
eSHMT
-
Escherichia coli
hSHMT
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Escherichia coli
pyridoxal 5'-phosphate
-
Homo sapiens