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Literature summary for 2.1.2.1 extracted from

  • Talwar, R.; Appaji Rao, N.; Savithri, H.S.
    A change in reaction specificity of sheep liver serine hydroxymethyltransferase: induction of NADH oxidation upon mutation of His230 to Tyr (2000), Eur. J. Biochem., 267, 929-934.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Ovis aries

Protein Variants

Protein Variants Comment Organism
H230Y 90% loss of enzyme activity, confers ability to oxidize NADH Ovis aries

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Ovis aries
0.52
-
mutant enzyme Ovis aries
4.8
-
-
Ovis aries

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + tetrahydrofolate
-
Ovis aries glycine + 5,10-methylenetetrahydrofolate + H2O
-
?
additional information enzyme catalyzes the pyridoxal 5'-phosphate dependent reversible cleavage of 3-hydroxy-alpha-amino acids Ovis aries ?
-
?
additional information mutant enzyme H230Y catalyses oxidation of NADH, not wild type enzyme, H230A, H230F, H230N Ovis aries ?
-
?
additional information enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate Ovis aries ?
-
?
additional information enzyme catalyses the racemization of D- and L-alanine Ovis aries ?
-
?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Ovis aries