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Literature summary for 2.1.2.1 extracted from

  • Fu, T.F.; Scarsdale, J.N.; Kazanina, G.; Schirch, V.; Wright, H.T.
    Location of the pteroylpolyglutamate-binding site on rabbit cytosolic serine hydroxymethyltransferase (2003), J. Biol. Chem., 278, 2645-2653.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure at 2.7 A resolution of the recombinant enzyme with active-site bound 5-formyl-tetrahydropteroylglutamate is obtained by soaking unliganded crystals of of the recombinant enzyme in 5-formyl-tetrahydropteroylglutamate, the conformation of the pteridine ring and its interactions with the enzyme differ slightly from those observed in complexes of the monoglutamate cofactor Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Oryctolagus cuniculus 5829
-

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + glycine + H2O
-
Oryctolagus cuniculus tetrahydrofolate + L-serine
-
r

Synonyms

Synonyms Comment Organism
SHMT
-
Oryctolagus cuniculus