BRENDA - Enzyme Database
show all sequences of 2.1.2.1

Serine hydroxymethyltransferase

Schirch, L.; Adv. Enzymol. Relat. Areas Mol. Biol. 53, 83-112 (1982) View publication on PubMed

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
D-alanine
-
Bos taurus
D-alanine
-
Cricetulus griseus
D-alanine
-
Oryctolagus cuniculus
D-alanine
-
Ovis aries
D-beta-fluoroalanine
-
Bos taurus
D-beta-fluoroalanine
-
Cricetulus griseus
D-beta-fluoroalanine
-
Oryctolagus cuniculus
D-beta-fluoroalanine
-
Ovis aries
D-cycloserine
-
Bos taurus
D-cycloserine
-
Cricetulus griseus
D-cycloserine
-
Oryctolagus cuniculus
D-cycloserine
-
Ovis aries
L-methionine
-
Saccharomyces cerevisiae
methyl methanethiosulfonate
-
Bos taurus
methyl methanethiosulfonate
-
Cricetulus griseus
methyl methanethiosulfonate
-
Oryctolagus cuniculus
methyl methanethiosulfonate
-
Ovis aries
S-adenosyl-L-methionine
-
Saccharomyces cerevisiae
tetrahydrofolate derivatives
-
Bos taurus
tetrahydrofolate derivatives
-
Cricetulus griseus
tetrahydrofolate derivatives
-
Oryctolagus cuniculus
tetrahydrofolate derivatives
-
Ovis aries
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Saccharomyces cerevisiae
additional information
-
additional information
pH-dependence of kinetic parameters
Cricetulus griseus
additional information
-
additional information
pH-dependence of kinetic parameters
Bos taurus
additional information
-
additional information
pH-dependence of kinetic parameters
Oryctolagus cuniculus
additional information
-
additional information
pH-dependence of kinetic parameters
Ovis aries
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Salmonella enterica subsp. enterica serovar Typhimurium
5737
-
cytoplasm
-
Cricetulus griseus
5737
-
cytoplasm
-
Saccharomyces cerevisiae
5737
-
cytoplasm
-
Bos taurus
5737
-
cytoplasm
-
Oryctolagus cuniculus
5737
-
cytoplasm
-
Neurospora crassa
5737
-
cytoplasm
-
Ovis aries
5737
-
mitochondrion
-
Saccharomyces cerevisiae
5739
-
mitochondrion
matrix
Cricetulus griseus
5739
-
mitochondrion
matrix
Bos taurus
5739
-
mitochondrion
matrix
Oryctolagus cuniculus
5739
-
mitochondrion
matrix
Ovis aries
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-serine + tetrahydrofolate
Saccharomyces cerevisiae
-
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Saccharomyces cerevisiae
?
L-serine + tetrahydrofolate
Salmonella enterica subsp. enterica serovar Typhimurium
may play important role in central nervous system
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium
?
L-serine + tetrahydrofolate
Cricetulus griseus
may play important role in central nervous system
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Cricetulus griseus
?
L-serine + tetrahydrofolate
Bos taurus
may play important role in central nervous system
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Bos taurus
?
L-serine + tetrahydrofolate
Oryctolagus cuniculus
may play important role in central nervous system
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Oryctolagus cuniculus
?
L-serine + tetrahydrofolate
Neurospora crassa
may play important role in central nervous system
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Neurospora crassa
?
L-serine + tetrahydrofolate
Ovis aries
may play important role in central nervous system
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Ovis aries
?
Organism
Organism
UniProt
Commentary
Textmining
Bos taurus
-
-
-
Cricetulus griseus
-
-
-
Neurospora crassa
-
-
-
Oryctolagus cuniculus
-
-
-
Ovis aries
-
-
-
Saccharomyces cerevisiae
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
Reaction
Reaction
Commentary
Organism
Reaction ID
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
Salmonella enterica subsp. enterica serovar Typhimurium
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
Cricetulus griseus
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
Bos taurus
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
Oryctolagus cuniculus
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
Neurospora crassa
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
mechanism
Ovis aries
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
stereochemistry
Salmonella enterica subsp. enterica serovar Typhimurium
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
stereochemistry
Cricetulus griseus
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
stereochemistry
Bos taurus
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
stereochemistry
Oryctolagus cuniculus
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
stereochemistry
Neurospora crassa
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
stereochemistry
Ovis aries
Source Tissue
Source Tissue
Commentary
Organism
Textmining
ovary
-
Cricetulus griseus
-
Storage Stability
Storage Stability
Organism
frozen, several months at pH 7.3
Oryctolagus cuniculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
alpha-methylserine + tetrahydrofolate
-
441420
Salmonella enterica subsp. enterica serovar Typhimurium
D-alanine + 5,10-methylenetetrahydrofolate
-
441420
Salmonella enterica subsp. enterica serovar Typhimurium
?
alpha-methylserine + tetrahydrofolate
-
441420
Cricetulus griseus
D-alanine + 5,10-methylenetetrahydrofolate
-
441420
Cricetulus griseus
?
alpha-methylserine + tetrahydrofolate
-
441420
Saccharomyces cerevisiae
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
alpha-methylserine + tetrahydrofolate
-
441420
Bos taurus
D-alanine + 5,10-methylenetetrahydrofolate
-
441420
Bos taurus
?
alpha-methylserine + tetrahydrofolate
-
441420
Oryctolagus cuniculus
D-alanine + 5,10-methylenetetrahydrofolate
-
441420
Oryctolagus cuniculus
?
alpha-methylserine + tetrahydrofolate
-
441420
Neurospora crassa
D-alanine + 5,10-methylenetetrahydrofolate
-
441420
Neurospora crassa
?
alpha-methylserine + tetrahydrofolate
-
441420
Ovis aries
D-alanine + 5,10-methylenetetrahydrofolate
-
441420
Ovis aries
?
L-serine + tetrahydrofolate
-
441420
Salmonella enterica subsp. enterica serovar Typhimurium
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Salmonella enterica subsp. enterica serovar Typhimurium
?
L-serine + tetrahydrofolate
-
441420
Cricetulus griseus
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Cricetulus griseus
?
L-serine + tetrahydrofolate
-
441420
Saccharomyces cerevisiae
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Saccharomyces cerevisiae
?
L-serine + tetrahydrofolate
-
441420
Bos taurus
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Bos taurus
?
L-serine + tetrahydrofolate
-
441420
Oryctolagus cuniculus
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Oryctolagus cuniculus
r
L-serine + tetrahydrofolate
-
441420
Neurospora crassa
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Neurospora crassa
?
L-serine + tetrahydrofolate
-
441420
Ovis aries
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Ovis aries
r
L-serine + tetrahydrofolate
may play important role in central nervous system
441420
Salmonella enterica subsp. enterica serovar Typhimurium
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Salmonella enterica subsp. enterica serovar Typhimurium
?
L-serine + tetrahydrofolate
may play important role in central nervous system
441420
Cricetulus griseus
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Cricetulus griseus
?
L-serine + tetrahydrofolate
may play important role in central nervous system
441420
Bos taurus
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Bos taurus
?
L-serine + tetrahydrofolate
may play important role in central nervous system
441420
Oryctolagus cuniculus
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Oryctolagus cuniculus
?
L-serine + tetrahydrofolate
may play important role in central nervous system
441420
Neurospora crassa
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Neurospora crassa
?
L-serine + tetrahydrofolate
may play important role in central nervous system
441420
Ovis aries
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Ovis aries
?
additional information
-
441420
Saccharomyces cerevisiae
?
-
-
-
?
additional information
no: L-threonine
441420
Salmonella enterica subsp. enterica serovar Typhimurium
?
-
-
-
?
additional information
no: L-threonine
441420
Cricetulus griseus
?
-
-
-
?
additional information
no: L-threonine
441420
Bos taurus
?
-
-
-
?
additional information
no: L-threonine
441420
Oryctolagus cuniculus
?
-
-
-
?
additional information
no: L-threonine
441420
Neurospora crassa
?
-
-
-
?
additional information
no: L-threonine
441420
Ovis aries
?
-
-
-
?
additional information
no: D-serine
441420
Cricetulus griseus
?
-
-
-
?
additional information
no: D-serine
441420
Bos taurus
?
-
-
-
?
additional information
no: D-serine
441420
Oryctolagus cuniculus
?
-
-
-
?
additional information
no: D-serine
441420
Ovis aries
?
-
-
-
?
additional information
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
441420
Salmonella enterica subsp. enterica serovar Typhimurium
?
-
-
-
?
additional information
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
441420
Cricetulus griseus
?
-
-
-
?
additional information
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
441420
Bos taurus
?
-
-
-
?
additional information
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
441420
Oryctolagus cuniculus
?
-
-
-
?
additional information
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
441420
Neurospora crassa
?
-
-
-
?
additional information
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
441420
Ovis aries
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
homotetramer
-
Cricetulus griseus
homotetramer
-
Saccharomyces cerevisiae
homotetramer
-
Bos taurus
homotetramer
-
Oryctolagus cuniculus
homotetramer
-
Ovis aries
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
30
-
several h, pH 5.8-8.5, cytosol
Oryctolagus cuniculus
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
5.8
8.5
stable, rabbit cytosol
Oryctolagus cuniculus
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Saccharomyces cerevisiae
pyridoxal 5'-phosphate
requirement, 4 mol per mol enzyme
Cricetulus griseus
pyridoxal 5'-phosphate
requirement, 4 mol per mol enzyme
Bos taurus
pyridoxal 5'-phosphate
requirement, 4 mol per mol enzyme
Oryctolagus cuniculus
pyridoxal 5'-phosphate
requirement, 4 mol per mol enzyme
Ovis aries
pyridoxal 5'-phosphate
mechanism, active-site structure
Cricetulus griseus
pyridoxal 5'-phosphate
mechanism, active-site structure
Bos taurus
pyridoxal 5'-phosphate
mechanism, active-site structure
Oryctolagus cuniculus
pyridoxal 5'-phosphate
mechanism, active-site structure
Ovis aries
tetrahydrofolate
requirement with L-serine or L-2-methylserine as substrate
Cricetulus griseus
tetrahydrofolate
requirement with L-serine or L-2-methylserine as substrate
Saccharomyces cerevisiae
tetrahydrofolate
requirement with L-serine or L-2-methylserine as substrate
Bos taurus
tetrahydrofolate
requirement with L-serine or L-2-methylserine as substrate
Oryctolagus cuniculus
tetrahydrofolate
requirement with L-serine or L-2-methylserine as substrate
Ovis aries
tetrahydrofolate
mechanism
Cricetulus griseus
tetrahydrofolate
mechanism
Bos taurus
tetrahydrofolate
mechanism
Oryctolagus cuniculus
tetrahydrofolate
mechanism
Ovis aries
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Saccharomyces cerevisiae
pyridoxal 5'-phosphate
requirement, 4 mol per mol enzyme
Cricetulus griseus
pyridoxal 5'-phosphate
requirement, 4 mol per mol enzyme
Bos taurus
pyridoxal 5'-phosphate
requirement, 4 mol per mol enzyme
Oryctolagus cuniculus
pyridoxal 5'-phosphate
requirement, 4 mol per mol enzyme
Ovis aries
pyridoxal 5'-phosphate
mechanism, active-site structure
Cricetulus griseus
pyridoxal 5'-phosphate
mechanism, active-site structure
Bos taurus
pyridoxal 5'-phosphate
mechanism, active-site structure
Oryctolagus cuniculus
pyridoxal 5'-phosphate
mechanism, active-site structure
Ovis aries
tetrahydrofolate
requirement with L-serine or L-2-methylserine as substrate
Cricetulus griseus
tetrahydrofolate
requirement with L-serine or L-2-methylserine as substrate
Saccharomyces cerevisiae
tetrahydrofolate
requirement with L-serine or L-2-methylserine as substrate
Bos taurus
tetrahydrofolate
requirement with L-serine or L-2-methylserine as substrate
Oryctolagus cuniculus
tetrahydrofolate
requirement with L-serine or L-2-methylserine as substrate
Ovis aries
tetrahydrofolate
mechanism
Cricetulus griseus
tetrahydrofolate
mechanism
Bos taurus
tetrahydrofolate
mechanism
Oryctolagus cuniculus
tetrahydrofolate
mechanism
Ovis aries
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
D-alanine
-
Cricetulus griseus
D-alanine
-
Bos taurus
D-alanine
-
Oryctolagus cuniculus
D-alanine
-
Ovis aries
D-beta-fluoroalanine
-
Cricetulus griseus
D-beta-fluoroalanine
-
Bos taurus
D-beta-fluoroalanine
-
Oryctolagus cuniculus
D-beta-fluoroalanine
-
Ovis aries
D-cycloserine
-
Cricetulus griseus
D-cycloserine
-
Bos taurus
D-cycloserine
-
Oryctolagus cuniculus
D-cycloserine
-
Ovis aries
L-methionine
-
Saccharomyces cerevisiae
methyl methanethiosulfonate
-
Cricetulus griseus
methyl methanethiosulfonate
-
Bos taurus
methyl methanethiosulfonate
-
Oryctolagus cuniculus
methyl methanethiosulfonate
-
Ovis aries
S-adenosyl-L-methionine
-
Saccharomyces cerevisiae
tetrahydrofolate derivatives
-
Cricetulus griseus
tetrahydrofolate derivatives
-
Bos taurus
tetrahydrofolate derivatives
-
Oryctolagus cuniculus
tetrahydrofolate derivatives
-
Ovis aries
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Saccharomyces cerevisiae
additional information
-
additional information
pH-dependence of kinetic parameters
Cricetulus griseus
additional information
-
additional information
pH-dependence of kinetic parameters
Bos taurus
additional information
-
additional information
pH-dependence of kinetic parameters
Oryctolagus cuniculus
additional information
-
additional information
pH-dependence of kinetic parameters
Ovis aries
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Salmonella enterica subsp. enterica serovar Typhimurium
5737
-
cytoplasm
-
Cricetulus griseus
5737
-
cytoplasm
-
Saccharomyces cerevisiae
5737
-
cytoplasm
-
Bos taurus
5737
-
cytoplasm
-
Oryctolagus cuniculus
5737
-
cytoplasm
-
Neurospora crassa
5737
-
cytoplasm
-
Ovis aries
5737
-
mitochondrion
-
Saccharomyces cerevisiae
5739
-
mitochondrion
matrix
Cricetulus griseus
5739
-
mitochondrion
matrix
Bos taurus
5739
-
mitochondrion
matrix
Oryctolagus cuniculus
5739
-
mitochondrion
matrix
Ovis aries
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
L-serine + tetrahydrofolate
Saccharomyces cerevisiae
-
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Saccharomyces cerevisiae
?
L-serine + tetrahydrofolate
Salmonella enterica subsp. enterica serovar Typhimurium
may play important role in central nervous system
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium
?
L-serine + tetrahydrofolate
Cricetulus griseus
may play important role in central nervous system
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Cricetulus griseus
?
L-serine + tetrahydrofolate
Bos taurus
may play important role in central nervous system
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Bos taurus
?
L-serine + tetrahydrofolate
Oryctolagus cuniculus
may play important role in central nervous system
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Oryctolagus cuniculus
?
L-serine + tetrahydrofolate
Neurospora crassa
may play important role in central nervous system
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Neurospora crassa
?
L-serine + tetrahydrofolate
Ovis aries
may play important role in central nervous system
glycine + 5,10-methylenetetrahydrofolate + H2O
-
Ovis aries
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
ovary
-
Cricetulus griseus
-
Storage Stability (protein specific)
Storage Stability
Organism
frozen, several months at pH 7.3
Oryctolagus cuniculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
alpha-methylserine + tetrahydrofolate
-
441420
Salmonella enterica subsp. enterica serovar Typhimurium
D-alanine + 5,10-methylenetetrahydrofolate
-
441420
Salmonella enterica subsp. enterica serovar Typhimurium
?
alpha-methylserine + tetrahydrofolate
-
441420
Cricetulus griseus
D-alanine + 5,10-methylenetetrahydrofolate
-
441420
Cricetulus griseus
?
alpha-methylserine + tetrahydrofolate
-
441420
Saccharomyces cerevisiae
D-alanine + 5,10-methylenetetrahydrofolate
-
-
-
?
alpha-methylserine + tetrahydrofolate
-
441420
Bos taurus
D-alanine + 5,10-methylenetetrahydrofolate
-
441420
Bos taurus
?
alpha-methylserine + tetrahydrofolate
-
441420
Oryctolagus cuniculus
D-alanine + 5,10-methylenetetrahydrofolate
-
441420
Oryctolagus cuniculus
?
alpha-methylserine + tetrahydrofolate
-
441420
Neurospora crassa
D-alanine + 5,10-methylenetetrahydrofolate
-
441420
Neurospora crassa
?
alpha-methylserine + tetrahydrofolate
-
441420
Ovis aries
D-alanine + 5,10-methylenetetrahydrofolate
-
441420
Ovis aries
?
L-serine + tetrahydrofolate
-
441420
Salmonella enterica subsp. enterica serovar Typhimurium
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Salmonella enterica subsp. enterica serovar Typhimurium
?
L-serine + tetrahydrofolate
-
441420
Cricetulus griseus
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Cricetulus griseus
?
L-serine + tetrahydrofolate
-
441420
Saccharomyces cerevisiae
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Saccharomyces cerevisiae
?
L-serine + tetrahydrofolate
-
441420
Bos taurus
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Bos taurus
?
L-serine + tetrahydrofolate
-
441420
Oryctolagus cuniculus
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Oryctolagus cuniculus
r
L-serine + tetrahydrofolate
-
441420
Neurospora crassa
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Neurospora crassa
?
L-serine + tetrahydrofolate
-
441420
Ovis aries
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Ovis aries
r
L-serine + tetrahydrofolate
may play important role in central nervous system
441420
Salmonella enterica subsp. enterica serovar Typhimurium
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Salmonella enterica subsp. enterica serovar Typhimurium
?
L-serine + tetrahydrofolate
may play important role in central nervous system
441420
Cricetulus griseus
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Cricetulus griseus
?
L-serine + tetrahydrofolate
may play important role in central nervous system
441420
Bos taurus
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Bos taurus
?
L-serine + tetrahydrofolate
may play important role in central nervous system
441420
Oryctolagus cuniculus
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Oryctolagus cuniculus
?
L-serine + tetrahydrofolate
may play important role in central nervous system
441420
Neurospora crassa
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Neurospora crassa
?
L-serine + tetrahydrofolate
may play important role in central nervous system
441420
Ovis aries
glycine + 5,10-methylenetetrahydrofolate + H2O
-
441420
Ovis aries
?
additional information
-
441420
Saccharomyces cerevisiae
?
-
-
-
?
additional information
no: L-threonine
441420
Salmonella enterica subsp. enterica serovar Typhimurium
?
-
-
-
?
additional information
no: L-threonine
441420
Cricetulus griseus
?
-
-
-
?
additional information
no: L-threonine
441420
Bos taurus
?
-
-
-
?
additional information
no: L-threonine
441420
Oryctolagus cuniculus
?
-
-
-
?
additional information
no: L-threonine
441420
Neurospora crassa
?
-
-
-
?
additional information
no: L-threonine
441420
Ovis aries
?
-
-
-
?
additional information
no: D-serine
441420
Cricetulus griseus
?
-
-
-
?
additional information
no: D-serine
441420
Bos taurus
?
-
-
-
?
additional information
no: D-serine
441420
Oryctolagus cuniculus
?
-
-
-
?
additional information
no: D-serine
441420
Ovis aries
?
-
-
-
?
additional information
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
441420
Salmonella enterica subsp. enterica serovar Typhimurium
?
-
-
-
?
additional information
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
441420
Cricetulus griseus
?
-
-
-
?
additional information
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
441420
Bos taurus
?
-
-
-
?
additional information
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
441420
Oryctolagus cuniculus
?
-
-
-
?
additional information
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
441420
Neurospora crassa
?
-
-
-
?
additional information
enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate
441420
Ovis aries
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
homotetramer
-
Cricetulus griseus
homotetramer
-
Saccharomyces cerevisiae
homotetramer
-
Bos taurus
homotetramer
-
Oryctolagus cuniculus
homotetramer
-
Ovis aries
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
30
-
several h, pH 5.8-8.5, cytosol
Oryctolagus cuniculus
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
5.8
8.5
stable, rabbit cytosol
Oryctolagus cuniculus
Other publictions for EC 2.1.2.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
755905
Haque
Serine hydroxymethyltransfera ...
Bombyx mori, Bombyx mori p50T
Arch. Insect Biochem. Physiol.
102
e21594
2019
-
-
1
-
3
-
-
7
-
-
-
4
-
6
-
-
1
-
-
7
-
-
4
1
2
1
1
1
-
1
1
1
1
-
-
-
-
-
1
1
-
3
-
-
-
-
7
-
-
-
4
-
-
-
1
-
7
-
-
4
1
1
1
1
-
1
1
1
-
-
-
-
-
7
7
756725
Scaletti
Structural basis of inhibitio ...
Homo sapiens
FEBS Lett.
593
1863-1873
2019
-
-
1
1
-
-
4
-
1
-
-
2
-
3
-
-
1
-
-
-
-
-
2
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
4
-
-
1
-
-
2
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
757905
Li
Serine hydroxymethyltransfera ...
Aedes aegypti, Aedes aegypti NIH Rockefeller
Parasit. Vectors
12
460
2019
-
-
1
-
-
-
-
-
-
-
-
4
-
7
-
-
1
-
-
3
-
-
4
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
1
-
3
-
-
4
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
755964
Zhang
Structure and function of cyt ...
Komagataella pastoris, Komagataella pastoris X-33
Biochem. Biophys. Res. Commun.
496
753-757
2018
-
-
1
1
-
-
-
-
3
-
-
4
-
5
-
-
1
-
-
-
-
-
4
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
3
-
-
4
-
-
-
1
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
756058
Tramonti
Human cytosolic and mitochond ...
Homo sapiens
Biochemistry
57
6984-6996
2018
-
-
2
-
-
-
2
10
4
-
-
4
-
5
-
-
2
-
-
-
-
-
4
-
4
-
-
-
4
2
-
-
2
3
-
-
-
-
2
2
-
-
-
-
4
3
10
4
-
-
4
-
-
-
2
-
-
-
-
4
-
-
-
-
4
2
-
-
-
-
-
-
-
10
10
756705
Giardina
The catalytic activity of ser ...
Homo sapiens
FEBS J.
285
3238-3253
2018
-
-
1
1
3
-
-
3
2
-
-
2
-
1
-
-
1
-
-
3
-
-
2
1
3
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
3
-
-
-
-
3
2
-
-
2
-
-
-
1
-
3
-
-
2
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
756837
Ruszkowski
Chloroplastic serine hydroxym ...
Medicago truncatula
Front. Plant Sci.
9
584
2018
-
-
1
1
-
-
-
-
2
-
2
2
-
6
-
-
1
-
-
-
-
-
2
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
2
-
2
2
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
756948
Kumar
Improved catalytic properties ...
Idiomarina loihiensis
Int. J. Biol. Macromol.
117
1216-1223
2018
-
-
1
-
3
-
-
4
-
-
-
2
-
6
-
-
1
-
-
-
-
-
3
1
3
1
1
1
4
1
1
-
1
-
-
-
-
-
1
1
-
3
-
-
-
-
4
-
-
-
2
-
-
-
1
-
-
-
-
3
1
1
1
1
4
1
1
-
-
-
-
-
-
-
-
758178
Sodolescu
Structural and functional ins ...
Helicobacter pylori, Helicobacter pylori 26695
PLoS ONE
13
e0208850
2018
-
-
1
1
-
-
-
-
-
-
-
4
-
7
-
-
1
-
-
-
-
-
4
2
3
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
4
-
-
-
1
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
755894
Amornwatcharapong
Human and Plasmodium serine h ...
Homo sapiens, Plasmodium vivax
Arch. Biochem. Biophys.
630
91-100
2017
-
-
2
-
-
-
1
20
1
-
-
4
-
6
-
-
2
-
-
-
-
-
4
-
4
-
-
-
20
2
1
-
2
3
-
-
-
-
2
2
-
-
-
-
1
3
20
1
-
-
4
-
-
-
2
-
-
-
-
4
-
-
-
-
20
2
1
-
-
-
-
-
-
20
20
755912
Waditee-Sirisattha
Overexpression of halophilic ...
Aphanothece halophytica
Arch. Microbiol.
199
29-35
2017
-
-
1
-
-
-
-
-
-
-
-
2
-
13
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
758045
Kandoth
Systematic mutagenesis of ser ...
Glycine max
Plant Physiol.
175
1370-1380
2017
-
-
1
-
-
-
-
-
-
-
-
2
-
6
-
-
-
-
-
-
-
-
2
-
3
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
758412
Leng
Determinants of thermostabili ...
Geobacillus stearothermophilus
Sci. Rep.
7
46463
2017
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
756098
Paiardini
Differential 3-bromopyruvate ...
Homo sapiens
Biochim. Biophys. Acta
1864
1506-1517
2016
-
-
-
-
1
-
1
-
4
-
-
4
-
5
-
-
-
-
-
-
-
-
4
-
4
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
1
-
-
2
-
-
4
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735436
Huang
Characterization of a novel se ...
Arthrobacter sp., Arthrobacter sp. MCCC 1A05493
Ann. Microbiol.
65
1689-1698
2015
-
-
1
-
-
-
7
-
-
5
-
4
-
2
-
-
-
-
-
-
-
-
4
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
7
-
-
-
5
-
4
-
-
-
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
736499
Maenpuen
Kinetic mechanism and the rate ...
Plasmodium vivax
J. Biol. Chem.
290
8656-8665
2015
-
-
1
1
-
-
-
1
-
-
-
3
-
4
-
-
1
-
-
-
-
-
3
-
2
1
-
-
1
1
-
-
3
-
-
-
-
-
1
3
1
-
-
-
-
-
1
-
-
-
3
-
-
-
1
-
-
-
-
3
-
1
-
-
1
1
-
-
-
-
1
1
-
-
-
736882
Kim
SHMT2 drives glioma cell survi ...
Homo sapiens
Nature
520
363-367
2015
-
-
1
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
8
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
736925
Yin
Positive correlation between e ...
Homo sapiens
OncoTargets Ther.
8
1069-1074
2015
-
1
1
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
737188
Milano
Conserved water molecules in b ...
Burkholderia pseudomallei, Psychromonas ingrahamii, Rickettsia rickettsii, Burkholderia cenocepacia, Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli, Mycobacterium tuberculosis, Staphylococcus aureus, Thermus thermophilus, Geobacillus stearothermophilus, Campylobacter jejuni, Campylobacter jejuni ATCC 33560, Psychromonas ingrahamii 37, Burkholderia pseudomallei ATCC 23343, Mycobacterium tuberculosis H37Rv, Staphylococcus aureus COL, Rickettsia rickettsii Sheila Smith
Protein Eng. Des. Sel.
28
415-426
2015
-
11
-
-
-
-
-
-
-
-
-
17
-
19
-
-
-
-
-
-
-
-
17
11
22
-
-
-
-
-
-
-
33
-
-
-
-
11
-
33
-
-
-
-
-
-
-
-
-
-
17
-
-
-
-
-
-
-
-
17
11
-
-
-
-
-
-
-
-
-
33
33
-
-
-
755784
Hernandez
Engineered L-serine hydroxyme ...
Streptococcus thermophilus, Streptococcus thermophilus CNRZ 1066
Angew. Chem. Int. Ed. Engl.
54
3013-3017
2015
-
-
-
-
1
-
-
-
-
-
-
4
-
7
-
-
-
-
-
-
-
-
55
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
55
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
756288
Jiang
A novel serine hydroxymethylt ...
Glutamicibacter nicotianae
BMC Biotechnol.
14
93
2015
1
-
1
-
1
-
9
2
-
2
-
2
-
8
-
-
1
-
-
-
-
-
3
1
3
1
1
1
2
1
1
1
1
-
-
-
1
-
1
1
-
1
-
-
9
-
2
-
2
-
2
-
-
-
1
-
-
-
-
3
1
1
1
1
2
1
1
1
-
-
-
-
-
2
2
756477
Paiardini
Screening and in vitro testin ...
Homo sapiens
ChemMedChem
10
490-497
2015
-
-
-
-
-
-
5
-
3
-
-
2
-
4
-
-
1
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2
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2
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1
4
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1
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5
4
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2
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2
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Serine hydroxymethyltransfera ...
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2015
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1
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4
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4
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756695
Giardina
How pyridoxal 5'-phosphate di ...
Homo sapiens
FEBS J.
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2015
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4
2
4
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4
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2
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2
2
1
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4
6
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4
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2
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4
2
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4
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757362
Wang
Characterization and molecula ...
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2015
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1
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4
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2
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1
1
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757384
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Inhibitors of plasmodial seri ...
Plasmodium berghei, Plasmodium falciparum, Plasmodium vivax, Plasmodium vivax Salvador I
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8
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15
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3
1
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15
42
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8
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8
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730918
Angelucci
The crystal structure of archa ...
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Proteins
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2014
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1
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10
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2
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3
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1
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1
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-
2
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1
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1
1
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735367
Chitnumsub
Structures of Plasmodium vivax ...
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Acta Crystallogr. Sect. D
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1
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9
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4
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2
1
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1
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3
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3
1
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1
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4
-
1
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-
1
-
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1
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736084
Pinthong
Distinct biochemical propertie ...
Plasmodium falciparum, Plasmodium vivax, Homo sapiens
FEBS J.
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2014
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1
1
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13
1
6
3
4
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2
1
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9
-
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-
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1
1
9
-
-
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-
4
-
7
1
-
3
12
-
-
-
1
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-
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-
13
1
3
4
-
2
1
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5
5
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3
3
736645
Yuan
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A novel serine hydroxymethyltr ...
Alcanivorax sp.
J. Mol. Catal. B
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2014
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2
1
2
1
1
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1
1
1
3
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1
3
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-
-
2
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1
1
1
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-
-
-
-
2
1
1
1
-
-
1
1
1
-
-
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-
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736646
Angelaccio
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Structural stability of cold-a ...
Psychromonas ingrahamii, Escherichia coli, Psychromonas ingrahamii 37
J. Mol. Catal. B
110
171-177
2014
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8
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4
2
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2
2
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6
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6
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2
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4
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8
-
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8
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2
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-
2
2
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2
2
737212
Angelaccio
Conformational transitions dri ...
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Proteins
82
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2014
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10
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1
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1
1
2
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3
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1
3
1
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1
1
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1
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1
1
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3
3
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736727
di Salvo
Glycine consumption and mitoch ...
Homo sapiens
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1
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1
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2
2
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736753
Jiang
A serine hydroxymethyltransfer ...
Shewanella algae
Microbiol. Res.
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477-484
2013
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7
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1
3
1
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1
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1
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1
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3
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2
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1
3
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1
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8
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4
1
3
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1
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1
3
1
1
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1
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1
1
1
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737301
Jiang
Characterization of a serine h ...
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4
1
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1
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719472
Chiba
Mechanism for folate-independe ...
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4
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2
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2
1
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1
2
1
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2
2
719529
Waditee-Sirisattha
Overexpression of serine hydro ...
Aphanothece halophytica
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333
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1
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1
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1
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1
1
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1
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1
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1
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1
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1
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Anderson
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1
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2
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Zhao
Preparation of optically activ ...
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1
1
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718984
Florio
Serine hydroxymethyltransferas ...
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Engel
The presequence of Arabidopsis ...
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Structural adaptation of serin ...
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718775
Zhang
One-carbon metabolism in plant ...
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7
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3
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1
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2
3
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2
1
1
3
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5
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2
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7
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3
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3
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Alkaline pH-dependent differen ...
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2010
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2
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720362
Read
Dynamic subcellular localizati ...
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Malar. J.
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2010
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1
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1
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Pai
Structural and functional stud ...
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Florio
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Sopitthummakhun
Serine hydroxymethyltransferas ...
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1
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
704566
Fox
A UV-responsive internal ribos ...
Homo sapiens
J. Biol. Chem.
284
31097-31108
2009
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4
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4
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
704756
Schweitzer
The serine hydroxymethyltransf ...
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032
J. Biotechnol.
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214-221
2009
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-
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1
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2
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1
-
2
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
705602
Maenpuen
Characterization of Plasmodium ...
Plasmodium falciparum, Plasmodium falciparum TM4
Mol. Biochem. Parasitol.
168
63-73
2009
-
1
1
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1
1
5
-
-
2
-
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6
-
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1
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-
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4
1
2
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-
-
3
-
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1
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1
1
1
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1
-
1
-
5
-
-
2
-
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-
-
1
-
-
-
-
4
1
-
-
-
3
-
-
-
-
-
-
-
-
2
2
705603
Pang
Catalytic and ligand-binding c ...
Plasmodium falciparum
Mol. Biochem. Parasitol.
168
74-83
2009
-
-
1
-
-
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9
2
-
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2
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8
-
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1
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1
1
2
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-
1
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1
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9
-
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1
1
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9
9
-
2
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2
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1
-
-
-
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
689318
Leartsakulpanich
Cloning and characterization o ...
Plasmodium vivax
Parasitol. Int.
57
223-228
2008
-
-
1
-
1
-
-
-
1
-
-
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6
-
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1
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1
2
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1
-
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1
-
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-
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-
-
-
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-
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703629
Bhavani
Importance of tyrosine residue ...
Geobacillus stearothermophilus
FEBS J.
275
4606-4619
2008
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1
1
2
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6
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1
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2
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1
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1
1
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1
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-
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-
-
703863
Choi
-
Human serine hydroxymethyltran ...
Homo sapiens
Genes Genomics
30
541-548
2008
-
-
-
-
-
-
-
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1
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1
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1
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1
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2
-
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-
-
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-
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704347
Bhatt
Characterization of pyridoxal ...
Bacillus subtilis
J. Biochem.
144
295-303
2008
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-
1
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1
1
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7
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1
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1
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1
1
2
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1
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1
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1
1
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1
1
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1
1
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-
-
1
1
-
-
1
-
-
-
-
-
-
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-
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704435
MacFarlane
Cytoplasmic serine hydroxymeth ...
Mus musculus
J. Biol. Chem.
283
25846-25853
2008
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-
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3
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6
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2
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1
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2
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3
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2
-
-
1
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
671499
Stolz
Reduced folate supply as a key ...
Corynebacterium glutamicum
Appl. Environ. Microbiol.
73
750-755
2007
2
1
-
-
1
-
-
-
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-
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3
-
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1
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2
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1
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1
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1
-
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-
-
-
-
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-
-
-
-
-
-
-
-
673397
Zuo
-
Cloning, DNA shuffling and exp ...
Escherichia coli, Escherichia coli AB90054
Enzyme Microb. Technol.
40
569-577
2007
-
-
1
-
1
-
-
-
-
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1
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-
2
-
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1
-
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1
2
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1
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2
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1
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1
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1
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1
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-
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-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
676982
Vatsyayan
Molecular cloning and biochemi ...
Leishmania donovani, Leishmania donovani MHOM/IN/80/Dd8
Protein Expr. Purif.
52
433-440
2007
-
2
2
-
-
-
3
3
-
-
3
-
-
7
-
-
2
-
-
2
1
-
4
2
2
2
2
1
-
2
1
-
-
-
1
-
-
2
2
-
-
-
-
-
3
-
3
-
-
3
-
-
-
-
2
-
2
1
-
4
2
2
2
1
-
2
1
-
1
-
-
-
-
-
-
685708
Makart Stefa
Characterization of the AlkS/P ...
Escherichia coli
Biotechnol. Bioeng.
96
326-336
2007
-
1
1
-
-
-
-
-
-
-
-
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5
-
-
-
-
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-
1
-
1
-
2
-
-
-
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-
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1
1
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-
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-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686353
Chang
Serine hydroxymethyltransferas ...
Danio rerio
Drug Metab. Dispos.
35
2127-2137
2007
-
-
1
-
-
-
1
1
3
-
2
-
-
7
-
-
1
-
-
6
-
2
2
2
4
2
-
-
1
2
-
-
2
-
-
2
-
-
1
2
-
-
-
2
2
-
1
3
-
2
-
-
-
-
1
-
6
-
2
2
2
2
-
-
1
2
-
-
-
-
-
-
-
-
-
673412
Mukherjee
Identification and biochemical ...
Trichomonas vaginalis
Eukaryot. Cell
5
2072-2078
2006
1
1
1
-
2
-
-
4
3
-
1
-
-
6
-
-
1
-
-
-
-
-
1
1
2
-
-
-
4
-
-
-
-
-
-
-
1
1
1
-
-
2
-
-
-
-
4
3
-
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
4
-
-
-
-
-
-
-
-
-
-
674993
Franca
-
Molecular dynamics of the inte ...
Plasmodium falciparum, Homo sapiens
J. Braz. Chem. Soc.
17
1383-1392
2006
-
2
-
-
-
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2
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2
-
-
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-
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4
-
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2
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2
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675480
Griffiths
Lateral transfers of serine hy ...
Simkania negevensis, Waddlia chondrophila
J. Mol. Evol.
63
283-296
2006
-
2
-
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39
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-
-
-
-
-
-
-
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6
-
-
-
-
-
-
-
-
-
-
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-
2
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675874
Gagnon
Stage specific gene expression ...
Leishmania infantum, Leishmania major
Mol. Biochem. Parasitol.
150
63-71
2006
-
1
1
-
-
-
2
-
2
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2
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11
-
-
-
-
-
2
-
-
1
-
6
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
2
-
-
2
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676503
Schjoerring
Antisense reduction of serine ...
Solanum tuberosum
Plant J.
45
71-82
2006
-
-
1
-
-
-
-
-
1
-
1
-
-
4
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676615
Eisenhut
The plant-like C2 glycolate cy ...
Synechocystis sp.
Plant Physiol.
142
333-342
2006
-
1
1
-
1
-
-
-
-
-
1
-
-
11
-
-
1
-
-
-
-
-
1
1
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676954
Chang
Cloning, expression, purificat ...
Danio rerio, Danio rerio AB
Protein Expr. Purif.
46
212-220
2006
1
1
1
-
-
-
-
1
3
-
3
-
-
11
-
-
1
-
-
1
1
1
2
1
2
-
1
-
1
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
1
3
-
3
-
-
-
-
1
-
1
1
1
2
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
658127
Bhavani
Role of Lys-226 in the catalyt ...
Geobacillus stearothermophilus
Biochemistry
44
6929-6937
2005
-
-
-
1
2
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659572
Lewis
Low serine hydroxymethyltransf ...
Ovis aries, Homo sapiens, Rattus norvegicus
J. Clin. Endocrinol. Metab.
90
1594-1598
2005
-
-
-
-
-
-
-
-
-
-
-
3
-
11
-
-
-
-
-
7
-
-
3
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
7
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659772
Scheer
Activities of hepatic cytosoli ...
Rattus norvegicus
J. Nutr.
135
233-238
2005
-
-
-
-
-
-
-
-
6
-
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1
-
4
-
-
-
-
-
3
-
-
1
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
6
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660180
Moreno
Arabidopsis SHMT1, a serine hy ...
Arabidopsis thaliana, Arabidopsis thaliana C24
Plant J.
41
451-463
2005
-
-
1
-
-
-
-
-
-
-
-
2
-
7
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662384
Goyer
5-Formyltetrahydrofolate is an ...
Arabidopsis thaliana
J. Biol. Chem.
280
26137-26142
2005
-
-
-
-
1
-
1
-
1
-
-
-
-
3
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671589
Fu
Properties of human and rabbit ...
Homo sapiens, Oryctolagus cuniculus
Arch. Biochem. Biophys.
442
92-101
2005
2
-
2
-
4
-
-
6
6
-
-
-
-
10
-
-
2
-
-
-
-
-
4
-
4
-
-
-
6
-
-
-
-
-
-
-
2
-
2
-
-
4
-
-
-
-
6
6
-
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
674506
Perry
Mimosine attenuates serine hyd ...
Homo sapiens
J. Biol. Chem.
280
396-400
2005
-
1
1
-
1
-
1
-
1
1
-
-
-
8
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658083
Szebenyi
Serine hydroxymethyltransferas ...
Oryctolagus cuniculus
Biochemistry
43
6865-6876
2004
-
-
-
1
2
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
660460
Bhatt
The C-terminal domain of dimer ...
Geobacillus stearothermophilus, Bacillus subtilis
Protein Sci.
13
2184-2195
2004
-
-
-
-
2
2
-
-
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
2
2
-
-
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-
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2
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2
-
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-
-
726831
Buchenau
Tetrahydrofolate-specific enzy ...
Methanosarcina barkeri, Methanosarcina barkeri DSM 804
Arch. Microbiol.
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313-325
2004
-
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1
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1
2
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3
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3
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1
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4
2
4
1
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1
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1
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1
1
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1
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3
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1
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2
-
4
2
1
-
-
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1
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-
-
-
-
-
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-
657809
Schlpen
Disruption of the SHM2 gene, e ...
Eremothecium gossypii
Biochem. J.
369
263-273
2003
-
-
-
-
-
-
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1
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6
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1
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1
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1
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-
1
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-
657811
Jala
Identification of amino acid r ...
Ovis aries
Biochem. J.
369
469-476
2003
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-
-
-
13
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3
-
2
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4
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3
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1
1
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1
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1
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13
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3
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2
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3
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1
1
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-
658892
Jala
Disruption of distal interacti ...
Ovis aries
Indian J. Biochem. Biophys.
40
226-237
2003
-
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1
-
3
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4
4
-
2
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7
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4
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1
1
1
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2
4
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1
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3
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4
4
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2
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4
-
-
1
1
-
-
2
4
-
-
-
-
-
-
-
-
-
-
659226
Fu
Location of the pteroylpolyglu ...
Oryctolagus cuniculus
J. Biol. Chem.
278
2645-2653
2003
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-
-
1
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-
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3
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4
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1
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1
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1
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1
-
-
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-
-
659237
Fu
Role of proline residues in th ...
Escherichia coli
J. Biol. Chem.
278
31088-31094
2003
-
-
-
-
10
-
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18
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4
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1
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1
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3
18
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10
-
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-
18
-
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1
-
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-
-
1
-
-
-
3
18
-
-
-
-
-
-
-
-
-
-
659265
Chaturvedi
Unusual structural, functional ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Biol. Chem.
278
40793-40805
2003
-
-
2
-
-
4
-
-
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4
-
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10
-
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2
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8
2
6
-
-
2
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4
2
-
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2
2
-
-
4
-
-
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-
4
-
-
-
-
2
-
-
-
-
8
2
-
-
2
-
-
-
4
-
-
-
-
-
-
-
659269
Angelaccio
Catalytic and thermodynamic pr ...
Methanocaldococcus jannaschii
J. Biol. Chem.
278
41789-41797
2003
-
-
1
-
-
1
-
2
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-
2
-
-
12
-
-
1
-
-
-
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2
1
-
1
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-
2
-
-
-
-
-
-
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-
1
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-
-
1
-
-
-
2
-
-
2
-
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-
1
-
-
-
-
2
1
1
-
-
2
-
-
-
-
-
-
-
-
-
-
659754
Agrawal
Cloning, expression, activity ...
Escherichia coli, Homo sapiens
J. Mol. Microbiol. Biotechnol.
6
67-75
2003
-
2
1
-
-
-
-
-
1
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-
1
-
16
-
-
1
-
-
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-
-
3
-
2
-
-
-
-
-
-
-
2
-
-
-
-
2
1
2
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660469
Paiardini
Structural plasticity of therm ...
Aeropyrum pernix, Aquifex aeolicus, Archaeoglobus fulgidus, Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii, Pyrococcus abyssi, Pyrococcus horikoshii, Saccharolobus solfataricus, Thermotoga maritima, Methanothermobacter marburgensis
Proteins
50
122-134
2003
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
10
-
10
-
-
10
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
10
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
441431
Trivedi
Crystal structure of binary an ...
Geobacillus stearothermophilus
J. Biol. Chem.
277
17161-17169
2002
-
1
1
1
-
-
-
-
-
-
-
1
-
8
-
-
-
1
-
-
-
-
3
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441432
Jala
Overexpression and characteriz ...
Geobacillus stearothermophilus
J. Biosci.
27
233-242
2002
-
-
1
-
-
-
-
3
-
-
3
1
-
8
-
-
1
1
-
-
4
-
2
1
-
1
-
5
3
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
3
-
-
3
1
-
-
-
1
-
-
4
-
2
1
1
-
5
3
-
-
-
-
-
-
-
-
-
-
441424
Contestabile
L-Threonine aldolase, serine h ...
Escherichia coli
Eur. J. Biochem.
268
6508-6525
2001
-
-
1
-
-
-
1
-
-
-
-
-
-
6
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441427
Appaji Rao
Molecular organization, cataly ...
Saccharomyces cerevisiae, Oryctolagus cuniculus, Escherichia coli, Ovis aries, Homo sapiens, Pisum sativum
Int. J. Biochem. Cell Biol.
32
405-416
2000
-
6
4
1
-
-
36
-
11
-
-
6
-
13
-
5
-
-
-
-
6
-
24
11
-
-
-
-
-
-
-
-
12
-
-
-
-
6
4
12
1
-
-
-
36
-
-
11
-
-
6
-
-
5
-
-
-
6
-
24
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441428
Talwar
-
Role of Pro-297 in the catalyt ...
Ovis aries
Biochem. J.
350
849-853
2000
-
-
1
-
1
-
-
4
-
-
1
-
-
1
-
-
-
-
-
-
2
-
2
2
-
-
-
2
2
-
-
-
2
-
-
-
-
-
1
2
-
1
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
2
-
2
2
-
-
2
2
-
-
-
-
-
-
-
-
-
-
441429
Talwar
A change in reaction specifici ...
Ovis aries
Eur. J. Biochem.
267
929-934
2000
-
-
1
-
1
-
-
-
-
-
-
-
-
8
-
-
-
-
-
2
3
-
5
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
3
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441430
Rao
The role of Glu74 and Tyr82 in ...
Ovis aries
Eur. J. Biochem.
267
5967-5976
2000
-
1
1
-
3
-
-
3
4
-
2
1
-
12
-
-
-
1
-
4
3
-
2
2
-
-
1
2
3
-
-
-
1
-
-
-
-
1
1
1
-
3
-
-
-
-
3
4
-
2
1
-
-
-
-
-
4
3
-
2
2
-
1
2
3
-
-
-
-
-
-
-
-
-
-
441434
Ogawa
Serine hydroxymethyltransferas ...
Cricetulus griseus, Oryctolagus cuniculus, Escherichia coli, Ovis aries, Homo sapiens, Neurospora crassa, Vigna radiata, Pisum sativum, Rattus norvegicus
Int. J. Biochem. Cell Biol.
32
289-301
2000
-
5
4
2
-
-
9
-
-
-
7
9
-
20
-
-
-
15
-
-
7
-
34
8
-
-
-
-
-
-
-
-
8
-
-
-
-
5
4
8
2
-
-
-
9
-
-
-
-
7
9
-
-
-
-
-
-
7
-
34
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441436
Liu
Human cytoplasmic serine hydro ...
Homo sapiens
Biochemistry
39
11523-11531
2000
-
-
1
-
-
-
-
-
5
-
-
1
-
6
-
1
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
5
-
-
1
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441438
Vatcher
Identification and characteriz ...
Caenorhabditis briggsae, Caenorhabditis elegans
Gene
230
137-144
1999
-
-
2
-
-
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441423
Di Salvo
Purification and characterizat ...
Oryctolagus cuniculus
Protein Expr. Purif.
13
177-183
1998
-
-
1
-
-
-
-
2
6
-
-
2
-
9
-
-
1
-
-
2
1
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
6
-
-
2
-
-
-
1
-
2
1
-
3
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
441433
Liu
Gene cloning, nucleotide seque ...
Escherichia coli
Appl. Environ. Microbiol.
64
549-554
1998
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727262
Lin
Investigation of serine hydrox ...
Methanospirillum hungatei, Methanothrix soehngenii, Methanolobus tindarius, Methanosarcina barkeri, Methanospirillum hungatei GP1, Methanosarcina barkeri DSM 804
Can. J. Microbiol.
44
652-656
1998
-
-
-
-
-
-
-
4
-
-
-
-
-
27
-
-
-
-
-
-
-
-
6
-
4
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441422
Fratte
Purification and properties of ...
Saccharolobus solfataricus, Saccharolobus solfataricus P2
J. Bacteriol.
179
7456-7461
1997
-
-
-
-
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2
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2
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7
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1
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-
-
1
-
4
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
1
2
-
-
-
1
-
-
1
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441435
Chave
Isolation and characterization ...
Homo sapiens
Biochem. Soc. Trans.
25
53S
1997
-
-
1
-
-
-
-
-
3
-
-
1
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4
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-
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-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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441426
Brahatheeswaran
Interaction of sheep liver apo ...
Ovis aries
Arch. Biochem. Biophys.
330
363-372
1996
-
-
-
-
-
-
-
-
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3
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4
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-
-
1
-
-
-
-
-
-
-
2
-
-
-
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
441437
Sakamoto
-
Purification and characterizat ...
Euglena gracilis, Euglena gracilis Z
Biosci. Biotechnol. Biochem.
60
1941-1944
1996
-
-
-
-
-
-
9
2
3
-
2
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22
-
-
1
-
-
-
4
-
8
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
9
-
2
3
-
2
-
-
-
-
1
-
-
4
-
8
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
441421
Kruschwitz
Expression, purification, and ...
Homo sapiens
Protein Expr. Purif.
6
411-416
1995
-
-
1
-
-
-
-
2
5
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-
-
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9
-
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1
-
-
-
1
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
2
5
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
441425
Jagath-Reddy
cDNA cloning, overexpression i ...
Ovis aries
Eur. J. Biochem.
230
533-537
1995
-
-
1
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1
2
7
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1
1
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9
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1
-
-
6
4
-
2
1
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
1
-
2
7
-
1
1
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-
-
1
-
6
4
-
2
1
-
-
-
-
-
-
-
-
-
-
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441390
Ide
Purification of serine hydroxy ...
Geobacillus stearothermophilus
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203-209
1992
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1
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1
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1
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-
-
-
-
-
-
-
-
-
-
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-
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441409
Sakamoto
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Purification and characterizat ...
Euglena gracilis, Euglena gracilis Z
Agric. Biol. Chem.
55
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1991
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8
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1
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2
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8
1
-
-
-
-
-
1
-
-
2
4
-
-
-
-
-
2
-
-
-
-
9
4
1
1
-
2
-
-
-
-
1
-
-
2
-
8
1
-
-
-
-
1
-
-
-
-
-
-
-
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-
441417
Malthouse
A comparative study of the kin ...
Bos taurus
Biochem. J.
274
807-812
1991
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2
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1
1
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-
-
-
-
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-
-
1
-
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-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
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-
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441418
Stover
5-Formyltetrahydrofolate polyg ...
Oryctolagus cuniculus, Escherichia coli
J. Biol. Chem.
266
1543-1550
1991
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8
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2
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2
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-
2
-
-
-
-
-
-
-
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-
2
1
-
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-
-
-
2
-
-
-
-
8
1
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
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441405
Strong
Purification and properties of ...
Mus musculus
J. Biol. Chem.
265
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1990
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2
2
2
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4
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1
1
-
1
1
-
3
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
1
2
2
-
2
2
-
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-
1
-
1
1
-
3
1
-
-
-
1
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-
-
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391984
Bourguignon
Resolution and characterizatio ...
Pisum sativum
Biochem. J.
255
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1988
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3
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1
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1
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-
3
1
-
1
1
-
-
-
-
-
-
-
-
1
-
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-
-
1
-
-
-
-
-
-
-
3
-
1
-
-
-
-
1
-
3
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441391
Henricson
-
Serine hydroxymethyltransferas ...
Spinacia oleracea
Physiol. Plant.
74
602-606
1988
-
-
-
-
-
1
1
1
1
-
2
-
-
1
-
-
1
-
-
1
1
1
1
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
1
1
1
-
2
-
-
-
-
1
-
1
1
1
1
1
-
-
-
-
1
-
-
-
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-
-
-
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-
441398
Masuda
Affinity purification and char ...
Rattus norvegicus
J. Biochem.
101
643-652
1987
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-
-
-
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8
1
3
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2
1
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3
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1
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-
-
1
-
6
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
2
-
-
-
-
9
-
1
3
-
2
1
-
-
-
1
-
-
1
-
6
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
441410
Miyazaki
Purification and characterizat ...
Hyphomicrobium methylovorum
Eur. J. Biochem.
162
533-540
1987
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20
2
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3
1
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6
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1
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-
-
1
-
2
1
-
2
2
2
-
3
2
1
2
-
-
-
-
-
-
2
-
-
-
-
20
-
2
-
-
3
1
-
-
-
1
-
-
1
-
2
1
2
2
2
-
3
2
1
-
-
-
-
-
-
-
441411
Miyazaki
-
Futher characterization of ser ...
Hyphomicrobium methylovorum
Agric. Biol. Chem.
51
2587-2589
1987
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2
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1
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1
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-
4
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
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-
-
1
-
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-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441407
Mitchell
Serine hydroxymethyltransferas ...
Glycine max, Glycine max L. Merr. cv. Williams
Plant Physiol.
81
553-557
1986
-
-
-
-
-
1
8
3
-
-
2
2
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7
-
-
1
1
-
2
2
1
4
1
-
-
-
-
1
1
2
-
-
4
-
-
-
-
-
-
-
-
1
-
8
4
3
-
-
2
2
-
-
-
1
-
2
2
1
4
1
-
-
-
1
1
2
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-
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441412
Schirch
Serine hydroxymethyltransferas ...
Escherichia coli
J. Bacteriol.
163
1-7
1985
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1
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4
3
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1
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9
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1
1
-
-
1
-
3
2
-
-
-
-
2
-
-
1
3
-
-
-
-
-
1
3
-
-
-
-
4
-
3
-
-
4
1
-
-
-
1
-
-
1
-
3
2
-
-
-
2
-
-
1
-
-
-
-
-
-
-
441416
Manohar
Kinetic mechanism of the inter ...
Ovis aries
Biochemistry
23
4116-4122
1984
-
-
-
-
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2
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4
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1
-
1
-
-
1
-
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-
-
-
-
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-
-
1
-
-
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-
1
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2
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1
-
-
1
-
-
-
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-
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441393
Manohar
-
Purification, physicochemical ...
Ovis aries
J. Biosci.
4
31-50
1982
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-
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3
-
1
-
1
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1
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1
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-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
1
-
-
-
-
1
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
441408
Rao
Purification and regulatory pr ...
Vigna radiata
Plant Physiol.
69
11-18
1982
-
-
-
-
-
6
8
2
1
-
2
2
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6
-
-
1
-
-
1
1
-
3
1
-
2
1
-
-
1
1
-
1
2
-
-
-
-
-
1
-
-
6
-
8
2
2
1
-
2
2
-
-
-
1
-
1
1
-
3
1
2
1
-
-
1
1
-
-
-
-
-
-
-
-
441420
Schirch
Serine hydroxymethyltransferas ...
Bos taurus, Saccharomyces cerevisiae, Cricetulus griseus, Oryctolagus cuniculus, Ovis aries, Neurospora crassa, Salmonella enterica subsp. enterica serovar Typhimurium
Adv. Enzymol. Relat. Areas Mol. Biol.
53
83-112
1982
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22
5
12
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-
7
-
7
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-
-
12
-
1
-
1
37
5
-
-
-
1
-
-
-
1
18
-
-
-
-
-
-
18
-
-
-
-
22
-
5
12
-
-
7
-
-
-
-
-
1
-
1
37
5
-
-
1
-
-
-
1
-
-
-
-
-
-
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441399
Ogawa
Purification and characterizat ...
Rattus norvegicus, Rattus norvegicus Wistar
J. Biochem.
90
381-390
1981
-
-
-
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1
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6
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5
1
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171
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1
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-
1
1
-
12
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
1
-
-
6
-
5
1
-
-
-
1
-
1
1
-
12
2
-
-
-
-
1
-
-
-
-
-
-
-
-
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441394
Schirch
Purification and properties of ...
Oryctolagus cuniculus
J. Biol. Chem.
255
7801-7806
1980
-
-
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1
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4
2
3
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2
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1
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1
-
-
-
1
-
1
1
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
2
1
-
-
-
4
-
2
3
-
2
-
-
-
-
1
-
-
1
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
441403
Ramesh
Purification and physicochemic ...
Macaca radiata
Biochem. J.
187
623-636
1980
1
-
-
-
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4
8
1
3
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2
1
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6
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1
1
-
9
2
2
3
1
-
1
-
5
1
2
-
-
2
-
-
-
1
-
-
2
-
-
4
-
8
-
1
3
-
2
1
-
-
-
1
-
9
2
2
3
1
1
-
5
1
2
-
-
-
-
-
-
-
-
-
441404
Ramesh
Inhibition of monkey liver ser ...
Macaca radiata
Biochem. J.
187
249-252
1980
-
-
-
-
-
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1
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-
-
-
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6
-
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-
1
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441419
Akhtar
Mechanistic, inhibitory and st ...
Oryctolagus cuniculus
Biochem. J.
145
159-168
1975
-
-
-
-
-
-
5
-
5
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4
-
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-
2
-
1
1
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
5
-
-
5
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441413
Nakamura
Purification and characterizat ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae 3701B
Biochim. Biophys. Acta
327
328-335
1973
-
-
-
-
-
2
1
2
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3
1
2
-
3
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-
1
-
-
-
1
4
4
-
-
-
-
2
-
1
-
-
2
-
-
-
-
-
-
2
-
-
2
-
2
-
2
-
3
1
2
-
-
-
1
-
-
1
4
4
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
441415
El-Obeid
-
Glycidaldehyde, an inhibitor d ...
Oryctolagus cuniculus
Biochem. Soc. Trans.
1
1274-1276
1973
-
-
-
-
-
-
2
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441402
Akhtar
-
Interaction of serine transhyd ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
791
791-799
1972
-
-
-
-
-
-
4
-
1
-
-
-
-
1
-
-
1
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
5
-
-
1
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
441401
Fujioka
Purification and properties of ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
185
338-349
1969
-
-
-
1
-
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8
2
4
3
2
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1
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-
1
-
-
-
3
1
2
-
-
-
-
-
-
1
1
-
1
2
-
-
-
-
-
1
1
-
-
-
10
2
2
4
3
2
-
-
-
-
1
-
-
3
1
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
441400
Schirch
Serine transhydroxymethylase. ...
Oryctolagus cuniculus
J. Biol. Chem.
243
5651-5655
1968
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-
-
-
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8
1
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1
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-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
2
7
-
-
-
-
-
2
-
-
-
-
8
7
1
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-