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Literature summary for 2.1.2.1 extracted from
- Activities of hepatic cytosolic and mitochondrial forms of serine hydroxymethyltransferase and hepatic glycine concentration are affected by vitamin B-6 intake in rats (2005), J. Nutr., 135, 233-238.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | from rat liver fed dietary pyridoxine ranging from adequate to deficient levels, 2-0 mg pyridoxine per kg diet. SHMT activity increases with increasing dietary pyridoxine concentrations | Rattus norvegicus | 5829 | - |
| mitochondrion | from rat liver fed dietary pyridoxine ranging from adequate to deficient levels, 2-0 mg pyridoxine per kg diet. SHMT activity increases with increasing dietary pyridoxine concentrations. The mitochondrial isoenzyme comprises about 70% of the total activity | Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + glycine + H2O | Rattus norvegicus | the enzyme is a major source of one-carbon units for cellular metabolism. Potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake | tetrahydrofolate + L-Ser | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | from rats fed dietary pyridoxine ranging from adequare to deficient levels, 2-0 mg pyridoxine per kg diet | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + glycine + H2O | the enzyme is a major source of one-carbon units for cellular metabolism. Potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake | Rattus norvegicus | tetrahydrofolate + L-Ser | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| serine hydroxymethyltransferase | - |
Rattus norvegicus |
| SHMT | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | dependent on | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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