Literature summary for 2.1.2.1 extracted from

Paiardini, A.; Tramonti, A.; Schirch, D.; Guiducci, G.; di Salvo, M.L.; Fiascarelli, A.; Giorgi, A.; Maras, B.; Cutruzzola, F.; Contestabile, R.
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming (2016), Biochim. Biophys. Acta, 1864, 1506-1517 .

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Protein Variants

Protein Variants	Comment	Organism
A206C	the mutation yields an enzyme that forms a 3-bromopyruvate-enzyme complex and is completely inactivated	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
3-Bromopyruvate	isoform SHMT1 is completely inhibited by 3-bromopyruvate; isoform SHMT2 retains a significant fraction of activity with 3-bromopyruvate	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	isoform SHMT1	Homo sapiens	5829	-
mitochondrion	isoform SHMT2	Homo sapiens	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5,10-methylenetetrahydrofolate + glycine + H2O	Homo sapiens	-	tetrahydrofolate + L-serine	-	r
tetrahydrofolate + L-serine	Homo sapiens	-	5,10-methylenetetrahydrofolate + glycine + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P34896	-	-
Homo sapiens	P34897	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + glycine + H2O	-	Homo sapiens	tetrahydrofolate + L-serine	-	r
tetrahydrofolate + L-serine	-	Homo sapiens	5,10-methylenetetrahydrofolate + glycine + H2O	-	r

Synonyms

Synonyms	Comment	Organism
serine hydroxymethyltransferase	-	Homo sapiens
SHMT1	isoform	Homo sapiens
SHMT2	isoform	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Homo sapiens

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Release 2023.1 (January 2023)