Statistics (01.2022)

Increase in the data content of BRENDA in the last years

01.2015
07.2015 - 07.2021
01.2022
Increase from 01.2015 to 01.2022
ACTIVATING COMPOUNDS*
30727
38834
8107 (26%)
APPLICATIONS*
18531
28848
10317 (56%)
CAS REGISTRY NUMBERS*
4582
4525
-57 (-1%)
CLONED*
43704
71789
28085 (64%)
COFACTORS*
28270
55859
27589 (98%)
CRYSTALLIZATIONS*
12197
18675
6478 (53%)
EC CLASSES
6676
8283
1607 (24%)
ENGINEERING/MUTATIONS*
75579
116806
41227 (55%)
ENZYME SYNONYMS
165121
329248
164127 (99%)
EXPRESSION*
5676
12424
6748 (119%)
GENERAL INFORMATION*
22430
77328
54898 (245%)
GENERAL STABILITIES*
7819
8733
914 (12%)
IC50 VALUES*
46554
67930
21376 (46%)
INHIBITORS*
222505
293140
70635 (32%)
KCAT/KM VALUES*
16089
35568
19479 (121%)
KI VALUES*
37073
45684
8611 (23%)
KM VALUES*
136323
172917
36594 (27%)
LIGAND 2D STRUCTURES
1109169
159192
-949977 (-86%)
LIGANDS*
1471084
2597762
1126678 (77%)
LOCALIZATION*
36783
66943
30160 (82%)
METALS AND IONS*
44192
66685
22493 (51%)
NATURAL SUBSTRATES OF ENZYMATIC REACTIONS*
106517
267876
161359 (151%)
ORGANIC SOLVENT STABILITIES*
2452
3529
1077 (44%)
ORGANISM
1042556
15904516
14861960 (1426%)
OXIDATION STABILITIES*
767
956
189 (25%)
pH OPTIMA*
45234
57739
12505 (28%)
pH RANGES*
10375
12873
2498 (24%)
pH STABILITIES*
6938
8657
1719 (25%)
pI VALUES*
4758
6914
2156 (45%)
POSTTRANSLATIONAL MODIFICATIONS*
8086
12070
3984 (49%)
PURIFICATIONS*
43042
65478
22436 (52%)
REACTION TYPES*
11233
14370
3137 (28%)
REACTIONS
16429
22753
6324 (38%)
REFERENCE CITATIONS
197586
508633
311047 (157%)
REFERENCES
130406
163782
33376 (26%)
RENATURED*
1123
1381
258 (23%)
SEQUENCES
10236886
32296870
22059984 (215%)
SOURCE TISSUE*
97766
168643
70877 (72%)
SPECIFIC ACTIVITIES*
49897
59462
9565 (19%)
STORAGE STABILITIES*
10568
11345
777 (7%)
SUBSTRATES AND PRODUCTS
388771
512890
124119 (32%)
SUBUNITS*
44780
71920
27140 (61%)
TEMPERATURE OPTIMA*
29861
41043
11182 (37%)
TEMPERATURE RANGES*
4451
6455
2004 (45%)
TEMPERATURE STABILITIES*
20321
26553
6232 (31%)
TURNOVER NUMBERS*
59302
83662
24360 (41%)
* = The numbers denote the enzyme-organism-(protein-)commentary-reference-specific occurrences. For kinetic values (Km, Ki, kcat) and ligand-specific fields (Inhibitors, Activating Compounds, Ligands) the corresponding enzyme ligand is also taken into account.
For example, when the identical pI (isoelectric point) was measured for different enzymes or the identical enzyme from different organisms the information is included for each EC number and organism-specific enzyme isoform, respectively.