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Synonyms
glyoxalase i, glyoxalase 1, glo-1, glo-i, glo i, glyoxalase-i, glyoxalase-1, gly-i, lactoylglutathione lyase, glyoxylase i,
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ketone-aldehyde mutase
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lactoylglutathione lyase
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lactoylglutathione methylglyoxal lyase
lyase, lactoylglutathione
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rhGLO I
His-tagged GLO I protein
S-D-lactoylglutathione methylglyoxal lyase
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
S-D-lactoylglutathione:methylglyoxal lyase
Glo1
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Glo1
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650721, 664268, 690438, 694142, 707868, 709339, 709815, 710151, 729175, 729176, 729177, 729179, 729369, 729392
GloA
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GloA1
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GloA2
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GloA3
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GloI
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Glx-I
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GLXI
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Gly I
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glyoxalase I
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glyoxalase I
Amaranthus sp.
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glyoxalase I
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649441, 649677, 650721, 651571, 651577, 653583, 654009, 679014, 680638, 682102, 682254, 690442, 694142, 707014, 707602, 707837, 707868, 707962, 708320, 709339, 709445, 709654, 709815, 709820, 710567, 729175, 729176, 729177, 729179, 729369, 729392
glyoxalase-1
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glyoxalase-I
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glyoxylase I
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lactoylglutathione methylglyoxal lyase
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lactoylglutathione methylglyoxal lyase
Amaranthus sp.
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lactoylglutathione methylglyoxal lyase
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lactoylglutathione methylglyoxal lyase
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lactoylglutathione methylglyoxal lyase
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lactoylglutathione methylglyoxal lyase
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lactoylglutathione methylglyoxal lyase
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lactoylglutathione methylglyoxal lyase
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lactoylglutathione methylglyoxal lyase
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LGL
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione methylglyoxal lyase (isomerizing)
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S-D-lactoylglutathione:methylglyoxal lyase
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S-D-lactoylglutathione:methylglyoxal lyase
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STM3117
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YaiA
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
mechanism
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
mechanism
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
mechanism
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
mechanism
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
mechanism
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
mechanism
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
mechanism
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
mechanism
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
mechanism
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
there is a single site for the binding of the hemimercaptal of methylglyoxal and glutathione, for the binding of glutathione, and for the binding of S-substituted derivatives of glutathione. One-substrate reaction mechanism with hemimercaptal being the substrate, but does not rule out the possibility of the alternate branches
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
intramolecular hydride migration is the rate-determining step
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
comparative study of methylgloxal metabolism in trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi und Leishmania major. Trypanosoma brucei lacks GLO1 activity. Overexpression of GLO1 from Trypanosoma cruzi in Trypanosoma brucei results in restoration of the glyoxalase system resulting in an increased resistance to methylglyoxal and increased conversion of methylglyoxal to D-lactate, demonstratong that glyoxalase II (GLO2, EC 3.1.2.6) is functional in vivo
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
comparative study of methylgloxal metabolism in trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi und Leishmania major. Trypanosoma brucei lacks GLO1 activity. Overexpression of GLO1 from Trypanosoma cruzi in Trypanosoma brucei results in restoration of the glyoxalase system resulting in an increased resistance to methylglyoxal and increased conversion of methylglyoxal to D-lactate, demonstratong that glyoxalase II (GLO2, EC 3.1.2.6) is functional in vivo
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
investigation of the biological role of GLO I in renal hypoxic diseases by using the rat ischemia/reperfusion (I/R) injury model. I/R induces the reduction of renal GLO I activity associated with morphological changes and renal dysfunction
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
methylglyoxal and glutathione form an intermediate, the hemithioacetal, which is catalyzed to S-D-lactoylglutathione by GlxI. Subsequently S-D-lactoylglutathione is hydrolyzed to D-lactate and glutathione by GlxII (EC 3.1.2.6)
(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
comparative study of methylgloxal metabolism in trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi und Leishmania major. Trypanosoma brucei lacks GLO1 activity. Overexpression of GLO1 from Trypanosoma cruzi in Trypanosoma brucei results in restoration of the glyoxalase system resulting in an increased resistance to methylglyoxal and increased conversion of methylglyoxal to D-lactate, demonstratong that glyoxalase II (GLO2, EC 3.1.2.6) is functional in vivo
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(R)-S-lactoylglutathione
glutathione + methylglyoxal
gamma-glutamylcysteine-methylglyoxal hemithioacetal
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gamma-glutamylcysteine-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
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gamma-glutamylcysteine-phenylglyoxal hemithioacetal
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gamma-glutamylcysteine-phenylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
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glutathione + 2,4-dimethylphenylglyoxal
S-(2,4-dimethyl)mandeloylglutathione
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glutathione + 2-oxopropanal
(R)-S-lactoylglutathione
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r
glutathione + 4,5-dioxovalerate
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glutathione + 4-bromophenylglyoxal
S-(4-bromo)mandeloylglutathione
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glutathione + 4-methylphenylglyoxal
S-(4-methyl)mandeloylglutathione
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glutathione + bromophenylglyoxal
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glutathione + glyoxal
S-glycolylglutathione
glutathione + hydroxypyruvaldehyde
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glutathione + m-methoxyphenylglyoxal
S-(3-methoxy)mandeloylglutathione
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glutathione + methylglyoxal
(R)-S-lactoylglutathione
glutathione + methylglyoxal
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glutathione + methylglyoxal
S-((R)-lactoyl)glutathione
glutathione + methylglyoxal
S-D-lactoylglutathione
glutathione + methylglyoxal
S-lactoylglutathione
glutathione + methylphenylglyoxal
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glutathione + p-chlorophenylglyoxal
S-(4-chloro)mandeloylglutathione
glutathione + p-hydroxyphenylglyoxal
S-(4-hydroxy)mandeloylglutathione
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glutathione + p-methoxyphenylglyoxal
S-(4-methoxy)mandeloylglutathione
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glutathione + p-phenylphenylglyoxal
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glutathione + phenylglyoxal
S-mandeloylglutathione
glutathione + phenylglyoxal
S-mandoylglutathione
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glutathione ethyl ester + methylglyoxal
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glutathione ethyl ester + methylglyoxal
S-lactoylglutathionyl ethyl ester
glutathione isopropyl ester + methylglyoxal
S-lactoylglutathionyl isopropyl ester
glutathione-glyoxal hemithioacetal
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glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
glutathione-phenylglyoxal hemithioacetal
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glutathionylspermidine + methylglyoxal
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glutathionylspermidine + phenylglyoxal
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homoglutathione-methylglyoxal hemithioacetal
(R)-S-lactoylhomoglutathione
homoglutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
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homoglutathione-phenylglyoxal hemithioacetal
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homoglutathione-phenylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
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methylglyoxal + glutathione
(R)-S-lactoylglutathione
methylglyoxal + glutathione
(R)S-lactoylglutathione
Amaranthus sp.
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first step in the glyoxalase system
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r
methylglyoxal + glutathione
S-((R)-lactoyl)glutathione
methylglyoxal + glutathione
S-D-lactoylglutathione
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methylglyoxal + reduced trypanothione
S-D-lactoyltrypanothione
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methylglyoxal + trypanothione
S,S'-bis((R)-lactoyl)trypanothione
N1-glutathionylspermidine + methylglyoxal
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S-D-lactoyltrypanothione
methylglyoxal + reduced trypanothione
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S-mandoylglutathione
glutathione + phenylglyoxal
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S-mandoyltrypanothione
phenylglyoxal + trypanothione
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trypanothione + 2 methylglyoxal
5,5'-bi((R)-lactoyl)trypanothione
trypanothione + methylglyoxal
5,5'-bi((R)-lactoyl)trypanothione
trypanothione + methylglyoxal
S,S'-bis((R)-lactoyl)trypanothione
trypanothione + phenylglyoxal
S-mandoyltrypanothione
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additional information
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(R)-S-lactoylglutathione
glutathione + methylglyoxal
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(R)-S-lactoylglutathione
glutathione + methylglyoxal
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(R)-S-lactoylglutathione
glutathione + methylglyoxal
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(R)-S-lactoylglutathione
glutathione + methylglyoxal
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r
(R)-S-lactoylglutathione
glutathione + methylglyoxal
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(R)-S-lactoylglutathione
glutathione + methylglyoxal
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(R)-S-lactoylglutathione
glutathione + methylglyoxal
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r
(R)-S-lactoylglutathione
glutathione + methylglyoxal
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(R)-S-lactoylglutathione
glutathione + methylglyoxal
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glutathione + 4,5-dioxovalerate
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glutathione + 4,5-dioxovalerate
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glutathione + 4,5-dioxovalerate
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glutathione + 4,5-dioxovalerate
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no activity
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glutathione + 4,5-dioxovalerate
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glutathione + glyoxal
S-glycolylglutathione
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glutathione + glyoxal
S-glycolylglutathione
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glutathione + glyoxal
S-glycolylglutathione
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4.4.1.5 lactoylglutathione lyase
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