Literature summary for 2.3.1.B41 extracted from

Chen, X.; Hao, B.; Liu, Y.; Dai, D.; Han, G.; Li, Y.; Wu, X.; Zhou, X.; Yue, Z.; Wang, L.; Cao, Y.; Liu, J.
The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma (2014), Biochem. Biophys. Res. Commun., 446, 364-369.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N6T7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
glioma cell	SIRT6 is down-regulated in human glioma tissues	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
SIRT6	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	SIRT6 is down-regulated in human glioma tissues	down

General Information

General Information	Comment	Organism
metabolism	SIRT6 acts as a tumor suppressor in human glioma. SIRT6 binds to poly(C)-binding protein 2 (PCBP2) promoter region and deacetylates H3K9ac, resulting in transcription regression	Homo sapiens

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Release 2023.1 (January 2023)