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Information on EC 3.1.3.7 - 3'(2'),5'-bisphosphate nucleotidase
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3.1.3.7 3'(2'),5'-bisphosphate nucleotidaseIUBMB Comments
Also acts on 3'-phosphoadenylyl sulfate, and on the corresponding 2'-phosphates.
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Word Map
- 3.1.3.7
-
phosphatidic
-
1-phosphatase
-
3'2',5'-bisphosphate
- 5'-phosphosulfate
- 3'-phosphoadenosine-5'-phosphate
- exoribonuclease
-
lithium-sensitive
- medicine
- synthesis
- biotechnology
- pharmacology
The enzyme appears in viruses and cellular organisms
Synonyms
papase, pap phosphatase, bpnt1, rv2837c, fiery1, met22, 3'(2'),5'-bisphosphate nucleotidase, gpapp, bpnt-1, bpntase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3'(2'),5'-bisphosphate nucleotidase
3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase
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-
-
-
3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase
-
-
-
-
3',5'-bisphosphate nucleotidase
3'-phosphoadenosine-5'-phosphatase
3'-phosphoadenylylsulfate 3'-phosphatase
-
-
-
-
3(2),5-bisphosphate nucleotidase
adenosine-3',5'-bisphosphate 3'-phosphohydrolase
-
-
-
-
bisphosphate 3'-nucleotidase
BPNT-1
BPNT1
BPntase
Cv1693
CysQ
DPNPase
-
-
-
-
GhHL1
Halotolerance protein tol1
-
-
-
-
MTCY270.37
NrnA
nucleotidase, phosphoadenylate 3'-
-
-
-
-
PDE2
phosphoadenylate 3'-nucleotidase
-
-
-
-
Rv2131c
Rv2837c
3'(2'),5'-bisphosphate nucleotidase
gene FIERY1, dual enzymatic activity: inositol polyphosphate-1-phosphatase
CysQ
-
exhibits also NADP(H) phosphatase and fructose-1,6-bisphosphatase activities
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
adenosine 3',5'-bisphosphate + H2O = AMP + phosphate
-
-
-
-
adenosine 3',5'-bisphosphate + H2O = AMP + phosphate
mechanism
adenosine 3',5'-bisphosphate + H2O = AMP + phosphate
proposed catalytic mechanism for CysQ, Asp50 deprotonates Thr96 that deprotonates the water (ligating a Mg2+), which attacks the phosphate, the pentacovalent 3'-phosphate transition state is stabilized by the three Mg2+ ions, overview
adenosine 3',5'-bisphosphate + H2O = AMP + phosphate
proposed catalytic mechanism for CysQ, Asp50 deprotonates Thr96 that deprotonates the water (ligating a Mg2+), which attacks the phosphate, the pentacovalent 3'-phosphate transition state is stabilized by the three Mg2+ ions, overview
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase
Also acts on 3'-phosphoadenylyl sulfate, and on the corresponding 2'-phosphates.
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CAS REGISTRY NUMBER
COMMENTARY
9025-83-6
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-deoxyguanosine 3',5'-bisphosphate + H2O
2'-deoxyguanosine 5'-phosphate + phosphate
-
-
-
?
2'-deoxythymidine 3',5'-bisphosphate + H2O
2'-deoxythymidine 5'-phosphate + phosphate
-
-
-
?
2'-deoxyuridine 3',5'-bisphosphate + H2O
2'-deoxyuridine 5'-phosphate + phosphate
-
-
-
?
3'-phosphoadenosine 5'-phosphate + H2
AMP + phosphate
-
-
-
?
5'-phosphoadenylyl-(3'->5')-adenosine + H2O
? + phosphate
-
-
-
?
cytidine 3',5'-bisphosphate + H2O
cytidine 5'-phosphate + phosphate
-
-
-
?
D-myo-inositol 2-phosphate + H2O
D-myo-inositol + phosphate
-
9% relative activity compared to NADP+
-
-
?
D-myo-inositol-1,4,5-trisphosphate + H2O
?
-
14% relative activity compared to NADP+
-
-
?
D-myo-inositol-1,4-bisphosphate + H2O
?
-
485% relative activity compared to NADP+
-
-
?
guanosine 2',5'-bisphosphate + H2O
guanosine 2'-phosphate + phosphate
-
-
-
?
N6-methyl-5'-phosphoadenylyl-(3'->5')-adenosine + H2O
? + phosphate
-
-
-
?
NADPH + H2O
NADH + phosphate
-
145% relative activity compared to NADP+
-
-
?
p-nitrophenyl phosphate
p-nitrophenol + phosphate
-
21% relative activity compared to NADP+
-
-
?
thymidine 3',5'-bisphosphate + H2O
thymidine 5'-phosphate + phosphate
-
-
-
?
uridine 3',5'-bisphosphate + H2O
uridine 5'-phosphate + phosphate
-
-
-
?
2'-deoxyadenosine 3',5'-bisphosphate + H2O
2'-deoxyadenosine 5'-phosphate + phosphate
-
-
-
?
2'-deoxyadenosine 3',5'-bisphosphate + H2O
2'-deoxyadenosine 5'-phosphate + phosphate
-
-
-
?
2'-deoxycytidine 3',5'-bisphosphate + H2O
2'-deoxycytidine 5'-phosphate + phosphate
-
-
-
?
2'-deoxycytidine 3',5'-bisphosphate + H2O
2'-deoxycytidine 5'-phosphate + phosphate
-
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
67% enzyme activity in comparison to 3'-phosphoadenosine 5'-phosphate as substrate
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
829% relative activity compared to NADP+
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
100% in comparison to 3'-phosphoadenosine 5'-phosphate as substrate
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
only 6% enzyme activity in comparison to 3'-phosphoadenosine 5'-phosphate as substrate
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
100% activity
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
607% relative activity compared to NADP+
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
the activity of enzyme is required while 3'-phosphoadenosine 5'-phosphate is a potent inhibitor of a variety of enzymes that use 3'-phosphoadenosine 5'-phosphate as cosubstrate
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?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
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-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
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-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
best substrate
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-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
best substrate
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-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
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-
?
adenosine 3',5'-bisphosphate + H2O
AMP + phosphate
i.e. PAP
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?
adenosine 3',5'-bisphosphate + H2O
AMP + phosphate
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-
-
?
adenosine 3',5'-bisphosphate + H2O
AMP + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
AMP + phosphate
i.e. PAP
-
-
?
adenosine 3',5'-bisphosphate + H2O
AMP + phosphate
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-
-
?
adenosine 3',5'-bisphosphate sulfate + H2O
adenosine 5'-phosphate sulfate + phosphate
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-
-
?
adenosine 3',5'-bisphosphate sulfate + H2O
adenosine 5'-phosphate sulfate + phosphate
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-
-
?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
-
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?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
42% activity compared to adenosine 3',5'bisphosphate
-
-
?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
-
?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
-
?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
-
?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
-
?
D-fructose 1,6-bisphosphate + H2O
?
-
122% relative activity compared to NADP+
-
-
?
D-myo-inositol monophosphate + H2O
D-myo-inositol + phosphate
-
13% relative activity compared to NADP+
-
-
?
D-myo-inositol monophosphate + H2O
D-myo-inositol + phosphate
-
-
-
?
D-myo-inositol monophosphate + H2O
D-myo-inositol + phosphate
-
-
-
?
guanosine 3',5'-bisphosphate + H2O
guanosine 5'-phosphate + phosphate
-
-
-
?
guanosine 3',5'-bisphosphate + H2O
guanosine 5'-phosphate + phosphate
-
-
-
?
guanosine 3',5'-bisphosphate + H2O
guanosine 5'-phosphate + phosphate
-
-
-
?
inositol 1,3,4-trisphosphate + H2O
inositol 3,4-bisphosphate + phosphate
-
-
-
-
?
inositol 1,3,4-trisphosphate + H2O
inositol 3,4-bisphosphate + phosphate
-
-
?
inositol 1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
-
-
-
?
inositol 1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
-
?
inositol 1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
-
-
?
inositol 1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
-
?
inositol-1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
5.6% activity compared to adenosine 3',5'bisphosphate
-
-
?
inositol-1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
-
?
additional information
?
-
enzyme is promiscuous and is able to hydrolyze several 3',5'-bisphosphonucleotides such as pGp, pCp, pUp, and pIp, and 2'-deoxynucleotides with comparable catalytic efficiency. In addition, it is capable of hydrolyzing short oligonucleotides such as (pdA)5, albeit at rates much lower than that of adenosine 3',5'-bisphosphate
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-
?
additional information
?
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enzyme is promiscuous and is able to hydrolyze several 3',5'-bisphosphonucleotides such as pGp, pCp, pUp, and pIp, and 2'-deoxynucleotides with comparable catalytic efficiency. In addition, it is capable of hydrolyzing short oligonucleotides such as (pdA)5, albeit at rates much lower than that of adenosine 3',5'-bisphosphate
-
-
?
additional information
?
-
enzyme is promiscuous and is able to hydrolyze several 3',5'-bisphosphonucleotides such as pGp, pCp, pUp, and pIp, and 2'-deoxynucleotides with comparable catalytic efficiency. In addition, it is capable of hydrolyzing short oligonucleotides such as (pdA)5, albeit at rates much lower than that of adenosine 3',5'-bisphosphate
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-
?
additional information
?
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-
glycerol phosphate, D-glucose-1-phosphate, D-glucose-6-phosphate, D-fructose-1-phosphate, D-fructose 1,6-bisphosphate, D-fructose-6-phosphate, ADP, 5'-AMP, ATP, NAD+, NMN+, bis-p-nitrophenol phosphate are no substrates
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-
?
additional information
?
-
GhHL1 protein efficiently hydrolyzes 3'(2'),5'-bisphosphate nucleotide and 3'(2'),5'-bisphosphate nucleotide sulfate, at 128% of 3'(2'),5'-bisphosphate nucleotide levels, but has low or no activity with other tested compounds including 3'-AMP, 5'-AMP, or ADP. Purified recombinant GhHL1 protein dephosphorylates both 3',5'-bisphosphate nucleotide and inositol 1,4-bisphosphate, demonstrating dual 3',5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase activities, substrate specificity, overview
-
-
?
additional information
?
-
-
GhHL1 protein efficiently hydrolyzes 3'(2'),5'-bisphosphate nucleotide and 3'(2'),5'-bisphosphate nucleotide sulfate, at 128% of 3'(2'),5'-bisphosphate nucleotide levels, but has low or no activity with other tested compounds including 3'-AMP, 5'-AMP, or ADP. Purified recombinant GhHL1 protein dephosphorylates both 3',5'-bisphosphate nucleotide and inositol 1,4-bisphosphate, demonstrating dual 3',5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase activities, substrate specificity, overview
-
-
?
additional information
?
-
GhHL1 protein efficiently hydrolyzes 3'(2'),5'-bisphosphate nucleotide and 3'(2'),5'-bisphosphate nucleotide sulfate, at 128% of 3'(2'),5'-bisphosphate nucleotide levels, but has low or no activity with other tested compounds including 3'-AMP, 5'-AMP, or ADP. Purified recombinant GhHL1 protein dephosphorylates both 3',5'-bisphosphate nucleotide and inositol 1,4-bisphosphate, demonstrating dual 3',5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase activities, substrate specificity, overview
-
-
?
additional information
?
-
3'-phosphoadenosine 5'-phosphate 3'-phosphatase plays a role in the formation of skeletal elements derived through endochondral ossification
-
-
?
additional information
?
-
enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60
-
-
?
additional information
?
-
-
enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60
-
-
?
additional information
?
-
Mtb CysQ can dephosphorylate myo-inositol 1-phosphate (IMP), fructose 1,6-bisphosphate (FBP), and 3'-phosphoadenosine 5'-monophosphate (PAP), but the catalytic efficiency is 1700 and 15000fold greater for PAP over FBP and IMP, respectively. AMP and phosphate enzyme binding structures, overview. The specificity of a 5'-phosphate or bis-phosphate sugars for CysQ can likely come from a conserved positively charged residue, Lys190 in CysQ, that ion pairs with the nonhydrolyzed phosphate
-
-
?
additional information
?
-
-
Mtb CysQ can dephosphorylate myo-inositol 1-phosphate (IMP), fructose 1,6-bisphosphate (FBP), and 3'-phosphoadenosine 5'-monophosphate (PAP), but the catalytic efficiency is 1700 and 15000fold greater for PAP over FBP and IMP, respectively. AMP and phosphate enzyme binding structures, overview. The specificity of a 5'-phosphate or bis-phosphate sugars for CysQ can likely come from a conserved positively charged residue, Lys190 in CysQ, that ion pairs with the nonhydrolyzed phosphate
-
-
?
additional information
?
-
enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60
-
-
?
additional information
?
-
Mtb CysQ can dephosphorylate myo-inositol 1-phosphate (IMP), fructose 1,6-bisphosphate (FBP), and 3'-phosphoadenosine 5'-monophosphate (PAP), but the catalytic efficiency is 1700 and 15000fold greater for PAP over FBP and IMP, respectively. AMP and phosphate enzyme binding structures, overview. The specificity of a 5'-phosphate or bis-phosphate sugars for CysQ can likely come from a conserved positively charged residue, Lys190 in CysQ, that ion pairs with the nonhydrolyzed phosphate
-
-
?
additional information
?
-
adenosine 3',5'-bisphosphate is not the primary substrate, the enzyme may be important for response to salt stress
-
-
?
additional information
?
-
-
adenosine 3',5'-bisphosphate is not the primary substrate, the enzyme may be important for response to salt stress
-
-
?
additional information
?
-
isoform additonally hydrolyses cyclic di-AMP, reaction of EC 3.1.4.59. No substrate: ATP
-
-
?
additional information
?
-
isoform additonally hydrolyses cyclic di-AMP, reaction of EC 3.1.4.59. No substrate: ATP
-
-
?
additional information
?
-
not: 3-AMP, ATP, NADP, O-phospho-L-serine, phosphoglycolic acid, L-histidinol phosphate
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
the activity of enzyme is required while 3'-phosphoadenosine 5'-phosphate is a potent inhibitor of a variety of enzymes that use 3'-phosphoadenosine 5'-phosphate as cosubstrate
-
?
adenosine 3',5'-bisphosphate + H2O
AMP + phosphate
-
-
-
?
additional information
?
-
3'-phosphoadenosine 5'-phosphate 3'-phosphatase plays a role in the formation of skeletal elements derived through endochondral ossification
-
-
?
additional information
?
-
adenosine 3',5'-bisphosphate is not the primary substrate, the enzyme may be important for response to salt stress
-
-
?
additional information
?
-
-
adenosine 3',5'-bisphosphate is not the primary substrate, the enzyme may be important for response to salt stress
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Mg2+
Mn2+
enzyme has a trinuclear metal center in the active site with three Mn2+ ions
additional information
Mg2+
the activity increases over increasing concentrations of Mg2+ to reach its optimal values in the presence of 2 to 2.5 mM Mg2+
Mg2+
-
in the presence of 10 mM MgCl2, CysQ shows maximum activities of 3'-PAPase and NADP(H)ase at pH 6.4 and pH 8.0, respectively
Mg2+
required for activity, optimal activity observed between pH 8.5 and pH 9.5, using 0.5 mM Mg2+
Mg2+
activates, three Mg2+ ions binding in the active site are required to form a productive enzyme, enzyme binding structure, overview
additional information
GhHL1 is Mg2+-dependent and cation-sensitive
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Mg2+
-
activity is decreased to approximately 70% in the presence of 10 mM MgCl2
Ca2+
competitive to Mg2+. Inhibition by Ca2+can be prevented by addition of Mg2+
Li+