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Information on EC 2.7.8.11 - CDP-diacylglycerol-inositol 3-phosphatidyltransferase
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2.7.8.11 CDP-diacylglycerol-inositol 3-phosphatidyltransferaseSpecify your search results
Word Map
- 2.7.8.11
- phosphatidylserine
-
3hinositol
-
inositol-containing
-
phospholipid-synthesizing
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cdp-dag
- inositol-1-phosphate
-
uasino
-
o-phosphatidyltransferase
-
3hptdins
- medicine
- agriculture
The enzyme appears in viruses and cellular organisms
Synonyms
phosphatidylinositol synthase, pi synthase, ptdins synthase, cdipt, zmpis, cdp-diglyceride:inositol transferase, cdp-dg:inositol transferase, pkpis, cdp-diacylglycerol-inositol 3-phosphatidyltransferase, bnptdins s1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CDP-DG:inositol transferase
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CDP-diacylglacerol: myo-inositol 3-phosphatidyl-transferase
CDP-diacylglycerol-inositol phosphatidyltransferase
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CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase
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CDP-diglyceride-inositol phosphatidyltransferase
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CDP-diglyceride-inositol transferase
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CDP-diglyceride:inositol transferase
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CDPdiglyceride-inositol phosphatidyltransferase
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cytidine 5'-diphospho-1,2-diacyl-sn-glycerol: myoinositol 3-phosphatidyl transferase
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cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase
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cytidine diphosphodiglyceride-inositol phosphatidyltransferase
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cytidine diphosphoglyceride-inositol phosphatidyltransferase
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cytidine diphosphoglyceride-inositol transferase
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phosphatidyinositol synthase
phosphatidylinositol synthase
PI synthase
PIS
PIS1
PIS2
PtdIn synthase
PtdIns synthase
PtIns synthase
ZmPIS
phosphatidylinositol synthase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
CDP-diacylglycerol + myo-inositol = CMP + 1-phosphatidyl-1D-myo-inositol
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
substituted phospho group transfer
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase
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CAS REGISTRY NUMBER
COMMENTARY
9027-01-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-stearoyl-2-arachidonoylphosphatidylinositol + CMP
CDP-1-stearoyl-2-arachidonoylglycerol + myo-inositol
-
-
-
r
CDP-1-arachidonoyl-2-stearoylglycerol + myo-inositol
CMP + 1-arachidonoyl-2-stearoylphosphtidylinositol
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6% of the activity with CDP-1-stearoyl-2-oleoylglycerol
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-
r
CDP-1-stearoyl-2-arachidonoylglycerol + myo-inositol
CMP + 1-stearoyl-2-arachidonoylphosphatidylinositol
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4% of the activity with CDP-1-stearoyl-2-oleoylglycerol
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-
r
CDP-1-stearoyl-2-oleoylglycerol + myo-inositol
CMP + 1-stearoyl-2-oleoylphosphatidylinositol
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-
-
-
r
CDP-diacylglycerol + 1D-chiro-inositol
CMP + phosphatidyl-1D-chiro-inositol
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conversion of 30.9% CDP-diacylglycerol (utilization significant compared to background, p: 0.05), microsomal fraction, 30°C, 20 min
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-
?
CDP-diacylglycerol + 1L-chiro-inositol
CMP + phosphatidyl-1L-chiro-inositol
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conversion of 25.1% CDP-diacylglycerol (non-significant), microsomal fraction, 30°C, 20 min
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-
?
CDP-diacylglycerol + D-chiro-inositol
CMP + phosphatidyl-chiro-inositol
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82% of the activity on myo-inositol
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-
?
CDP-diacylglycerol + L-chiro-inositol
CMP + phosphatidyl-chiro-inositol
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67% of the activity on myo-inositol
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-
?
CDP-diarachidonoylglycerol + myo-inositol
CMP + diarachidonoylphosphatidylinositol
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9% of the activity with CDP-1-stearoyl-2-oleoylglycerol
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r
CDP-didecanoyl-sn-glycerol + myo-inositol
CMP + didecanoylphosphatidylinositol
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preferred substrate
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r
CDP-diheptadecanoylglycerol + D-myo-inositol
CMP + 1,2-diheptadecanoyl-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-dilinoleoylglycerol + D-myo-inositol
CMP + 1,2-dilinoleoyl-phosphatidyl-1D-myo-inositol
CDP-dipalmitoylglycerol + D-myo-inositol
CMP + 1,2-dipalmitoyl-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-distearoylglycerol + myo-inositol
CMP + distearoylphosphatidylinositol
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38% of the activity with CDP-1-stearoyl-2-oleoylglycerol
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r
CDPdipalmitoyl-sn-glycerol + myo-inositol
CMP + dipalmitoylphosphatidylinositol
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70% of the activity with CDP-1-stearoyl-2-oleoylglycerol
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r
2-deoxy-CDP-diacylglycerol + myo-inositol
CMP + ?
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maximal activity only 36% of the optimal activity reached with CDP-diacylglycerol
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r
2-deoxy-CDP-diacylglycerol + myo-inositol
CMP + ?
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optimal activity is 25% higher then with CDP-diacylglycerol
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r
CDP-diacylglycerol + allo-inositol
CMP + phosphatidyl-allo-inositol
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83% of the activity on myo-inositol
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-
?
CDP-diacylglycerol + allo-inositol
CMP + phosphatidyl-allo-inositol
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conversion of 23.2% CDP-diacylglycerol (non-significant), microsomal fraction, 30°C, 20 min
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-
?
CDP-diacylglycerol + allo-inositol
CMP + phosphatidyl-allo-inositol
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83% of the activity on myo-inositol
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-
?
CDP-diacylglycerol + allo-inositol
CMP + phosphatidyl-allo-inositol
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conversion of 23.2% CDP-diacylglycerol (non-significant), microsomal fraction, 30°C, 20 min
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-
?
CDP-diacylglycerol + D-myo-inositol
CMP + phosphatidyl-1D-myo-inositol
key step in lipid biosynthesis
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-
?
CDP-diacylglycerol + D-myo-inositol
CMP + phosphatidyl-1D-myo-inositol
D-myo-inositol substrates: phosphatidylethanolamine, phosphatidic acid, overexpressed enzyme in bacterial membrane pellets, 30 min, 22°C, pH 8, 1% (v/v) Triton X-100, 20 mM MgCl2
fatty acid analysis by thin-layer chromatography
-
?
CDP-diacylglycerol + epi-inositol
CMP + phosphatidyl-epi-inositol
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62% of the activity on myo-inositol
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-
?
CDP-diacylglycerol + epi-inositol
CMP + phosphatidyl-epi-inositol
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conversion of 31.1% CDP-diacylglycerol (utilization significant compared to background, p: 0.01), microsomal fraction, 30°C, 20 min
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-
?
CDP-diacylglycerol + muco-inositol
CMP + phosphatidyl-muco-inositol
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41% of the activity on myo-inositol
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-
?
CDP-diacylglycerol + muco-inositol
CMP + phosphatidyl-muco-inositol
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conversion of 15.2% CDP-diacylglycerol (non-significant), microsomal fraction, 30°C, 20 min
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?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
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-
-
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?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
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specificity of PI synthase for the substrates, no activity with 1L-myo-inositol 1-phosphate
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-
?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
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-
-
?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
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-
-
?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
specificity of PI synthase for the substrates, no activity with 1L-myo-inositol 1-phosphate
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?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
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?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
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-
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?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
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?
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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enzyme plays a role in resynthesis of phosphatidylinositol during agonist-stimulated inositol-phospholipid metabolism
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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membrane lipid biosynthesis
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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key enzyme in cell membrane biosynthesis
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
-
?
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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formation of membrane phospholipids essential for the growth
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
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phosphatidylinositol synthase activity increased when zinc is depleted from the growth medium. Analysis of a zrt1DELTA zrt2DELTA mutant defective in plasma membrane zinc transport indicates that the cytoplasmic levels of zinc are responsible for the regulation of phosphatidylinositol synthase. Regulation of PIS1 gene expression by zinc depletion is mediated by the zinc-regulated transcription factor Zap1p. Direct in-teraction between glutathione S-transferase (GST)-Zap1p 687880 and a putative upstream activating sequence (UAS) zinc-responsive element in the PIS1
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-
?
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
high specificityfor myo-inositol
-
-
?
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol
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r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-myo-inositol
parasite membrane extracts, infected red blood cells
-
-
?
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-myo-inositol
-
myo-inositol and scyllo-inositol are preferred substrates
-
-
?
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-myo-inositol
-
conversion of 37.4% CDP-diacylglycerol (utilization significant compared to background, p: 0.01), microsomal fraction, standard reaction: 20 min, 30°C, pH 8, 2 mM MgCl2, 2 mM MnCl2, 1.6 mM Triton X-100
analyses by liquid scintillation counting and thin-layer chromatography
-
?
CDP-diacylglycerol + scyllo-inositol
CMP + phosphatidyl-scyllo-inositol
-
myo-inositol and scyllo-inositol are preferred substrates
-
-
?
CDP-diacylglycerol + scyllo-inositol
CMP + phosphatidyl-scyllo-inositol
-
conversion of 33.7% CDP-diacylglycerol (utilization significant compared to background, p: 0.01), microsomal fraction, 30°C, 20 min
-
-
?
CDP-dilinoleoylglycerol + D-myo-inositol
CMP + 1,2-dilinoleoyl-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-dilinoleoylglycerol + D-myo-inositol
CMP + 1,2-dilinoleoyl-phosphatidyl-1D-myo-inositol
highest activity, preferred in competition assay additionally containing 1,2-dipalmitoyl-, 1,2-dioleoyl-, and 1,2-diheptadecanoyl-CDP-diacylglycerol
-
-
?
CDP-dioleoylglycerol + D-myo-inositol
CMP + 1,2-dioleoyl-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-dioleoylglycerol + D-myo-inositol
CMP + 1,2-dioleoyl-phosphatidyl-1D-myo-inositol
highest activity, preferred in competition assay additionally containing 1,2-dipalmitoyl-, 1,2-dilinoleoyl-, and 1,2-diheptadecanoyl-CDP-diacylglycerol
-
-
?
CDP-dioleoylglycerol + myo-inositol
CMP + dioleoylphosphatidylinositol
-
-
-
r
CDP-dioleoylglycerol + myo-inositol
CMP + dioleoylphosphatidylinositol
-
-
-
r
CDP-dipalmitoyl-sn-glycerol + myo-inositol
CMP + dipalmitoylphosphatidylinositol
-
-
-
-
r
CDP-dipalmitoyl-sn-glycerol + myo-inositol
CMP + dipalmitoylphosphatidylinositol
-
-
-
-
?
additional information
?
-
-
enzyme also catalyzes diacylglycerol-independent exchange reaction between phosphatidylinositol and inositol
-
-
?
additional information
?
-
highly efficient conversion of biological mixture of CDP-diacylglycerol substrates (synthesised from phosphatidylethanolamine in plant leaves) into phosphatidyl-1D-myo-inositol mainly containing palmitic, acid linoleic acid and linolenic acid, complete conversion of CDP-diacylglycerol residues containing palmitic, acid linoleic acid and linolenic acid
-
-
?
additional information
?
-
highly efficient conversion of biological mixture of CDP-diacylglycerol substrates (synthesised from phosphatidylethanolamine in plant leaves) into phosphatidyl-1D-myo-inositol mainly containing palmitic, acid linoleic acid and linolenic acid, complete conversion of CDP-diacylglycerol residues containing palmitic, acid linoleic acid and linolenic acid
-
-
?
additional information
?
-
-
highly efficient conversion of biological mixture of CDP-diacylglycerol substrates (synthesised from phosphatidylethanolamine in plant leaves) into phosphatidyl-1D-myo-inositol mainly containing palmitic, acid linoleic acid and linolenic acid, complete conversion of CDP-diacylglycerol residues containing palmitic, acid linoleic acid and linolenic acid
-
-
?
additional information
?
-
in transgenic plants, elevated formation of phosphatidic acid, phosphatidylinositol, and polyphosphoinositide (PtdIns(4,5)P, PtdIns(4,5)P2) that are enriched in polyunsaturated fatty acids compared to wild-type plants
-
-
?
additional information
?
-
in transgenic plants, elevated formation of phosphatidic acid, phosphatidylinositol, and polyphosphoinositide (PtdIns(4,5)P, PtdIns(4,5)P2) that are enriched in polyunsaturated fatty acids compared to wild-type plants
-
-
?
additional information
?
-
-
in transgenic plants, elevated formation of phosphatidic acid, phosphatidylinositol, and polyphosphoinositide (PtdIns(4,5)P, PtdIns(4,5)P2) that are enriched in polyunsaturated fatty acids compared to wild-type plants
-
-
?
additional information
?
-
in transgenic plants, elevated formation of phosphatidic acid, phosphatidylinositol, phosphatidylethanolamine and diacylglycerol containing less polyunsaturated fatty acids but more saturated and monounsaturated fatty acids, no change in fatty acid composition of polyphopshoinositides compared to wild-type plants
-
-
?
additional information
?
-
in transgenic plants, elevated formation of phosphatidic acid, phosphatidylinositol, phosphatidylethanolamine and diacylglycerol containing less polyunsaturated fatty acids but more saturated and monounsaturated fatty acids, no change in fatty acid composition of polyphopshoinositides compared to wild-type plants
-
-
?
additional information
?
-
-
in transgenic plants, elevated formation of phosphatidic acid, phosphatidylinositol, phosphatidylethanolamine and diacylglycerol containing less polyunsaturated fatty acids but more saturated and monounsaturated fatty acids, no change in fatty acid composition of polyphopshoinositides compared to wild-type plants
-
-
?
additional information
?
-
moderate conversion of biological mixture of CDP-diacylglycerol substrates (synthesised from phosphatidylethanolamine in plant leaves) into phosphatidyl-1D-myo-inositol mainly containing palmitic acid and little linoleic acid, non-converted CDP-diacylglycerol residues containing linoleic acid and linolenic acid
-
-
?
additional information
?
-
moderate conversion of biological mixture of CDP-diacylglycerol substrates (synthesised from phosphatidylethanolamine in plant leaves) into phosphatidyl-1D-myo-inositol mainly containing palmitic acid and little linoleic acid, non-converted CDP-diacylglycerol residues containing linoleic acid and linolenic acid
-
-
?
additional information
?
-
-
moderate conversion of biological mixture of CDP-diacylglycerol substrates (synthesised from phosphatidylethanolamine in plant leaves) into phosphatidyl-1D-myo-inositol mainly containing palmitic acid and little linoleic acid, non-converted CDP-diacylglycerol residues containing linoleic acid and linolenic acid
-
-
?
additional information
?
-
preference of C18-fatty acid CDP-diacylglycerol substrates
-
-
?
additional information
?
-
preference of C18-fatty acid CDP-diacylglycerol substrates
-
-
?
additional information
?
-
-
preference of C18-fatty acid CDP-diacylglycerol substrates
-
-
?
additional information
?
-
preference of polyansaturated C18-fatty acid CDP-diacylglycerol substrates
-
-
?
additional information
?
-
preference of polyansaturated C18-fatty acid CDP-diacylglycerol substrates
-
-
?
additional information
?
-
-
preference of polyansaturated C18-fatty acid CDP-diacylglycerol substrates
-
-
?
additional information
?
-
-
enzyme also catalyzes diacylglycerol-independent exchange reaction between phosphatidylinositol and inositol
-
-
?
additional information
?
-
-
UDP-diacylglycerol, ADP-diacylglycerol, and GDP-diacylglycerol are inactive as substrates
-
-
?
additional information
?
-
-
CDP, CTP, UMP, AMP, and GMP, are no substrates
-
-
?
additional information
?
-
partial complementation of PIS activity by overexpression of PfPIS/ScPIS hybrids in ScPIS1-deficient Saccharomyces cerevisiae mutant strain BY4743, analysis by enzyme assay (30°C, yeast membrane pellet, in presence of 18 mM octyl-beta-D-glucopyranoside) or lipid incorporation and extraction
-
-
?
additional information
?
-
partial complementation of PIS activity by overexpression of PfPIS/ScPIS hybrids in ScPIS1-deficient Saccharomyces cerevisiae mutant strain BY4743, analysis by enzyme assay (30°C, yeast membrane pellet, in presence of 18 mM octyl-beta-D-glucopyranoside) or lipid incorporation and extraction
-
-
?
additional information
?
-
-
partial complementation of PIS activity by overexpression of PfPIS/ScPIS hybrids in ScPIS1-deficient Saccharomyces cerevisiae mutant strain BY4743, analysis by enzyme assay (30°C, yeast membrane pellet, in presence of 18 mM octyl-beta-D-glucopyranoside) or lipid incorporation and extraction
-
-
?
additional information
?
-
-
enzyme also catalyzes diacylglycerol-independent exchange reaction between phosphatidylinositol and inositol
-
-
?
additional information
?
-
-
enzyme also catalyzes diacylglycerol-independent exchange reaction between phosphatidylinositol and inositol
-
-
?
additional information
?
-
cytosolically made inositol and CDP-diacylglycerol can access the active site of the yeast PI synthase Pis1 from the cytosolic side
-
-
?
additional information
?
-
-
cytosolically made inositol and CDP-diacylglycerol can access the active site of the yeast PI synthase Pis1 from the cytosolic side
-
-
?
additional information
?
-
cytosolically made inositol and CDP-diacylglycerol can access the active site of the yeast PI synthase Pis1 from the cytosolic side
-
-
?
additional information
?
-
-
formation of novel non-myo-inositol-containing second messengers, preferred non-myo-inositols are scyllo- and chiro-inositol
-
-
?
additional information
?
-
-
microsomal fraction contains additional PdtIn: inositol phosphatidyl transferase activity (inositol headgroup exchange, 20 min, 30°C) between myo-, scyllo-, 1D-chiro-inositol and phosphatidyl-myo-inositol, increased in presence of CMP, least specificity for 1L-chiro- and muco-inositol
-
-
?
additional information
?
-
-
myo- and scyllo-inositol preferred inositol isomers for PtdIn synthase activity, least specificity for muco-inositol
-
-
?
additional information
?
-
-
formation of novel non-myo-inositol-containing second messengers, preferred non-myo-inositols are scyllo- and chiro-inositol
-
-
?
additional information
?
-
-
microsomal fraction contains additional PdtIn: inositol phosphatidyl transferase activity (inositol headgroup exchange, 20 min, 30°C) between myo-, scyllo-, 1D-chiro-inositol and phosphatidyl-myo-inositol, increased in presence of CMP, least specificity for 1L-chiro- and muco-inositol
-
-
?
additional information
?
-
-
myo- and scyllo-inositol preferred inositol isomers for PtdIn synthase activity, least specificity for muco-inositol
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CDP-diacylglycerol + D-myo-inositol
CMP + phosphatidyl-1D-myo-inositol
key step in lipid biosynthesis
-
-
?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
-
?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-diacylglycerol + myo-inositol
CMP + 1-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r