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Information on EC 2.7.8.27 - sphingomyelin synthase

for references in articles please use BRENDA:EC2.7.8.27
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IUBMB Comments
The reaction can occur in both directions . This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism . Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types . Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
PC:ceramide cholinephosphotransferase, PC:ceramide phosphocholinetransferase, phosphatidylcholine:ceramide cholinephosphotransferase 1, phosphatidylcholine:ceramide cholinephosphotransferase 2, PlcH, SGMS, SGMS1, Sgms2, SM synthase, SM synthase 1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
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