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Literature summary for 2.7.8.27 extracted from

  • Zhang, P.; Hua, L.; Hou, H.; Du, X.; He, Z.; Liu, M.; Hu, X.; Yan, N.
    Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/beta-catenin signaling pathway (2018), Int. J. Mol. Med., 42, 3344-3354 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NHU3
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Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function SGMS2 overexpression may promote endothelial cell dysfunction by activating the Wnt/beta-catenin signaling pathway. SGMS2 overexpression promotes apoptosis and macrophage adhesion of H2O2-induced endothelial cells, thereby increasing the expression of beta-catenin. SGMS inhibitor Dy105 may inhibit the evolution of oxidative stress-induced dysfunction Homo sapiens