EC Number   |
Natural Substrates |
|---|
   2.7.8.27 | 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)-sphingosine + 1,2-dimyristoyl-sn-glycero-3-phosphocholine |
- |
| 2.7.8.27 | a ceramide + a phosphatidylcholine |
- |
| 2.7.8.27 | ceramide + phosphatidylcholine |
- |
| 2.7.8.27 | ceramide + phosphatidylcholine |
the enzyme restores homeostasis between sphingomyelin and ceramide pools |
| 2.7.8.27 | more |
SMS1 not only suppresses the effects of Bax overexpression, but it also blocks the deleterious effects of a number of other stresses, including hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. Sphingomyelin synthase 1 likely prevents cell death by counteracting stress-mediated accumulation of endogenous sphingolipids |
| 2.7.8.27 | more |
SMS2 may play a crucial role in the lipid metabolism in arosome formation and the plasma membrane restructuring from late round spermatids to early elongating spermatids |
| 2.7.8.27 | more |
synthesis of N-6[7-nitro-2,1,3-benzoxadiazol-4-yl]aminohexanoyl-phosphatidylcholine on the basolateral cell surface of MDCK cells occurs via the reverse reaction of a sphingomyelin synthase |
| 2.7.8.27 | more |
both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells, sphingomyelin synthesis plays a critical role in cell growth and survival, overview |
| 2.7.8.27 | more |
membrane sphingomyelin is a key component of lipid rafts involved in TCR signal transduction, physiological functions of sphingomyelin, overview |
| 2.7.8.27 | more |
SMS1 converts de novo ceramide into sphingomyelin, overview |
