Literature summary for 2.7.8.27 extracted from

Wittmann, A.; Grimm, M.O.; Scherthan, H.; Horsch, M.; Beckers, J.; Fuchs, H.; Gailus-Durner, V.; Hrabe de Angelis, M.; Ford, S.J.; Burton, N.C.; Razansky, D.; Truembach, D.; Aichler, M.; Walch, A.K.; Calzada-Wack, J.; Neff, F.; Wurst, W.; Hartmann, T.; Floss, T.
Sphingomyelin synthase 1 is essential for male fertility in mice (2016), PLoS ONE, 11, e0164298 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8VCQ6	isoform SGMS1	-

Synonyms

Synonyms	Comment	Organism
SGMS1	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	Sms1-/- mice show a spermatogenesis defect, characterized by sloughing of spermatocytes and spermatids, causing progressive infertility of male homozygotes. A reduction in several long chain unsaturated phosphatidylcholins, lysophosphatidylcholins and sphingolipids is observed in the testes of mutants, together with blood-testis barrier dysfunction. A supplementary diet of the essential omega-3 docosahexaenoic acid and eicosapentaenoic acid diminishes germ cell sloughing from the seminiferous epithelium and restores spermatogenesis and fertility in 50% of previously infertile mutants	Mus musculus

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Release 2023.1 (January 2023)