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Literature summary for 2.7.8.27 extracted from

  • Burns, T.A.; Subathra, M.; Signorelli, P.; Choi, Y.; Yang, X.; Wang, Y.; Villani, M.; Bhalla, K.; Zhou, D.; Luberto, C.
    Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene (2013), J. Lipid Res., 54, 794-805.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.27

Inhibitors

Inhibitors Comment Organism Structure
D609
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
chronic myeloid leukemia cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + ceramide
-
 Homo sapiens sphingomyelin + 1,2-diacyl-sn-glycerol
-
 ?

Synonyms

Synonyms Comment Organism
SMS1
-
 Homo sapiens
sphingomyelin synthase 1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme inhibition or down-regulation of SMS1 expression by siRNA selectively inhibits the proliferation of Bcr-abl-positive cells down
Homo sapiens isoform SMS1 is highly elevated (approximately 10fold) in K-562 chronic myelogenous leukemia cells up

General Information

General Information Comment Organism
physiological function the Sms1 gene is a downstream target of Bcr-abl, involved in sustaining cell proliferation of Bcr-abl-positive cells Homo sapiens