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EC Number	Localization	Commentary	GeneOntology No.	Reference
2.7.8.27	acrosome	SMS2 associates with the developing acrosome beginning in late round spermatids through elongating spermatids. SMS2 may play a crucial role in the arosome formation	-	669649
2.7.8.27	cell membrane	-	-	669649
2.7.8.27	chromatin	-	GO:0000785 AmiGO QuickGO	668582
2.7.8.27	chromatin	high activity. The presence of sphingomyelin synthase in chromatin may have a relevant influence in regulating the diacylglycerol/ceramide ratio at this particular subcellular level	GO:0000785 AmiGO QuickGO	668587
2.7.8.27	cytoplasm	-	GO:0005737 AmiGO QuickGO	723168
2.7.8.27	cytosol	low activity	GO:0005829 AmiGO QuickGO	668587
2.7.8.27	Golgi apparatus	-	GO:0005794 AmiGO QuickGO	668400, 738936
2.7.8.27	Golgi apparatus	isoform SMS1	GO:0005794 AmiGO QuickGO	721500, 723307
2.7.8.27	Golgi apparatus	isoform SMS1 and SMS2	GO:0005794 AmiGO QuickGO	723537
2.7.8.27	Golgi apparatus	isoform SMS2	GO:0005794 AmiGO QuickGO	723307

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Release 2023.1 (January 2023)