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Literature summary for 2.7.8.27 extracted from

  • Kidani, Y.; Ohshima, K.; Sakai, H.; Kohno, T.; Baba, A.; Hattori, M.
    Differential localization of sphingomyelin synthase isoforms in neurons regulates sphingomyelin cluster formation (2012), Biochem. Biophys. Res. Commun., 417, 1014-1017.
    View publication on PubMed
Search for more literature for 2.7.8.27

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus isoform SMS1 Mus musculus 5794
-
plasma membrane isoform SMS2 Mus musculus 5886
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Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebellum in cerebellum, isoform SMS1 is barely detectable both in granule and Purkinje cells while SMS2 is markedly expressed in Purkinje cells and inner granule cells Mus musculus
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hippocampus in hippocampus, both isoforms SMS1 and SMS2 are expressed in granule cells while SMS2 expression is stronger in dentate gyrus Mus musculus
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neuron only isoform SMS2 proteins localize in neurites of hippocampal neurons Mus musculus
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Synonyms

Synonyms Comment Organism
SM synthase
-
 Mus musculus
SMS1 isoform Mus musculus
SMS2 isoform Mus musculus

General Information

General Information Comment Organism
physiological function isoform SMS2, rather than isoform SMS1, is the major enzyme that is important for sphingomyelin synthesis in the long neurites and the growth cone Mus musculus