Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-((2,5-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((2,5-dimethoxybenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((2,6-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((2,6-dimethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((2-((5-chloropentyl)oxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((2-((6-chlorohexyl)oxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((2-(4-chlorobutoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((2-chloro-5-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((2-chloro-6-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((2-chlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((2-ethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide | selectivity ratio is more than 1400fold for purified isoform SGMS2 over SGMS1. The compound dose-dependently diminishes apoB secretion from Huh7 cells, and significantly reduces the SGMS activity and increases cholesterol efflux from macrophages. It inhibits the secretion of LPS-mediated pro-inflammatory cytokine and chemokine in macrophages. In C57BL/6J mice, the compound is orally efficacious. | Homo sapiens | |
2-((2-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((3-chloro-2-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((3-chloro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((3-chlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((3-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((5-chloro-2-(2-methoxyethoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((5-chloro-2-(3-methoxypropoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((5-chloro-2-(heptyloxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((5-chloro-2-(hexyloxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((5-chloro-2-methoxybenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((5-chloro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-((5-fluoro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-(benzyloxy)-N-(pyridin-2-yl)benzamide | - |
Homo sapiens | |
2-(benzyloxy)-N-(pyridin-3-yl)benzamide | - |
Homo sapiens | |
2-[2-[(2-methylphenyl)methoxy]phenyl][1,3]oxazolo[5,4-b]pyridine | - |
Homo sapiens | |
N-(pyridin-3-yl)-2-((2-(trifluoromethyl)benzyl)oxy)benzamide | - |
Homo sapiens | |
N-[(4-bromophenyl)methyl]-2-[4-[(2-phenylethyl)sulfamoyl]phenoxy]acetamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8NHU3 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
Sgms2 | - |
Homo sapiens |
SMS2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00043 | - |
pH 7.4, 37°C | Homo sapiens | 2-((5-chloro-2-(heptyloxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.00047 | - |
pH 7.4, 37°C | Homo sapiens | 2-((2-((6-chlorohexyl)oxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.00052 | - |
pH 7.4, 37°C | Homo sapiens | 2-((5-chloro-2-(hexyloxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.00067 | - |
pH 7.4, 37°C | Homo sapiens | 2-((2-((5-chloropentyl)oxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.00067 | - |
pH 7.4, 37°C | Homo sapiens | 2-((5-chloro-2-methoxybenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.00069 | - |
pH 7.4, 37°C | Homo sapiens | 2-((2,6-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.00074 | - |
pH 7.4, 37°C | Homo sapiens | 2-((2-chloro-5-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.00074 | - |
pH 7.4, 37°C | Homo sapiens | 2-((5-fluoro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.00088 | - |
pH 7.4, 37°C | Homo sapiens | 2-((2-ethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.00089 | - |
pH 7.4, 37°C | Homo sapiens | 2-((2,6-dimethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.00099 | - |
pH 7.4, 37°C | Homo sapiens | 2-((2,5-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0011 | - |
pH 7.4, 37°C | Homo sapiens | 2-((2-chlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0011 | - |
pH 7.4, 37°C | Homo sapiens | 2-((5-chloro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0013 | - |
pH 7.4, 37°C | Homo sapiens | 2-((2-(4-chlorobutoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0014 | - |
pH 7.4, 37°C | Homo sapiens | 2-((3-chlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0015 | - |
pH 7.4, 37°C | Homo sapiens | 2-((2-chloro-6-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0015 | - |
pH 7.4, 37°C | Homo sapiens | 2-((2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0016 | - |
pH 7.4, 37°C | Homo sapiens | 2-((3-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0017 | - |
pH 7.4, 37°C | Homo sapiens | 2-[2-[(2-methylphenyl)methoxy]phenyl][1,3]oxazolo[5,4-b]pyridine | |
0.0021 | - |
pH 7.4, 37°C | Homo sapiens | N-(pyridin-3-yl)-2-((2-(trifluoromethyl)benzyl)oxy)benzamide | |
0.0021 | - |
pH 7.4, 37°C | Homo sapiens | N-[(4-bromophenyl)methyl]-2-[4-[(2-phenylethyl)sulfamoyl]phenoxy]acetamide | |
0.0028 | - |
pH 7.4, 37°C | Homo sapiens | 2-((2,5-dimethoxybenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0031 | - |
pH 7.4, 37°C | Homo sapiens | 2-((3-chloro-2-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0032 | - |
pH 7.4, 37°C | Homo sapiens | 2-(benzyloxy)-N-(pyridin-3-yl)benzamide | |
0.0035 | - |
pH 7.4, 37°C | Homo sapiens | 2-((2-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0038 | - |
pH 7.4, 37°C | Homo sapiens | 2-((3-chloro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0041 | - |
pH 7.4, 37°C | Homo sapiens | 2-((5-chloro-2-(3-methoxypropoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0116 | - |
pH 7.4, 37°C | Homo sapiens | 2-((5-chloro-2-(2-methoxyethoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide | |
0.0117 | - |
pH 7.4, 37°C | Homo sapiens | 2-(benzyloxy)-N-(pyridin-2-yl)benzamide |