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Literature summary for 2.7.8.27 extracted from

  • Li, Y.; Huang, T.; Lou, B.; Ye, D.; Qi, X.; Li, X.; Hu, S.; Ding, T.; Chen, Y.; Cao, Y.; Mo, M.; Dong, J.; Wei, M.; Chu, Y.; Li, H.; Jiang, X.; Cheng, N.; Zhou, L.
    Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor (2019), Eur. J. Med. Chem., 163, 864-882 .
    View publication on PubMed
Search for more literature for 2.7.8.27

Inhibitors

Inhibitors Comment Organism Structure
2-((2,5-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((2,5-dimethoxybenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((2,6-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((2,6-dimethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((2-((5-chloropentyl)oxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((2-((6-chlorohexyl)oxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((2-(4-chlorobutoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((2-chloro-5-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((2-chloro-6-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((2-chlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((2-ethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide selectivity ratio is more than 1400fold for purified isoform SGMS2 over SGMS1. The compound dose-dependently diminishes apoB secretion from Huh7 cells, and significantly reduces the SGMS activity and increases cholesterol efflux from macrophages. It inhibits the secretion of LPS-mediated pro-inflammatory cytokine and chemokine in macrophages. In C57BL/6J mice, the compound is orally efficacious. Homo sapiens
2-((2-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((3-chloro-2-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((3-chloro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((3-chlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((3-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((5-chloro-2-(2-methoxyethoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((5-chloro-2-(3-methoxypropoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((5-chloro-2-(heptyloxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((5-chloro-2-(hexyloxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((5-chloro-2-methoxybenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((5-chloro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-((5-fluoro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-(benzyloxy)-N-(pyridin-2-yl)benzamide
-
 Homo sapiens
2-(benzyloxy)-N-(pyridin-3-yl)benzamide
-
 Homo sapiens
2-[2-[(2-methylphenyl)methoxy]phenyl][1,3]oxazolo[5,4-b]pyridine
-
 Homo sapiens
N-(pyridin-3-yl)-2-((2-(trifluoromethyl)benzyl)oxy)benzamide
-
 Homo sapiens
N-[(4-bromophenyl)methyl]-2-[4-[(2-phenylethyl)sulfamoyl]phenoxy]acetamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NHU3
-
-

Synonyms

Synonyms Comment Organism
Sgms2
-
 Homo sapiens
SMS2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00043
-
 pH 7.4, 37°C Homo sapiens 2-((5-chloro-2-(heptyloxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
0.00047
-
 pH 7.4, 37°C Homo sapiens 2-((2-((6-chlorohexyl)oxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
0.00052
-
 pH 7.4, 37°C Homo sapiens 2-((5-chloro-2-(hexyloxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
0.00067
-
 pH 7.4, 37°C Homo sapiens 2-((2-((5-chloropentyl)oxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
0.00067
-
 pH 7.4, 37°C Homo sapiens 2-((5-chloro-2-methoxybenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.00069
-
 pH 7.4, 37°C Homo sapiens 2-((2,6-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.00074
-
 pH 7.4, 37°C Homo sapiens 2-((2-chloro-5-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.00074
-
 pH 7.4, 37°C Homo sapiens 2-((5-fluoro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.00088
-
 pH 7.4, 37°C Homo sapiens 2-((2-ethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.00089
-
 pH 7.4, 37°C Homo sapiens 2-((2,6-dimethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.00099
-
 pH 7.4, 37°C Homo sapiens 2-((2,5-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0011
-
 pH 7.4, 37°C Homo sapiens 2-((2-chlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0011
-
 pH 7.4, 37°C Homo sapiens 2-((5-chloro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0013
-
 pH 7.4, 37°C Homo sapiens 2-((2-(4-chlorobutoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0014
-
 pH 7.4, 37°C Homo sapiens 2-((3-chlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0015
-
 pH 7.4, 37°C Homo sapiens 2-((2-chloro-6-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0015
-
 pH 7.4, 37°C Homo sapiens 2-((2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0016
-
 pH 7.4, 37°C Homo sapiens 2-((3-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0017
-
 pH 7.4, 37°C Homo sapiens 2-[2-[(2-methylphenyl)methoxy]phenyl][1,3]oxazolo[5,4-b]pyridine
0.0021
-
 pH 7.4, 37°C Homo sapiens N-(pyridin-3-yl)-2-((2-(trifluoromethyl)benzyl)oxy)benzamide
0.0021
-
 pH 7.4, 37°C Homo sapiens N-[(4-bromophenyl)methyl]-2-[4-[(2-phenylethyl)sulfamoyl]phenoxy]acetamide
0.0028
-
 pH 7.4, 37°C Homo sapiens 2-((2,5-dimethoxybenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0031
-
 pH 7.4, 37°C Homo sapiens 2-((3-chloro-2-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0032
-
 pH 7.4, 37°C Homo sapiens 2-(benzyloxy)-N-(pyridin-3-yl)benzamide
0.0035
-
 pH 7.4, 37°C Homo sapiens 2-((2-fluorobenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0038
-
 pH 7.4, 37°C Homo sapiens 2-((3-chloro-2-methylbenzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0041
-
 pH 7.4, 37°C Homo sapiens 2-((5-chloro-2-(3-methoxypropoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0116
-
 pH 7.4, 37°C Homo sapiens 2-((5-chloro-2-(2-methoxyethoxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide
0.0117
-
 pH 7.4, 37°C Homo sapiens 2-(benzyloxy)-N-(pyridin-2-yl)benzamide