Literature summary for 2.7.8.27 extracted from

Li, X.; Luo, T.; Li, H.; Yan, N.
Sphingomyelin synthase 2 participate in the regulation of sperm motility and apoptosis (2020), Molecules, 25, 4231 .

Search for more literature for 2.7.8.27

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8NHU3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
semen	SMS2 mRNA levels are decreased by about 80.67, and protein levels are reduced to approximately 71.33 % in asthenospermia compared to normozoospermia	Homo sapiens	-
testis	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	inhibition of SMS2 activity decreases sperm motility and penetration ability into methylcellulose, but has no influence on capacitation and acrosome reaction, or on intracellular Ca2+ concentration compared to IgG-treated control groups. The phosphorylation level of Akt is decreased, whereas the phosphorylation of ERK and cleaved-caspase 3 levels are significantly increased by SGMS2 inhibition	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)