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Literature summary for 2.7.8.27 extracted from

  • Huang, T.; Li, X.; Hu, S.; Zhao, B.; Chen, P.; Liu, X.; Ye, D.; Cheng, N.
    Analysis of fluorescent ceramide and sphingomyelin analogs: a novel approach for in vivo monitoring of sphingomyelin synthase activity (2014), Lipids, 49, 1071-1079.
    View publication on PubMed
Search for more literature for 2.7.8.27

Application

Application Comment Organism
medicine SMS inhibitors might be useful for the treatment of atherosclerosis or coronary artery disease Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile i.e. D2, development of a HPLC-FLD method for real-time monitoring of relative SMS activity based on the measurement of C6-NBD-Cer and C6-NBDCerPCho in plasma, which is then used to assess the SMS inhibitory activity of D2 in vivo, overview Mus musculus
tricyclodecan-9-yl-xanthogenate i.e. D609 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a ceramide + a phosphatidylcholine Mus musculus
-
 a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9D4B1 SMS2
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Mus musculus
-
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a ceramide + a phosphatidylcholine
-
 Mus musculus a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
 ?
additional information development of a HPLC-FLD method for real-time monitoring of relative SMS activity based on the measurement of 6-((N-(7-nitrobenz-2-oxa-1.3-diazol-4-yl)amino)hexanoyl)-sphingosine (C6-NBD-Cer) and 6-((N-(7-nitro-2-1,3-benzoxadiazol-4-yl)amino)hexanoyl)-sphingosine-1-phosphocholine (C6-NBDCerPCho) in plasma, which is then used to assess the SMS inhibitory activity of D2 in vivo, kinetics, overview Mus musculus ?
-
 ?
N-(6-((7-nitrobenz-2-oxa-1.3-diazol-4-yl)amino)hexanoyl)-sphingosine + a phosphatidylcholine i.e. C6-NBD-ceramide Mus musculus N-(6-((7-nitro-2-1,3-benzoxadiazol-4-yl)amino)hexanoyl)-sphingosine-1-phosphocholine + a 1,2-diacyl-sn-glycerol i.e. C6-NBD-sphingomyelin or C6-NBDCerPCho ?

Synonyms

Synonyms Comment Organism
SMS
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0135
-
 SMS2, pH and temperature not specified in the publication Mus musculus 2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile
0.0245
-
 SMS in liver homogenate, pH and temperature not specified in the publication Mus musculus 2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile
0.4027
-
 pH and temperature not specified in the publication Mus musculus tricyclodecan-9-yl-xanthogenate

General Information

General Information Comment Organism
metabolism sphingomyelin synthase (SMS) is the last key enzyme in the sphingosine-1-phosphocholine synthesis process Mus musculus