Reference on EC 2.7.8.27 - sphingomyelin synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vivekananda, J.; Smith, D.; King, R.J.
Sphingomyelin metabolites inhibit sphingomyelin synthase and CTP:phosphocholine cytidylyltransferase
Am. J. Physiol.
281
L98-L107
2001
Homo sapiens
Albi, E.; La Porta, C.A.; Cataldi, S.; Magni, M.V.
Nuclear sphingomyelin-synthase and protein kinase C delta in melanoma cells
Arch. Biochem. Biophys.
438
156-161
2005
Homo sapiens, Mus musculus
Hanada, K.; Horii, M.; Akamatsu, Y.
Functional reconstitution of sphingomyelin synthase in Chinese hamster ovary cell membranes
Biochim. Biophys. Acta
1086
151-156
1991
Cricetulus griseus
Allan, D.; Obradors, M.J.
Enzyme distributions in subcellular fractions of BHK cells infected with Semliki forest virus: evidence for a major fraction of sphingomyelin synthase in the trans-Golgi network
Biochim. Biophys. Acta
1450
277-287
1999
Mesocricetus auratus
Miro-Obradors, M.J.; Osada, J.; Aylagas, H.; Sanchez-Vegazo, I.; Palacios-Alaiz, E.
Microsomal sphingomyelin accumulation in thioacetamide-injured regenerating rat liver: involvement of sphingomyelin synthase activity
Carcinogenesis
14
941-946
1993
Rattus norvegicus
Huitema, K.; van den Dikkenberg, J.; Brouwers, J.F.H.M.; Holthuis, J.C.M.
Identification of a family of animal sphingomyelin synthases
EMBO J.
23
33-44
2004
Caenorhabditis elegans (Q20735), Caenorhabditis elegans (Q9U3D4), Caenorhabditis elegans, Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3), Homo sapiens, Mus musculus (Q8VCQ6), Mus musculus
Meng, A.; Luberto, C.; Meier, P.; Bai, A.; Yang, X.; Hannun, Y.A.; Zhou, D.
Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells
Exp. Cell Res.
292
385-392
2004
Homo sapiens
Albi, E.; Magni, M.V.
Sphingomyelin synthase in rat liver nuclear membrane and chromatin
FEBS Lett.
460
369-372
1999
Rattus norvegicus
Albi, E.; Lazzarini, R.; Magni, M.V.
Reverse sphingomyelin-synthase in rat liver chromatin
FEBS Lett.
549
152-156
2003
Rattus norvegicus
Yang, Z.; Khoury, C.; Jean-Baptiste, G.; Greenwood, M.T.
Identification of mouse sphingomyelin synthase 1 as a suppressor of Bax-mediated cell death in yeast
FEMS Yeast Res.
6
751-762
2006
Mus musculus (Q8VCQ6), Mus musculus
Guillen, N.; Navarro, M.A.; Surra, J.C.; Arnal, C.; Fernandez-Juan, M.; Cebrian-Perez, J.A.; Osada, J.
Cloning, characterization, expression and comparative analysis of pig Golgi membrane sphingomyelin synthase 1
Gene
388
117-124
2007
Sus scrofa (A0AAS4), Sus scrofa
van Helvoort, A.; van't Hof, W.; Ritsema, T.; Sandra, A.; van Meer, G.
Conversion of diacylglycerol to phosphatidylcholine on the basolateral surface of epithelial (Madin-Darby canine kidney) cells. Evidence for the reverse action of a sphingomyelin synthase
J. Biol. Chem.
269
1763-1769
1994
Canis lupus familiaris
Luberto, C.; Hannun, Y.A.
Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?
J. Biol. Chem.
273
14550-14559
1998
Homo sapiens
Luberto, C.; Stonehouse, M.J.; Collins, E.A.; Marchesini, N.; El-Bawab, S.; Vasil, A.I.; Vasil, M.L.; Hannun, Y.A.
Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme
J. Biol. Chem.
278
32733-32743
2003
Pseudomonas aeruginosa
Yamaoka, S.; Miyaji, M.; Kitano, T.; Umehara, H.; Okazaki, T.
Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells
J. Biol. Chem.
279
18688-18693
2004
Homo sapiens (Q86VZ5), Homo sapiens
Tafesse, F.G.; Ternes, P.; Holthuis, J.C.
The multigenic sphingomyelin synthase family
J. Biol. Chem.
281
29421-29425
2006
Mus musculus, Pseudomonas aeruginosa, Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3)
Elmendorf, H.G.; Haldar, K.
Plasmodium falciparum exports the Golgi marker sphingomyelin synthase into a tubovesicular network in the cytoplasm of mature erythrocytes
J. Cell Biol.
124
449-462
1994
Plasmodium falciparum
Lee, N.P.; Mruk, D.D.; Xia, W.; Cheng, C.Y.
Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes
J. Endocrinol.
192
17-32
2007
Rattus norvegicus, Rattus norvegicus (Q4JM44)
Dong, J.; Liu, J.; Lou, B.; Li, Z.; Ye, X.; Wu, M.; Jiang, X.C.
Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice
J. Lipid Res.
47
1307-1314
2006
Mus musculus (Q8VCQ6), Mus musculus (Q9D4B1), Mus musculus
Hailemariam, T.K.; Huan, C.; Liu, J.; Li, Z.; Roman, C.; Kalbfeisch, M.; Bui, H.H.; Peake, D.A.; Kuo, M.; Cao, G.; Wadgaonkar, R.; Jiang, X.
Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation
Arterioscler. Thromb. Vasc. Biol.
28
1519-1526
2008
Homo sapiens, Mus musculus
Separovic, D.; Hanada, K.; Maitah, M.Y.; Nagy, B.; Hang, I.; Tainsky, M.A.; Kraniak, J.M.; Bielawski, J.
Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage
Biochem. Biophys. Res. Commun.
358
196-202
2007
Homo sapiens
Van der luit, A.H.; Budde, M.; Zerp, S.; Caan, W.; Klarenbeek, J.B.; Verheij, M.; van Blitterswijk, W.J.
Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts
Biochem. J.
401
541-549
2007
Mus musculus
Villani, M.; Subathra, M.; Im, Y.B.; Choi, Y.; Signorelli, P.; Del Poeta, M.; Luberto, C.
Sphingomyelin synthases regulate production of diacylglycerol at the Golgi
Biochem. J.
414
31-41
2008
Homo sapiens
Li, Z.; Hailemariam, T.K.; Zhou, H.; Li, Y.; Duckworth, D.C.; Peake, D.A.; Zhang, Y.; Kuo, M.S.; Cao, G.; Jiang, X.C.
Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization
Biochim. Biophys. Acta
1771
1186-1194
2007
Homo sapiens
Yeang, C.; Varshney, S.; Wang, R.; Zhang, Y.; Ye, D.; Jiang, X.C.
The domain responsible for sphingomyelin synthase (SMS) activity
Biochim. Biophys. Acta
1781
610-617
2008
Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3)
Dmitrieva, V.G.; Torshina, E.V.; Yuzhakov, V.V.; Povarova, O.V.; Skvortsova, V.I.; Limborska, S.A.; Dergunova, L.V.
Expression of sphingomyelin synthase 1 gene in rat brain focal ischemia
Brain Res.
1188
222-227
2008
Rattus norvegicus
Separovic, D.; Semaan, L.; Tarca, A.L.; Awad Maitah, M.Y.; Hanada, K.; Bielawski, J.; Villani, M.; Luberto, C.
Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage
Exp. Cell Res.
314
1860-1868
2008
Homo sapiens
Jin, Z.X.; Huang, C.R.; Dong, L.; Goda, S.; Kawanami, T.; Sawaki, T.; Sakai, T.; Tong, X.P.; Masaki, Y.; Fukushima, T.; Tanaka, M.; Mimori, T.; Tojo, H.; Bloom, E.T.; Okazaki, T.; Umehara, H.
Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells
Int. Immunol.
20
1427-1437
2008
Homo sapiens
Tafesse, F.G.; Huitema, K.; Hermansson, M.; van der Poel, S.; van den Dikkenberg, J.; Uphoff, A.; Somerharju, P.; Holthuis, J.C.
Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells
J. Biol. Chem.
282
17537-17547
2007
Homo sapiens, Mus musculus
Liu, J.; Zhang, H.; Li, Z.; Hailemariam, T.K.; Chakraborty, M.; Jiang, K.; Qiu, D.; Bui, H.H.; Peake, D.A.; Kuo, M.S.; Wadgaonkar, R.; Cao, G.; Jiang, X.C.
Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice
Arterioscler. Thromb. Vasc. Biol.
29
850-856
2009
Mus musculus
Tani, M.; Kuge, O.
Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membranes
Biochem. Biophys. Res. Commun.
381
328-332
2009
Homo sapiens
Liu, J.; Huan, C.; Chakraborty, M.; Zhang, H.; Lu, D.; Kuo, M.S.; Cao, G.; Jiang, X.C.
Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice
Circ. Res.
105
295-303
2009
Mus musculus
Vacaru, A.M.; Tafesse, F.G.; Ternes, P.; Kondylis, V.; Hermansson, M.; Brouwers, J.F.; Somerharju, P.; Rabouille, C.; Holthuis, J.C.
Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER
J. Cell Biol.
185
1013-1027
2009
Homo sapiens
Ding, T.; Li, Z.; Hailemariam, T.; Mukherjee, S.; Maxfield, F.; Wu, M.; Jiang, X.
SMS overexpression and knockdown: Impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis
J. Lipid Res.
49
376-385
2008
Homo sapiens
Ternes, P.; Brouwers, J.F.; van den Dikkenberg, J.; Holthuis, J.C.
Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase
J. Lipid Res.
50
2270-2277
2009
Homo sapiens
Chen, Y.; Yurek, D.A.; Yu, L.; Wang, H.; Ehsani, M.E.; Qian, Y.W.; Konrad, R.J.; Jiang, X.C.; Kuo, M.S.; Cao, G.; Wang, J.
Development of a quantitative biochemical and cellular sphingomyelin synthase assay using mass spectrometry
Anal. Biochem.
438
61-66
2013
Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3), Homo sapiens
Kidani, Y.; Ohshima, K.; Sakai, H.; Kohno, T.; Baba, A.; Hattori, M.
Differential localization of sphingomyelin synthase isoforms in neurons regulates sphingomyelin cluster formation
Biochem. Biophys. Res. Commun.
417
1014-1017
2012
Mus musculus
Burns, T.A.; Subathra, M.; Signorelli, P.; Choi, Y.; Yang, X.; Wang, Y.; Villani, M.; Bhalla, K.; Zhou, D.; Luberto, C.
Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene
J. Lipid Res.
54
794-805
2013
Homo sapiens
Zhao, Y.R.; Dong, J.B.; Li, Y.; Wu, M.P.
Sphingomyelin synthase 2 over-expression induces expression of aortic inflammatory biomarkers and decreases circulating EPCs in ApoE KO mice
Life Sci.
90
867-873
2012
Homo sapiens
Man, C.; Lee, J.
Molecular cloning, sequence characterization, and tissue expression analysis of chicken sphingomyelin synthase 1 (SMS1)
Mol. Cell. Biochem.
357
353-361
2011
Gallus gallus (Q7T3T4), Gallus gallus
Asano, S.; Kitatani, K.; Taniguchi, M.; Hashimoto, M.; Zama, K.; Mitsutake, S.; Igarashi, Y.; Takeya, H.; Kigawa, J.; Hayashi, A.; Umehara, H.; Okazaki, T.
Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway
Mol. Cell. Biol.
32
3242-3252
2012
Mus musculus
Yeang, C.; Ding, T.; Chirico, W.J.; Jiang, X.C.
Subcellular targeting domains of sphingomyelin synthase 1 and 2
Nutr. Metab.
8
89
2011
Homo sapiens (Q86VZ5), Mus musculus (Q9D4B1)
Qureshi, A.; Subathra, M.; Grey, A.; Schey, K.; Del Poeta, M.; Luberto, C.
Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans
PLoS ONE
5
e15587
2010
Homo sapiens
Subathra, M.; Qureshi, A.; Luberto, C.
Sphingomyelin synthases regulate protein trafficking and secretion
PLoS ONE
6
e23644
2011
Homo sapiens, Rattus norvegicus
Barcelo-Coblijn, G.; Martin, M.L.; de Almeida, R.F.; Noguera-Salva, M.A.; Marcilla-Etxenike, A.; Guardiola-Serrano, F.; Lueth, A.; Kleuser, B.; Halver, J.E.; Escriba, P.V.
Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy
Proc. Natl. Acad. Sci. USA
108
19569-19574
2011
Homo sapiens
Piotto, S.; Concilio, S.; Bianchino, E.; Iannelli, P.; Lopez, D.J.; Teres, S.; Ibarguren, M.; Barcelo-Coblijn, G.; Martin, M.L.; Guardiola-Serrano, F.; Alonso-Sande, M.; Funari, S.S.; Busquets, X.; Escriba, P.V.
Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets
Biochim. Biophys. Acta
1838
1628-1637
2014
Homo sapiens
Sugimoto, M.; Shimizu, Y.; Zhao, S.; Ukon, N.; Nishijima, K.; Wakabayashi, M.; Yoshioka, T.; Higashino, K.; Numata, Y.; Okuda, T.; Tamaki, N.; Hanamatsu, H.; Igarashi, Y.; Kuge, Y.
Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice
Biochim. Biophys. Acta
1861
688-702
2016
Mus musculus (Q9D4B1), Mus musculus C57BL/6N (Q9D4B1)
Li, Y.L.; Qi, X.Y.; Jiang, H.; Deng, X.D.; Dong, Y.P.; Ding, T.B.; Zhou, L.; Men, P.; Chu, Y.; Wang, R.X.; Jiang, X.C.; Ye, D.Y.
Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors
Bioorg. Med. Chem.
23
6173-6184
2015
Homo sapiens (Q86VZ5)
Hu, S.; Ding, Y.; Song, D.; Chen, Q.; Yan, N.
Construction and identification of RNA interference vector of human sphingomyelin synthase
Fudan Univ. J. Med. Sci.
40
584-588
2013
Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3)
-
Thomaseth, C.; Weber, P.; Hamm, T.; Kashima, K.; Radde, N.
Modeling sphingomyelin synthase 1 driven reaction at the Golgi apparatus can explain data by inclusion of a positive feedback mechanism
J. Theor. Biol.
337
174-180
2013
Homo sapiens (Q86VZ5)
Huang, T.; Li, X.; Hu, S.; Zhao, B.; Chen, P.; Liu, X.; Ye, D.; Cheng, N.
Analysis of fluorescent ceramide and sphingomyelin analogs: a novel approach for in vivo monitoring of sphingomyelin synthase activity
Lipids
49
1071-1079
2014
Mus musculus (Q9D4B1)
Hu, S.; Ding, Y.; Gong, J.; Yan, N.
Sphingomyelin synthase 2 affects CD14-associated induction of NF kappaB by lipopolysaccharides in acute lung injury in mice
Mol. Med. Rep.
14
3301-3306
2016
Mus musculus (Q9D4B1), Mus musculus
Hsiao, J.H.; Fu, Y.; Hill, A.F.; Halliday, G.M.; Kim, W.S.
Elevation in sphingomyelin synthase activity is associated with increases in amyloid-beta peptide generation
PLoS ONE
8
e74016
2013
Homo sapiens (Q86VZ5), Homo sapiens
Deng, X.; Sun, H.; Gao, X.; Gong, H.; Lu, W.; Chu, Y.; Zhou, L.; Ye., D.
Development, validation, and application of a novel method for mammalian sphingomyelin synthase activity measurement
Anal. Lett.
45
1581-1589
2012
Mus musculus
-
Sakamoto, H.; Yoshida, T.; Sanaki, T.; Shigaki, S.; Morita, H.; Oyama, M.; Mitsui, M.; Tanaka, Y.; Nakano, T.; Mitsutake, S.; Igarashi, Y.; Takemoto, H.
Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response
Biochem. Biophys. Res. Commun.
482
202-207
2017
Mus musculus (Q9D4B1), Mus musculus
Prymas, K.; Swiatkowska, A.; Traczyk, G.; Ziemlinska, E.; Dziewulska, A.; Ciesielska, A.; Kwiatkowska, K.
Sphingomyelin synthase activity affects TRIF-dependent signaling of Toll-like receptor 4 in cells stimulated with lipopolysaccharide
Biochim. Biophys. Acta
1865
158549
2020
Mus musculus (Q8VCQ6), Mus musculus (Q9D4B1)
Yukawa, T.; Nakahata, T.; Okamoto, R.; Ishichi, Y.; Miyamoto, Y.; Nishimura, S.; Oikawa, T.; Kubo, K.; Adachi, R.; Satomi, Y.; Nakakariya, M.; Amano, N.; Kamaura, M.; Matsunaga, N.
Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor
Bioorg. Med. Chem.
28
115376
2020
Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3), Mus musculus (Q9D4B1)
Adachi, R.; Ogawa, K.; Matsumoto, S.; Satou, T.; Tanaka, Y.; Sakamoto, J.; Nakahata, T.; Okamoto, R.; Kamaura, M.; Kawamoto, T.
Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors
Eur. J. Med. Chem.
136
283-293
2017
Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3), Homo sapiens
Li, Y.; Huang, T.; Lou, B.; Ye, D.; Qi, X.; Li, X.; Hu, S.; Ding, T.; Chen, Y.; Cao, Y.; Mo, M.; Dong, J.; Wei, M.; Chu, Y.; Li, H.; Jiang, X.; Cheng, N.; Zhou, L.
Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor
Eur. J. Med. Chem.
163
864-882
2019
Homo sapiens (Q8NHU3)
Shi, X.; Zhang, H.; Chen, M.; Zhang, Y.; Zhu, M.; Zhang, M.; Li, F.; Wratten, S.; Zhou, W.; Mao, C.; Zhu, Z.
Two sphingomyelin synthase homologues regulate body weight and sphingomyelin synthesis in female brown planthopper, N.xa0lugens (Stal)
Insect Mol. Biol.
28
253-263
2019
Nilaparvata lugens
Zhang, P.; Hua, L.; Hou, H.; Du, X.; He, Z.; Liu, M.; Hu, X.; Yan, N.
Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/beta-catenin signaling pathway
Int. J. Mol. Med.
42
3344-3354
2018
Homo sapiens (Q8NHU3)
Gong, H.; Zhou, L.; Ye, D.; Gao, X.; Li, Y.; Qi, X.; Chu, Y.
Novel dual inhibitors of secretory phospholipase A2 and sphingomyelin synthase Design, synthesis and evaluation
Lett. Drug Des. Discov.
13
1025-1032
2016
Homo sapiens (Q8NHU3)
-
Li, X.; Luo, T.; Li, H.; Yan, N.
Sphingomyelin synthase 2 participate in the regulation of sperm motility and apoptosis
Molecules
25
4231
2020
Homo sapiens (Q8NHU3), Homo sapiens
Wittmann, A.; Grimm, M.O.; Scherthan, H.; Horsch, M.; Beckers, J.; Fuchs, H.; Gailus-Durner, V.; Hrabe de Angelis, M.; Ford, S.J.; Burton, N.C.; Razansky, D.; Truembach, D.; Aichler, M.; Walch, A.K.; Calzada-Wack, J.; Neff, F.; Wurst, W.; Hartmann, T.; Floss, T.
Sphingomyelin synthase 1 is essential for male fertility in mice
PLoS ONE
11
e0164298
2016
Mus musculus (Q8VCQ6), Mus musculus
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