Cloned (Comment) | Organism |
---|---|
overexpression of FLAG-tagged SMS1 or FLAG-tagged SMS2 in HeLa cells enhances de novo synthesis of sphingomyelin. expression of SMS1 and SMS2 viaSV40-transformation of WI38 fibroblasts, subcellular localization study, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | downregulation of SMS1 or SMS2 by siRNA oligonucleotides targeting SMS1 or SMS2 in HeLA cells reduces de novo synthesis of sphingomyelin, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi membrane | - |
Homo sapiens | 139 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | sphingomyelin synthases regulate production of diacylglycerol at the Golgi apparatus. Downregulation or up-regulation of SMS1 or SMS2 reduces or enhances de novo synthesis of sphingomyelin, pathway regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes SMS1 and SMS2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | sphingomyelin synthases regulate production of diacylglycerol at the Golgi apparatus. Downregulation or up-regulation of SMS1 or SMS2 reduces or enhances de novo synthesis of sphingomyelin, pathway regulation, overview | Homo sapiens | ? | - |
? | |
phosphatidylcholine + C6-ceramide | - |
Homo sapiens | ? | - |
? | |
phosphatidylcholine + C6-NBD-ceramide | i.e. N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine, the fluorogenic derivative of C6-ceramide | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SMS1 | - |
Homo sapiens |
SMS2 | - |
Homo sapiens |