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Literature summary for 2.7.8.27 extracted from

  • Sakamoto, H.; Yoshida, T.; Sanaki, T.; Shigaki, S.; Morita, H.; Oyama, M.; Mitsui, M.; Tanaka, Y.; Nakano, T.; Mitsutake, S.; Igarashi, Y.; Takemoto, H.
    Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response (2017), Biochem. Biophys. Res. Commun., 482, 202-207 .
    View publication on PubMed
Search for more literature for 2.7.8.27

Organism

Organism UniProt Comment Textmining
Mus musculus Q9D4B1 isoform SGMS2
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Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
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 Mus musculus
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liver
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 Mus musculus
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Synonyms

Synonyms Comment Organism
Sgms2
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 Mus musculus

General Information

General Information Comment Organism
physiological function in SMS2 knockout mice, SMS2 deficiency significantly decreases very long chain sphingomyelin (d18:1/22:0 and d18:1/24:0 or d18:0/24:1) and increases very long chain ceramie (d18:1/24:0 or d18:0/24:1 and d18:1/24:1), but not long chain sphingomyelin (d18:1/16:0, d18:1/18:0 or d18:0/18:1 and d18:1/18:1) in plasma. Presence of sphingomyelin d18:1/24:0 strongly upregulated several macrophage activation markers, sphingomyelin d18:1/6:0 and ceramide d18:1/24:0 however, does not Mus musculus