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EC Number	Activating Compound	Commentary	Reference
2.7.8.27	(S)-2-hydroxyoleic acid	a complex dual mechanism of action of 2-hydroxyoleic acid (2OHOA) as potent anti-tumor compound used in membrane lipid therapy (MLT). Only the S-enantiomer is able to activate enzyme SMS in human glioma U118 cells. The anti-tumor efficacy of the S-enantiomer is greater than that of the R-enantiomer, as the former can act through both membrane lipid therapy mechanisms, type-1 and type-2 MLT approaches. Molecular dynamics study indicates that both enantiomers interact similarly with lipid bilayers, molecular dynamics simulation, overview	737747
2.7.8.27	2-hydroxyoleic acid	enzyme activity is 3.6fold higher than in untreated cells after 24 h of treatment with 0.2 mM 2-hydroxyoleic acid. Activity increases 85% after 5 min of treatment	723643
2.7.8.27	more	early response of the SMS1 gene that can be induced by both ischemia and stress	691550
2.7.8.27	more	induction of SMS2 during Adjudin-induced AJ restructuring and disruption	669649
2.7.8.27	Thioacetamide	thioacetamide-induced increase in microsomal sphingomyelin by a stimulation of sphingomyelin synthase	668170

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Release 2023.1 (January 2023)