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ATP + 1,2-dibutanoylphosphatidylinositol 4,5-diphosphate
ADP + 1,2-dibutanoylphosphatidylinositol 3,4,5-trisphosphate
-
-
-
-
?
ATP + 1,2-dioctanoylphosphatidylinositol 4,5-diphosphate
ADP + 1,2-dioctanoylphosphatidylinositol 3,4,5-trisphosphate
-
-
-
-
?
ATP + 1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
ADP + ?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
ATP + Akt1
ADP + Akt1 phosphate
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 3,4-bisphosphate
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
ATP + phosphatidylinositol-4-phosphate
ADP + phosphatidylinositol-3,4-bisphosphate
phosphatidylinositol-4,5-bisphosphate + ATP
?
-
involved in signalling pathways leading to mitosis and differentiation
-
-
?
additional information
?
-
ATP + 1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol

ADP + ?
-
-
-
-
?
ATP + 1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
ADP + ?
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol

ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
catalyzed by class I and III, and probably by class II enzymes, overview. PI3K is part of the plasma membrane E-cadherin signaling complex
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
catalyzed by class I and III, and probably by class II enzymes, overview. PI3K is part of the plasma membrane E-cadherin signaling complex
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
-
-
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
substrate from bovine liver
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
TcVps34 specifically phosphorylates phosphatidylinositol to produce phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
TcVps34 specifically phosphorylates phosphatidylinositol to produce phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
-
?
ATP + 1-phosphatidylinositol

ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
Chlamydomonas sp.
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
hVps34 plays a major role in generating phosphatidylinositol 3-phosphate for internal vesicle formation in multivesicular/late endosomes. The findings also unexpectedly suggest that other wortmannin-sensitive kinases and/or polyphosphoinositide phosphatases may be able to compensate for the loss of hVps34 and maintain phosphatidylinositol 3-phosphate levels required for vesicular trafficking in the early endocytic pathway or the trans-Golgi network
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + Akt1

ADP + Akt1 phosphate
-
phosphorylation at Ser473
-
-
?
ATP + Akt1
ADP + Akt1 phosphate
-
phosphorylation at Ser473, a step in PI3K/Akt signaling
-
-
?
ATP + phosphatidylinositol

ADP + phosphatidylinositol 3-phosphate
-
class I enzyme, preferred substrate of the class III enzyme
-
-
?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
class I enzyme
-
-
?
ATP + phosphatidylinositol 4,5-bisphosphate

ADP + phosphatidylinositol 3,4,5-trisphosphate
-
weak activity
-
-
?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
no activity
-
-
-
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
-
no activity
-
-
-
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
-
class I enzyme, preferred substrate in vivo, physiologic regulation and mode of action
-
-
?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
-
class I enzyme, preferred substrate of the class I enzyme
-
-
?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
-
class I enzyme, preferred substrate in vivo
-
-
?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
-
class I enzyme
-
-
?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
-
-
-
?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
-
-
-
-
?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
-
-
-
-
-
ATP + phosphatidylinositol 4-phosphate

ADP + phosphatidylinositol 3,4-bisphosphate
-
weak activity
-
-
?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 3,4-bisphosphate
-
-
-
?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 3,4-bisphosphate
-
-
-
?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 3,4-bisphosphate
-
no activity
-
-
-
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 3,4-bisphosphate
-
class I enzyme, preferred substrate of the class II enzyme
-
-
?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 3,4-bisphosphate
-
class I enzyme
-
-
?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 3,4-bisphosphate
-
-
-
?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 3,4-bisphosphate
-
-
-
-
?
ATP + phosphatidylinositol-4,5-bisphosphate

ADP + phosphatidylinositol-3,4,5-trisphosphate
-
-
-
-
?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
-
class Ia isozyme
-
-
?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
-
synthesis of a second messenger, enzyme is involved in several cellular signaling processes important for cell growth and survival, cell differentiation and motility
-
-
?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
-
from rat liver and bovine erythrocyte and brain, substrate specificities, free or membrane anchored, phosphorylated phosphatidylinositol is poorer substrate than nonphosphorlyated, overview
-
-
?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
-
-
-
-
?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
-
-
-
-
?
ATP + phosphatidylinositol-4-phosphate

ADP + phosphatidylinositol-3,4-bisphosphate
-
-
-
-
?
ATP + phosphatidylinositol-4-phosphate
ADP + phosphatidylinositol-3,4-bisphosphate
-
synthesis of a second messenger, enzyme is involved in several cellular signaling processes important for cell growth and survival, cell differentiation and motility
-
-
?
ATP + phosphatidylinositol-4-phosphate
ADP + phosphatidylinositol-3,4-bisphosphate
-
-
-
-
?
ATP + phosphatidylinositol-4-phosphate
ADP + phosphatidylinositol-3,4-bisphosphate
-
-
-
-
?
additional information

?
-
PI3K binds to the V-ATPase subunit B2 (VHA-B2) in vitro and in vivo
-
-
-
additional information
?
-
-
enzyme plays an important role in the signalling of cell growth
-
-
-
additional information
?
-
-
enzyme might contribute to the antiproliferative activity of the antitumor ether lipid analogs
-
-
-
additional information
?
-
-
PI 3-kinase activity is a necessary step in the regulation of bone resorption
-
-
-
additional information
?
-
-
enzyme plays an important role in the signaling of cell growth
-
-
-
additional information
?
-
-
receptor linked enzyme may generate a second-messenger signal
-
-
-
additional information
?
-
regulating longevity and diapause
-
-
-
additional information
?
-
-
the enzyme is activated and associated to E-cadherin complexes, the assembly is mediated by docking proteins, e.g. beta-catenin, gamma-catenin, and Dlg, and involves c-SRC. Cell-cell adhesion induces c-SRC recruitment and E-cadherin complex assembly as well as activity of PI3K, regulatory and molecular mechanism, overview. PI3K, stimulated by E-cadherin adhesion, activates PKB/Akt
-
-
-
additional information
?
-
-
enzyme is involved in formyl peptide-induced stimulation of neutrophils
-
-
-
additional information
?
-
-
the level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase
-
-
-
additional information
?
-
role for Dp110 in growth control during Drosophila development
-
-
-
additional information
?
-
-
PI 3-kinase activity is a necessary step in the regulation of bone resorption
-
-
-
additional information
?
-
-
enzyme is induced during soybean nodule organogenesis and plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
-
-
-
additional information
?
-
enzyme is induced during soybean nodule organogenesis and plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
-
-
-
additional information
?
-
enzyme is induced during soybean nodule organogenesis and plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
-
-
-
additional information
?
-
-
PI3K plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
-
-
-
additional information
?
-
PI3K plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
-
-
-
additional information
?
-
PI3K plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
TAPP1 and TAPP2 are direct targets of PI3K signaling
-
-
-
additional information
?
-
-
activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity, activation is dependent on the phosphorylation event of p85
-
-
-
additional information
?
-
-
the enzyme is implicated in the control of breast cancer cell growth by free fatty acids and may provide a link between fat and cancer
-
-
-
additional information
?
-
-
important functional role of phosphatidylinositol 3-kinase in motile responses of HL-60 cells
-
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additional information
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monocytes respond to LPS with the rapid activation of PI 3-kinase, resulting in transient increases in levels of PtdIns 3,4,5-P3. This process is CD14 dependent and involves the physiological association of PI 3-kinase with activated p53/56lyn
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additional information
?
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role for phosphatidylinositol 3-kinase in the activation of Raf kinases in G protein-coupled receptor systems in human neutrophils
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additional information
?
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phosphatidylinositol 3-kinase-mediated signaling in the immune system
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additional information
?
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IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase
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additional information
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plays a central part in the mediation of insulin-stimulated glucose disposal
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additional information
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activation of PI3K is a critical component of the anti-Ig-initiated signaling cascade that leads to growth inhibition of human B lymphoma cells
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additional information
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myotubularin, a phosphatase deficient in myotubular myopathy, may decrease PI3P levels by down-regulating PI3K activity and by directly degrading PI3P
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additional information
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mitogenic signal transduction pathway mediated by P13K is dependent upon the enzymatic activity of the p110 alpha subunit of P13K
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additional information
?
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enzyme may represent a common pathway of integrin and adhesiveness regulation in leukocytes
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additional information
?
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class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity
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additional information
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enzyme is involved in the signaling pathways regulating cell growth by virtue of its activation in response to various mitogenic stimuli
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additional information
?
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the enzyme 3'-phosphorylates the inositol head group of membrane phosphoinositides, isozymes are subject to differential regulation and may play distinct roles in the cell, the enzyme is involved in many cellular responses important in pathogenesis of disease
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additional information
?
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the enzyme is involved in cytokin-stimulated cell migration
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additional information
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the enzyme interacts with other proteins and substrates via the pleckstrin homology PH domain
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additional information
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interaction between Beclin and hVps34 PI 3-kinase is essential for engagement of hVps34 in the process of macroautophagy, but is dispensable for the normal function of hVps34 in endocytic trafficking or lysosomal enzyme sorting
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additional information
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AMP-activated protein kinase, activated by energy depletion, inhibits cell survival by binding to and phosphorylating insulin receptor substrate-1 at Ser-794. Phosphorylation of insulin receptor substrate-1 at this site inhibits phosphatidylinositol 3-kinase/Akt signaling, suppresses the mitochondrial membrane potential, and promotes apoptosis
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additional information
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anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway
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additional information
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Hsp27 antagonizes Bax-mediated mitochondrial injury and apoptosis by promoting Akt activation via a PI3-kinase-dependent mechanism
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additional information
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IGF-I regulates the expression of FLIP in FRTL cells by activating the PI3K/NF-kB cascade
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additional information
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IL-2-induced PI3K activation limits IL-17RA gene expression. Blockade of the PI3K pathway but not p70S6K leads to up-regulation of IL-17RA
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additional information
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mTOR inhibition increases eIF4E phosphorylation through a PI3K-dependent and Mnk-mediated mechanism
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additional information
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PI 3-kinase signaling in proliferating cells regulates a novel program of gene expression, which is distinct from that induced by growth factor stimulation of quiescent cells. The expression program controlled by continuous PI 3-kinase signaling in proliferating cells is enriched in genes that regulate cell survival and is mediated in large part by FOXO and RelB transcription factors
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additional information
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the phosphatidylinositol 3-kinase/Akt signaling pathway is required for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes
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additional information
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PI3K family plays a prominent role in various inflammatory cells by controlling cell growth, differentiation, survival, proliferation, migration, and mediator production (such as cytokines) through its downstream components
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additional information
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class III PI3K Vps34p is associated with Vsp15
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additional information
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effects of the specific PI3K inhibtor LY294002 on Kv1.5 channels, wild-type and mutant, are independent of the effects on PI3K activity, overview
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additional information
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PI3K specifically interacts with retinoblastoma protein through the unique NH2 terminus of its regulatory subunit p55PIK, peptide N24. This interaction is critical for cell proliferation and cell cycle progression
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additional information
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the enzyme is activated and associated to E-cadherin complexes, the assembly is mediated by docking proteins, e.g. beta-catenin, gamma-catenin, and Dlg, and involves c-SRC. Cell-cell adhesion induces c-SRC recruitment and E-cadherin complex assembly as well as activity of PI3K, regulatory and molecular mechanism, overview. PI3K, stimulated by E-cadherin adhesion, activates PKB/Akt
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additional information
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Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes, overview. Atg14 interacts with Beclin 1 and Vps34 but not with UVRAG, the coiled-coil region of Atg14 required for binding with Vps34 and Beclin 1 is essential for autophagy
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additional information
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Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes, overview. Atg14 interacts with Beclin 1 and Vps34 but not with UVRAG, the coiled-coil region of Atg14 required for binding with Vps34 and Beclin 1 is essential for autophagy
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additional information
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Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes, overview. Atg14 interacts with Beclin 1 and Vps34 but not with UVRAG, the coiled-coil region of Atg14 required for binding with Vps34 and Beclin 1 is essential for autophagy
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additional information
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PI3-kinase activity is not required for starvation-induced Atg14 puncta formation
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additional information
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PI3-kinase activity is not required for starvation-induced Atg14 puncta formation
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additional information
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PI3-kinase activity is not required for starvation-induced Atg14 puncta formation
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additional information
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PI3K binds PD1 peptide, a 12-residue proline-rich peptide HSKRPLPPLPSL, and PD1R peptide, at the SH3 domain with type I ligand orientation of the bound peptide with an extended conformation where the central portion forms a left-handed type II polyproline, PPII, helix. The residue at anchor position P-3 is a tyrosine
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additional information
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the enzyme also catalyzes the reactions of EC 2.7.1.68, 1-phosphatidylinositol-4-phosphate 5-kinase, and EC 2.7.1.67, 1-phosphatidylinositol 4-kinase
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additional information
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class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity
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additional information
?
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the enzyme 3'-phosphorylates the inositol head group of membrane phosphoinositides, isozymes are subject to differential regulation and may play distinct roles in the cell, e.g. in cell survival, vesicle trafficking, cytoskeletal reorganization, and chemotaxis, the enzymeis involved in diverse signalling pathways, detailed schematic overview
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additional information
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the enzyme interacts with other proteins and substrates via the pleckstrin homology PH domain, class I isozyme subgroups Ia and Ib are divided due to their mode of action and structure
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additional information
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additional information
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PI-3-kinase might be involved in the induction of erythroid differentiation, possibly engaging a protein kinase C z as downstream effector
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additional information
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the enzyme catalyzes the formation of 3'-phosphoinositides, which appear to promote cellular responses to growth factors and such membrane trafficking events as insulin-stimulated translocation of intracellular glucose transporters
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additional information
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may play a role in phosphatidylinositol 3-kinase-mediated signaling in the immune system
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additional information
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phosphatidylinositol 3-kinase-mediated signaling in the immune system
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additional information
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phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
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additional information
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insulin stimulation of fatty acid synthase promoter is mediated by the PI 3-kinase pathway
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additional information
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enzyme might contribute to the antiproliferative activity of the antitumor ether lipid analogs
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additional information
?
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differential regulation of insulin receptor substrate-1 and insulin receptor substrate-2 and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic mouse
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additional information
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insulin activates ATP-sensitive K+ channels in pancreatic B-cells through a phosphatidylinositol 3-kinase-dependent pathway
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additional information
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reduced expression of the murine p85a subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
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additional information
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enzyme could be involved in stimulated glucose transport in muscle
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additional information
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the isozyme gamma stimulates the protein kinases Erk, JNK, and PKB and thus plays a role in cellular signaling, overview
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additional information
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phosphoinositide quantification via labeled and/or tagged ligands binding to the pleckstrin homology PH domain of the enzyme in competition with phosphoinositides, overview
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additional information
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the enzyme shows both lipid and protein kinase activity
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additional information
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leptin activates leptin receptor and results in the actvation of insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300, leading to up-regulation of IL-6 expression
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additional information
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type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3
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additional information
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lutein inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways
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additional information
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raloxifene exerts its anti-inflammatory action in LPS-stimulated macrophages by blocking the PI 3-kinase-Akt-NF-kappaB signaling cascade, and eventually reduces expression of pro-inflammatory genes such as the nitric oxide synthase gene
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additional information
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activated PDGFRbeta interacts with PI3 kinase, which binds to the phosphorylated Tyr739 and Tyr750 residues, in the signaling cascade in vascular smooth muscle cells. disruption of PDGFRbeta-PI3K signaling in mice reduces atherosclerosis. PDGF-BB-induced chemotaxis is inhibited by blocking PI3K activation through PDGFRbeta
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additional information
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PI3K signaling, overview
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additional information
?
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PI3K signaling, overview
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additional information
?
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two populations of p27 use different kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation
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additional information
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two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation
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additional information
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additional information
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isoform p110b of the catalytic subunit plays a crucial role in cellular activities evoked acutely by insulin
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additional information
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PI 3-kinase is the first step of the insulin signaling pathway to be impaired by high-fat feeding
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additional information
?
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essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes
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additional information
?
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PI 3-K pathways is involved in the short-term activation of pyruvate kinase L by insulin in rat hepatocytes
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additional information
?
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insulin signaling in heart involves insulin receptor substrate-1 and insulin receptor substrate-2, activation of phosphatidylinositol 3-kinase
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additional information
?
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signaling pathways for phosphoinositolglycan-peptide and insulin to glucose transport and metabolism converge at the level of PI 3-kinase
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additional information
?
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PI 3-kinase activity appears to be an important component of ovariectomy-stimulated bone loss in rats
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additional information
?
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insulin and dexamethasone regulate phosphatidylinositol 3-kinase in Fao hepatoma cells
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additional information
?
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insulin-stimulated IRS-1 association with PI 3-kinase is decreased to 84% in the liver and to 84% in the muscle in the fructose-fed group compared to controls
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additional information
?
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in both the liver and muscle of high salt-fed rats, intracellular insulin signaling leading to PI 3-kinase activation is enhanced and insulin action is attenuated
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additional information
?
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multiple defects of PI 3-kinase activation, involving both the p85a and the p85b adaptor subunits, may contribute to cardiac insulin resistance
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additional information
?
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the enzyme is involved in beta2-adrenergic receptor/G1-mediated compartmentation of the concurrent Gs-cAMP signaling, negating beta2-AR-induced phospholamban phosphorylation and the positive inotropic and lusitropic responses in cardiomyocytes, regulation of enzyme activity in cell signaling cascades, effects of enzyme inhibition on cellular processes, detailed overview
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additional information
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the lipid-lowering effect of leptin on livers from lean rats is mediated by the enzyme, diet-induced obesity abolishes the effect of leptin on the enzyme and the lipid level and causes leptin resistance
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additional information
?
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PI3-kinase-dependent activation of diacylglycerol kinase and production of phosphatidic acid in caveolae/rafts in response to norepinephrine but not endothelin-1
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additional information
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HMG-CoA reductase inhibitor regulates endothelial progenitor function through the phosphatidylinositol 3-kinase/AKT signal transduction pathway
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additional information
?
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nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb
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additional information
?
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activation of PI3K by adenosine leads to induction of hemeoxygenase-1, HO-1, expression in microglia
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additional information
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PI3K is implicated in the phosphorylation of ERK and CaMKII in spinal neurons, and of NR2B subunits of the NMDA receptor, as well as in the increased synthesis of c-Fos and the trafficking of AMPA-R GluR1 subunit, all after formalin injection
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additional information
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a p110alpha/beta-subunit binds to a p85 regulatory subunit, and this heterodimer is recruited to the membrane through the association with phosphotyrosyl proteins, leading to production of phosphatidylinositol 3,4,5-triphosphate, PIP3, followed by activation of downstream signal pathway(s)
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additional information
?
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nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb
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additional information
?
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HMG-CoA reductase inhibitor regulates endothelial progenitor function through the phosphatidylinositol 3-kinase/AKT signal transduction pathway
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additional information
?
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enzyme is required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae
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additional information
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enzyme is required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae
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additional information
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the enzyme is essential for protein sorting
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additional information
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essential for normal cell growth and vacuole morphology
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additional information
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PI3K inhibits recombinantly expressed rat excitatory amino acid transporter 4 in oocytes, which is inhibited by the specific PI3K inhibitor wortmannin
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additional information
?
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generation of phosphatidyl 3,4,5-triphosphate by phosphatidylinositol 3-kinase is necessary for insulin-induced germinal vesicle breakdown in Xenopus oocytes
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additional information
?
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lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a phosphatidylinositol 3'-kinase
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additional information
?
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overexpression of mkrn2 completely abrogates constitutively active PI3K- and Akt-induced, but not dominant negative glycogen synthase kinase-3beta-induced, neural cell adhesion molecule expression, indicating that mkrn2 acts downstream of PI3K and Akt and upstream of GSK-3beta. Important role of mkrn2 as a new player in PI3K/Akt-mediated neurogenesis during Xenopus embryonic development
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ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
hVps34 plays a major role in generating phosphatidylinositol 3-phosphate for internal vesicle formation in multivesicular/late endosomes. The findings also unexpectedly suggest that other wortmannin-sensitive kinases and/or polyphosphoinositide phosphatases may be able to compensate for the loss of hVps34 and maintain phosphatidylinositol 3-phosphate levels required for vesicular trafficking in the early endocytic pathway or the trans-Golgi network
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ATP + Akt1
ADP + Akt1 phosphate
-
phosphorylation at Ser473, a step in PI3K/Akt signaling
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?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
ATP + phosphatidylinositol-4-phosphate
ADP + phosphatidylinositol-3,4-bisphosphate
phosphatidylinositol-4,5-bisphosphate + ATP
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involved in signalling pathways leading to mitosis and differentiation
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?
additional information
?
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ATP + 1-phosphatidyl-1D-myo-inositol

ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
catalyzed by class I and III, and probably by class II enzymes, overview. PI3K is part of the plasma membrane E-cadherin signaling complex
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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-
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-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
catalyzed by class I and III, and probably by class II enzymes, overview. PI3K is part of the plasma membrane E-cadherin signaling complex
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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-
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-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
TcVps34 specifically phosphorylates phosphatidylinositol to produce phosphatidylinositol 3-phosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
TcVps34 specifically phosphorylates phosphatidylinositol to produce phosphatidylinositol 3-phosphate
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-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
-
-
-
?
ATP + phosphatidylinositol 4,5-bisphosphate

ADP + phosphatidylinositol 3,4,5-trisphosphate
-
class I enzyme, preferred substrate in vivo, physiologic regulation and mode of action
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-
?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
-
class I enzyme, preferred substrate in vivo
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-
?
ATP + phosphatidylinositol 4,5-bisphosphate
ADP + phosphatidylinositol 3,4,5-trisphosphate
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-
-
-
?
ATP + phosphatidylinositol-4,5-bisphosphate

ADP + phosphatidylinositol-3,4,5-trisphosphate
-
-
-
-
?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
-
class Ia isozyme
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-
?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
-
synthesis of a second messenger, enzyme is involved in several cellular signaling processes important for cell growth and survival, cell differentiation and motility
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-
?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
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-
-
-
?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
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-
-
-
?
ATP + phosphatidylinositol-4-phosphate

ADP + phosphatidylinositol-3,4-bisphosphate
-
synthesis of a second messenger, enzyme is involved in several cellular signaling processes important for cell growth and survival, cell differentiation and motility
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-
?
ATP + phosphatidylinositol-4-phosphate
ADP + phosphatidylinositol-3,4-bisphosphate
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-
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-
?
ATP + phosphatidylinositol-4-phosphate
ADP + phosphatidylinositol-3,4-bisphosphate
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-
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-
?
additional information

?
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PI3K binds to the V-ATPase subunit B2 (VHA-B2) in vitro and in vivo
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-
-
additional information
?
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enzyme plays an important role in the signalling of cell growth
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-
additional information
?
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enzyme might contribute to the antiproliferative activity of the antitumor ether lipid analogs
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-
-
additional information
?
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-
PI 3-kinase activity is a necessary step in the regulation of bone resorption
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additional information
?
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enzyme plays an important role in the signaling of cell growth
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additional information
?
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receptor linked enzyme may generate a second-messenger signal
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additional information
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regulating longevity and diapause
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additional information
?
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the enzyme is activated and associated to E-cadherin complexes, the assembly is mediated by docking proteins, e.g. beta-catenin, gamma-catenin, and Dlg, and involves c-SRC. Cell-cell adhesion induces c-SRC recruitment and E-cadherin complex assembly as well as activity of PI3K, regulatory and molecular mechanism, overview. PI3K, stimulated by E-cadherin adhesion, activates PKB/Akt
-
-
-
additional information
?
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-
enzyme is involved in formyl peptide-induced stimulation of neutrophils
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-
-
additional information
?
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-
the level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase
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-
additional information
?
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role for Dp110 in growth control during Drosophila development
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additional information
?
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PI 3-kinase activity is a necessary step in the regulation of bone resorption
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additional information
?
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enzyme is induced during soybean nodule organogenesis and plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
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additional information
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enzyme is induced during soybean nodule organogenesis and plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
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additional information
?
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enzyme is induced during soybean nodule organogenesis and plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
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additional information
?
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PI3K plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
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additional information
?
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PI3K plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
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additional information
?
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PI3K plays a pivotal role in development of the peribacteroid membrane forming a subcellular compartment
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-
additional information
?
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additional information
?
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TAPP1 and TAPP2 are direct targets of PI3K signaling
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additional information
?
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activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity, activation is dependent on the phosphorylation event of p85
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additional information
?
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the enzyme is implicated in the control of breast cancer cell growth by free fatty acids and may provide a link between fat and cancer
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additional information
?
-
-
important functional role of phosphatidylinositol 3-kinase in motile responses of HL-60 cells
-
-
-
additional information
?
-
-
monocytes respond to LPS with the rapid activation of PI 3-kinase, resulting in transient increases in levels of PtdIns 3,4,5-P3. This process is CD14 dependent and involves the physiological association of PI 3-kinase with activated p53/56lyn
-
-
-
additional information
?
-
-
role for phosphatidylinositol 3-kinase in the activation of Raf kinases in G protein-coupled receptor systems in human neutrophils
-
-
-
additional information
?
-
-
phosphatidylinositol 3-kinase-mediated signaling in the immune system
-
-
-
additional information
?
-
-
IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase
-
-
-
additional information
?
-
-
plays a central part in the mediation of insulin-stimulated glucose disposal
-
-
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additional information
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activation of PI3K is a critical component of the anti-Ig-initiated signaling cascade that leads to growth inhibition of human B lymphoma cells
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additional information
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myotubularin, a phosphatase deficient in myotubular myopathy, may decrease PI3P levels by down-regulating PI3K activity and by directly degrading PI3P
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additional information
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mitogenic signal transduction pathway mediated by P13K is dependent upon the enzymatic activity of the p110 alpha subunit of P13K
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additional information
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enzyme may represent a common pathway of integrin and adhesiveness regulation in leukocytes
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additional information
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class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity
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additional information
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enzyme is involved in the signaling pathways regulating cell growth by virtue of its activation in response to various mitogenic stimuli
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additional information
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the enzyme 3'-phosphorylates the inositol head group of membrane phosphoinositides, isozymes are subject to differential regulation and may play distinct roles in the cell, the enzyme is involved in many cellular responses important in pathogenesis of disease
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additional information
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the enzyme is involved in cytokin-stimulated cell migration
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additional information
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interaction between Beclin and hVps34 PI 3-kinase is essential for engagement of hVps34 in the process of macroautophagy, but is dispensable for the normal function of hVps34 in endocytic trafficking or lysosomal enzyme sorting
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additional information
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AMP-activated protein kinase, activated by energy depletion, inhibits cell survival by binding to and phosphorylating insulin receptor substrate-1 at Ser-794. Phosphorylation of insulin receptor substrate-1 at this site inhibits phosphatidylinositol 3-kinase/Akt signaling, suppresses the mitochondrial membrane potential, and promotes apoptosis
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additional information
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anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway
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additional information
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Hsp27 antagonizes Bax-mediated mitochondrial injury and apoptosis by promoting Akt activation via a PI3-kinase-dependent mechanism
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additional information
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IGF-I regulates the expression of FLIP in FRTL cells by activating the PI3K/NF-kB cascade
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additional information
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IL-2-induced PI3K activation limits IL-17RA gene expression. Blockade of the PI3K pathway but not p70S6K leads to up-regulation of IL-17RA
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additional information
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mTOR inhibition increases eIF4E phosphorylation through a PI3K-dependent and Mnk-mediated mechanism
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additional information
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PI 3-kinase signaling in proliferating cells regulates a novel program of gene expression, which is distinct from that induced by growth factor stimulation of quiescent cells. The expression program controlled by continuous PI 3-kinase signaling in proliferating cells is enriched in genes that regulate cell survival and is mediated in large part by FOXO and RelB transcription factors
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additional information
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the phosphatidylinositol 3-kinase/Akt signaling pathway is required for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes
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additional information
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class III PI3K Vps34p is associated with Vsp15
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additional information
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effects of the specific PI3K inhibtor LY294002 on Kv1.5 channels, wild-type and mutant, are independent of the effects on PI3K activity, overview
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additional information
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PI3K specifically interacts with retinoblastoma protein through the unique NH2 terminus of its regulatory subunit p55PIK, peptide N24. This interaction is critical for cell proliferation and cell cycle progression
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additional information
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the enzyme is activated and associated to E-cadherin complexes, the assembly is mediated by docking proteins, e.g. beta-catenin, gamma-catenin, and Dlg, and involves c-SRC. Cell-cell adhesion induces c-SRC recruitment and E-cadherin complex assembly as well as activity of PI3K, regulatory and molecular mechanism, overview. PI3K, stimulated by E-cadherin adhesion, activates PKB/Akt
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additional information
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Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes, overview. Atg14 interacts with Beclin 1 and Vps34 but not with UVRAG, the coiled-coil region of Atg14 required for binding with Vps34 and Beclin 1 is essential for autophagy
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additional information
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Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes, overview. Atg14 interacts with Beclin 1 and Vps34 but not with UVRAG, the coiled-coil region of Atg14 required for binding with Vps34 and Beclin 1 is essential for autophagy
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additional information
?
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Vps34, p150, Beclin 1, Atg14, and UVRAG form two distinct class III phosphatidylinositol 3-kinase complexes, overview. Atg14 interacts with Beclin 1 and Vps34 but not with UVRAG, the coiled-coil region of Atg14 required for binding with Vps34 and Beclin 1 is essential for autophagy
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additional information
?
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class II PI3K enzymes may contribute to the generation of 3'-phosphoinositides following the activation of polypeptide growth factor receptors in vivo and thus mediate certain aspects of their biological activity
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additional information
?
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the enzyme 3'-phosphorylates the inositol head group of membrane phosphoinositides, isozymes are subject to differential regulation and may play distinct roles in the cell, e.g. in cell survival, vesicle trafficking, cytoskeletal reorganization, and chemotaxis, the enzymeis involved in diverse signalling pathways, detailed schematic overview
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additional information
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additional information
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PI-3-kinase might be involved in the induction of erythroid differentiation, possibly engaging a protein kinase C z as downstream effector
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additional information
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the enzyme catalyzes the formation of 3'-phosphoinositides, which appear to promote cellular responses to growth factors and such membrane trafficking events as insulin-stimulated translocation of intracellular glucose transporters
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additional information
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may play a role in phosphatidylinositol 3-kinase-mediated signaling in the immune system
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additional information
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phosphatidylinositol 3-kinase-mediated signaling in the immune system
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additional information
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phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
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additional information
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insulin stimulation of fatty acid synthase promoter is mediated by the PI 3-kinase pathway
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additional information
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enzyme might contribute to the antiproliferative activity of the antitumor ether lipid analogs
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additional information
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differential regulation of insulin receptor substrate-1 and insulin receptor substrate-2 and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic mouse
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additional information
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insulin activates ATP-sensitive K+ channels in pancreatic B-cells through a phosphatidylinositol 3-kinase-dependent pathway
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additional information
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reduced expression of the murine p85a subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
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additional information
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enzyme could be involved in stimulated glucose transport in muscle
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additional information
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the isozyme gamma stimulates the protein kinases Erk, JNK, and PKB and thus plays a role in cellular signaling, overview
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additional information
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leptin activates leptin receptor and results in the actvation of insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300, leading to up-regulation of IL-6 expression
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additional information
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type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3
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additional information
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lutein inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways
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additional information
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raloxifene exerts its anti-inflammatory action in LPS-stimulated macrophages by blocking the PI 3-kinase-Akt-NF-kappaB signaling cascade, and eventually reduces expression of pro-inflammatory genes such as the nitric oxide synthase gene
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additional information
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activated PDGFRbeta interacts with PI3 kinase, which binds to the phosphorylated Tyr739 and Tyr750 residues, in the signaling cascade in vascular smooth muscle cells. disruption of PDGFRbeta-PI3K signaling in mice reduces atherosclerosis. PDGF-BB-induced chemotaxis is inhibited by blocking PI3K activation through PDGFRbeta
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additional information
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PI3K signaling, overview
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additional information
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PI3K signaling, overview
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additional information
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two populations of p27 use different kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation
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additional information
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two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation
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additional information
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additional information
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isoform p110b of the catalytic subunit plays a crucial role in cellular activities evoked acutely by insulin
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additional information
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PI 3-kinase is the first step of the insulin signaling pathway to be impaired by high-fat feeding
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additional information
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essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes
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additional information
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PI 3-K pathways is involved in the short-term activation of pyruvate kinase L by insulin in rat hepatocytes
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additional information
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insulin signaling in heart involves insulin receptor substrate-1 and insulin receptor substrate-2, activation of phosphatidylinositol 3-kinase
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additional information
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signaling pathways for phosphoinositolglycan-peptide and insulin to glucose transport and metabolism converge at the level of PI 3-kinase
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additional information
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PI 3-kinase activity appears to be an important component of ovariectomy-stimulated bone loss in rats
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additional information
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insulin and dexamethasone regulate phosphatidylinositol 3-kinase in Fao hepatoma cells
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additional information
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insulin-stimulated IRS-1 association with PI 3-kinase is decreased to 84% in the liver and to 84% in the muscle in the fructose-fed group compared to controls
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additional information
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in both the liver and muscle of high salt-fed rats, intracellular insulin signaling leading to PI 3-kinase activation is enhanced and insulin action is attenuated
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additional information
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multiple defects of PI 3-kinase activation, involving both the p85a and the p85b adaptor subunits, may contribute to cardiac insulin resistance
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additional information
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the enzyme is involved in beta2-adrenergic receptor/G1-mediated compartmentation of the concurrent Gs-cAMP signaling, negating beta2-AR-induced phospholamban phosphorylation and the positive inotropic and lusitropic responses in cardiomyocytes, regulation of enzyme activity in cell signaling cascades, effects of enzyme inhibition on cellular processes, detailed overview
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additional information
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the lipid-lowering effect of leptin on livers from lean rats is mediated by the enzyme, diet-induced obesity abolishes the effect of leptin on the enzyme and the lipid level and causes leptin resistance
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additional information
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PI3-kinase-dependent activation of diacylglycerol kinase and production of phosphatidic acid in caveolae/rafts in response to norepinephrine but not endothelin-1
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additional information
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HMG-CoA reductase inhibitor regulates endothelial progenitor function through the phosphatidylinositol 3-kinase/AKT signal transduction pathway
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additional information
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nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb
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additional information
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activation of PI3K by adenosine leads to induction of hemeoxygenase-1, HO-1, expression in microglia
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additional information
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PI3K is implicated in the phosphorylation of ERK and CaMKII in spinal neurons, and of NR2B subunits of the NMDA receptor, as well as in the increased synthesis of c-Fos and the trafficking of AMPA-R GluR1 subunit, all after formalin injection
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additional information
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nerve growth factor inhibits Na+/H+ exchange and formula absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb
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additional information
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HMG-CoA reductase inhibitor regulates endothelial progenitor function through the phosphatidylinositol 3-kinase/AKT signal transduction pathway
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additional information
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enzyme is required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae
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additional information
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enzyme is required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae
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additional information
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the enzyme is essential for protein sorting
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additional information
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essential for normal cell growth and vacuole morphology
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additional information
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PI3K inhibits recombinantly expressed rat excitatory amino acid transporter 4 in oocytes, which is inhibited by the specific PI3K inhibitor wortmannin
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additional information
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generation of phosphatidyl 3,4,5-triphosphate by phosphatidylinositol 3-kinase is necessary for insulin-induced germinal vesicle breakdown in Xenopus oocytes
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additional information
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lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a phosphatidylinositol 3'-kinase
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additional information
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overexpression of mkrn2 completely abrogates constitutively active PI3K- and Akt-induced, but not dominant negative glycogen synthase kinase-3beta-induced, neural cell adhesion molecule expression, indicating that mkrn2 acts downstream of PI3K and Akt and upstream of GSK-3beta. Important role of mkrn2 as a new player in PI3K/Akt-mediated neurogenesis during Xenopus embryonic development
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(+/-)-2-[hydroxy[tetrahydro-2-(octadecyloxy)methylfuran-2-yl]methoxyl]phosphinyloxy-N,N,N-trimethylethaniminium hydroxide
(1E,4S,4aR,5R,6aS,7S)-5-(acetyloxy)-1-[[[3-(dimethylamino)-propyl](methyl)amino]methylene]-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-7-yl-(1R,2R,4S)-4-[(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriaconti
-
-
-
(1E,4S,4aR,5R,6aS,7S)-5-(acetyloxy)-1-{[[3-(dimethylamino)propyl](methyl)amino]methylene}-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-7-yl-(1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin
-
-
-
(1E,4S,4aR,5R,6aS,7S,9aR)-1-({[3-(dimethylamino)propyl](methyl)amino}methylidene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a,9a-trimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate
-
-
(1Z,4S,4aR,6aS,9aR)-1-([[3-(dimethylamino)propyl](methyl)amino]methylidene)-5-ethoxy-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-4a,5,6,6a,7,8,9,9a-octahydroindeno[4,5-h]isochromene-2,10(1H,4H)-dione
-
-
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-[(2R)-1-[(1S,3R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
-
-
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R)-3-hydroxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
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-
1-((3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)methyl)guanidine
i.e. idelalisib
1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
2-morpholin-4-yl-3-phenylchromen-4-one
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weak inhibition, IC50 is above 0.2 mM for the recombinant wild-type enzyme and for the recombinant mutant C838V/I848A
2-morpholin-4-yl-3-propylchromen-4-one
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IC50 is 0.0031 mM for the recombinant wild-type enzyme and 0.068 mM for the recombinant mutant C838V/I848A
3-benzyl-2-morpholin-4-yl-chromen-4-one
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weak inhibition, IC50 is above 0.2 mM for the recombinant wild-type enzyme and for the recombinant mutant C838V/I848A
3-butyl-2-morpholin-4-yl-chromen-4-one
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IC50 is 0.025 mM for the recombinant wild-type enzyme and 0.048 mM for the recombinant mutant C838V/I848A
3-ethyl-2-morpholin-4-yl-chromen-4-one
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IC50 is 0.028 mM for the recombinant wild-type enzyme and 0.0044 mM for the recombinant mutant C838V/I848A
3-isopropyl-2-morpholin-4-yl-chromen-4-one
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IC50 is 0.051 mM for the recombinant wild-type enzyme and more than 0.2 mM for the recombinant mutant C838V/I848A
3-methyl-2-morpholin-4-yl-chromen-4-one
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IC50 is 0.033 mM for the recombinant wild-type enzyme and 0.040 mM for the recombinant mutant C838V/I848A
5'-p-fluorosulfonylbenzoyladenosine
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-
apocynin
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specific PI3K inhibitor, restores vasorelaxation and hyperpolarization in response to an ATP-sensitive K+ channel opener levcromakalim
Ca2+
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0.1 mM, 60% inhibition, in presence of 10 mM MgCl2
ethanol
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dose-dependent inhibition of insulin receptor substrate-1-associated PI3K activity in skeletal muscle, but not in adipose tissue, ethanol-induced diabetic rats
GDC-0941
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enzyme PI3K-inhibition via GDC-0941 and PTEN-reconstitution into PTEN-null follicular thyroid carcinomas FTC-133s. GDC-0941 inhibits radiation-induced activation of Ataxia-telangiectasia mutated (ATM), ATM-and Rad3-related (ATR) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Under anoxia, radiation-induced PI3K-related kinase activation is markedly inhibited by GDC-0941. Inhibition of ATM and DNA-protein kinase catalytic subunits is PI3K-dependent
Gö6976
inhibitor directly targets phosphatidylinositol 3-kinase and confers profound inhibition of autophagic flux by inhibiting the formation of autophagosomes. It does not inhibit the cell survival promoting class I phosphoinositide 3-kinase-Akt signaling at the concentrations required for effective autophagy inhibition
isoquercetin
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PI 3-kinase I and PI 3-kinase II; strong inhibition of PI 3-kinase I and II, noncompetitive, apparent Ki value: 4 mM for PI 3-kinase I and 2.5 mM for PI 3-kinase II
KU55933
inhibitor directly targets phosphatidylinositol 3-kinase and confers profound inhibition of autophagic flux by inhibiting the formation of autophagosomes. Inhibits wild-type activity in vitro almost as efficiently as LY294002. It does not inhibit the cell survival promoting class I phosphoinositide 3-kinase-Akt signaling at the concentrations required for effective autophagy inhibition
LY292223
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i.e. 2-morpholin-4-yl-chromen-4-one, IC50 is 0.0026 mM for the recombinant wild-type enzyme and 0.025 mM for the recombinant mutant C838V/I848A
LY303511
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the inhibitor potently, reversibly blocks voltage-dependent K+ channel currents via a direct mechanism, IC50 is 0.065 mM
lysophosphatidic acid
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-
Mg2+
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inhibition above 2.5 mM, activation below
peptide N24
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a peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase, N24, regulatory subunit acts as inhibitor in cancer therapy, it blocks cell proliferation and induces cell cycle arrest in all cancer cell lines tested. Modeling of mechanisms of Rb-dependent and Rb-independent cell cycle arrest by N24 peptide, overview
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PI3Kalpha inhibitor IV
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-
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PI3Kbeta inhibitor VI
-
i.e. TGX-221
-
PI3Kgamma inhibitor
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-
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TGFbeta
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significantly inhibits phosphorylation of both p85 and ERK1/2 in vivo. TGFbeta does not activate the ERK pathway but turns off the GM-CSF-induced ERK signal via inhibition of the PI3-kinase-Akt pathway in human leukemia cells, overview
-
Tiron
-
specific PI3K inhibitor, restores vasorelaxation and hyperpolarization in response to an ATP-sensitive K+ channel opener levcromakalim
ZSTK474
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a phosphatidylinositol 3-kinase inhibitor, inhibited phosphorylation of Ser65, Thr70 and Thr37/46 in 4E-BP1 by PI3K. Identification of the ZSTK474-sensitive phosphoproteins in A-549 cells, overview
(+/-)-2-[hydroxy[tetrahydro-2-(octadecyloxy)methylfuran-2-yl]methoxyl]phosphinyloxy-N,N,N-trimethylethaniminium hydroxide

-
-
(+/-)-2-[hydroxy[tetrahydro-2-(octadecyloxy)methylfuran-2-yl]methoxyl]phosphinyloxy-N,N,N-trimethylethaniminium hydroxide
-
-
1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol

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-
1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
-
-
1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine

-
noncompetitive with ATP
1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
-
noncompetitive with ATP
17-hydroxywortmannin

-
-
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

-
i.e. LY294002
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
-
i.e. LY294002
3-Methyladenine

-
treatment in full medium for a prolonged period of time leads to marked increases of the autophagic markers in cells. The increase of autophagic markers is the result of enhanced autophagic flux. The autophagy promotion activity is due to its differential temporal effects on class I and class III PI3K enzymes. 3-Methyladenine blocks class I PI3K persistently, whereas its suppressive effect on class III PI3K is transient. Treatment with 3-methyladenine in full medium significantly reduces the level of phosphatidylinositol 3-phosphate, the product of class III PI3K, at early time points, but almost completely blocks the product of phosphatidylinositol 3,4,5-trisphosphate up to 9 h
3-Methyladenine
-
treatment in full medium for a prolonged period of time leads to marked increases of the autophagic markers in cells. The increase of autophagic markers is the result of enhanced autophagic flux. The autophagy promotion activity is due to its differential temporal effects on class I and class III PI3K enzymes. 3-Methyladenine blocks class I PI3K persistently, whereas its suppressive effect on class III PI3K is transient. Treatment with 3-methyladenine in full medium significantly reduces the level of phosphatidylinositol 3-phosphate, the product of class III PI3K, at early time points, but almost completely blocks the product of phosphatidylinositol 3,4,5-trisphosphate up to 9 h
cardiolipin

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hexadecylphosphocholine

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-
hexadecylphosphocholine
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-
LY294002

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a PI3Kspecific inhibitor, inhibition in vivo: in LY294002-treated root hair cells, endocytosis at the stage of final fusion of the late endosomes to the tonoplast is inhibited and ROS level decreases in a dose-dependent manner, overview
LY294002
competes with ATP and binds to Lys residues in the ATP-binding pocket of PI3Ks
LY294002
-
i.e. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, a specific cell-permeable PI3-K inhibitor, inhibits spermatozoa motility at 40°C, not at 30°C, independent of and not reversable by Ca2+
LY294002
-
-
640885, 685788, 686034, 688155, 688453, 707040, 708417, 708568, 709207, 709870, 710681
LY294002
-
IC50 is 0.0011 mM for the recombinant wild-type enzyme and for the recombinant mutant C838V/I848A
LY294002
-
the inhibitor activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901
LY294002
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could suppress leukemia cell invasion and migration at least in part through up-regulation of Egr-1, independent of its PI3 K-Akt inhibitory activity
LY294002
-
inhibition of PI3K by LY294002 broadly sensitizes wild-type and mutant PTEN glioblastoma cells to both death receptor and chemotherapy-induced apoptosis
LY294002
-
simultaneous inhibition of the mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase pathways enhances sensitivity to paclitaxel in ovarian carcinoma
LY294002
-
the inhibitor markedly suppresses phosphorylation of Akt and accelerates TRAIL-mediated apoptosis in oral squamous cell carcinoma cell
LY294002
-
inhibition of PI 3-K enhances the susceptibility of oral squamous cell carcinoma cells to anticancer drug-mediated apoptosis through regulation of expression and post-translational modification of both pro- and antiapoptotic proteins
LY294002
-
the specific inhibitor of the phosphatidylinositol 3-kinase upregulates beta1,4-galactosyltransferase I and thus sensitizes SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis. PI3K inhibitors might have therapeutic potential when combined with cycloheximide in the treatment of hepatoma
LY294002
-
i.e. [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]
LY294002
-
specific PI3K inhibtor, effects of LY294002 on Kv1.5 channels, wild-type and mutant, are independent of the effects on PI3K activity, overview
LY294002
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acts synergistically with the leukotriene biosynthesis inhibitor MK591, overview
LY294002
-
a potent inhibitor of PI3-kinase, significantly inhibits phosphorylation of both p85 and ERK1/2 in vivo
LY294002
-
specific PI3K inhibitor, restores vasorelaxation and hyperpolarization in response to an ATP-sensitive K+ channel opener levcromakalim
LY294002
inhibits wild-type activity in vitro almost as efficiently as KU55933, but is required at much higher concentrations for efficient inhibition of autophagy
LY294002
-
specific inhibitor
LY294002
-
specific inhibition
LY294002
-
preclinical evidence for the in vivo efficacy for LY294002 in the treatment of follicular thyroid cancer
LY294002
-
significantly inhibits retinal neovascularization in a mouse model of retinal neovascularization
LY294002
-
a PI3K antagonist
LY294002
-
application inhibits rice seed germination and the expression of NADPK oxidase
LY294002
-
specific inhibition
LY294002
-
the inhibitor potently, reversibly blocks voltage-dependent K+ channel currents via a direct mechanism, IC50 is 0.009 mM, potentiates glucose-stimulated insulin secretion from MIN6 cells in vivo
LY294002
-
inhibition of PI3-kinase induces apoptotic cell death, which is mediated by inactivation of Akt pathway in rat osteoblasts
LY294002
-
may modulate function of the glycine transporters GlyT1 independent of PI3 kinase inhibition
LY294002
-
a specific inhibitor of PI3K, effectively suppresses the microglia-derived plasminogen-dependent phosphorylation of Akt
LY294002
-
i.e. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, a potent PI3K inhibitor, in vitro and vivo inhibition. Spinal application of LY294002 reduces the wind-up of deep dorsal WDR neurons and inhibits electrically evoked responses. Electrically evoked substance P release is not inhibited by LY294002
LY294002
-
IC50 values: 2 mM
LY294002
-
inhibits sperm-induced activation of the tyrosine kinase Src and a transient increase in the intracellular concentration of Ca2+ at fertilization. LY294002 also has an inhibitory effect on the Ca2+-dependent breakdown of the Mos protein kinase and cyclin B2 as well as dephosphorylation of mitogenactivated protein kinase
LY301497

-
-
Nonidet P40

-
-
NVP-BEZ235

-
the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin catalytic inhibitor, interferes with tumor growth likely by affecting tumor cells and their vasculature system
NVP-BEZ235
-
potency and selectivity for efficient P13K pathway blockade, potent in vivo antitumor activity
NVP-BEZ235
-
a mTOR/phosphatidylinositol 3-kinase inhibitor. Effector lapatinib and the PI3K inhibitor NVP-BEZ235 collaborate to suppress the PI3K-AKT-mTOR axis driven by loss-offunction PTEN mutations, overview
phosphatidylcholine

-
strong inhibition of enzyme form PI3KII, weak inhibition of enzyme form PI3KI
PWT-458

-
i.e. poly(oxy-1,2-ethanediyl)-, R-[2-[[2-[[(1S,6bR,9S,9aS,11R,11bR)-11-(acetyloxy)-1,6,6b,7,8,9,9a,10,11,11b-decahydro-1-(methoxymethyl)-9a,11b-dimethyl-3,6-dioxo-3Hfuro[4,3,2-de]indeno[4,5-h]-2-benzopyran-9-yl]oxy]-2-oxoethyl]thio]ethyl]-omega-methoxy
PWT-458
-
i.e. poly(oxy-1,2-ethanediyl)-, R-[2-[[2-[[(1S,6bR,9S,9aS,11R,11bR)-11-(acetyloxy)-1,6,6b,7,8,9,9a,10,11,11b-decahydro-1-(methoxymethyl)-9a,11b-dimethyl-3,6-dioxo-3Hfuro[4,3,2-de]indeno[4,5-h]-2-benzopyran-9-yl]oxy]-2-oxoethyl]thio]ethyl]-omega-methoxy
PX-866

-
potent inhibitor of cancer cell motility and growth in three-dimensional cultures
PX-866
-
i.e. acetic acid 4-diallylaminomethylene-6-hydroxy-1-alpha-methoxymethyl-10beta,13beta-dimethyl-3,7,17-trioxo-1,3,4,7,10,11beta,12,13,14alpha,15,16,17-dodecahydro-2-oxacyclopenta[a]phenanthren-11-yl ester
PX-866
-
i.e. acetic acid 4-diallylaminomethylene-6-hydroxy-1-alpha-methoxymethyl-10beta,13beta-dimethyl-3,7,17-trioxo-1,3,4,7,10,11beta,12,13,14alpha,15,16,17-dodecahydro-2-oxacyclopenta[a]phenanthren-11-yl ester
quercetin

-
inhibition of PI 3-kinase I and II; PI 3-kinase I and PI 3-kinase II, non-competitive
quercetin
-
5 mM, 70% inhibition
Wortmannin

-
Wortmannin
-
inhibition is of a noncompetitive type with regard to ATP, observed with phosphatidylinositol, phosphatidylinositol monophosphate, or phosphatidylinositol bisphosphate as substrate
Wortmannin
-
PI3K-C2a is refractory to
Wortmannin
-
; at nanomolar levels
Wortmannin
-
phosphoinositide 3-kinase with a C2 domain displays reduced sensitivity to the inhibitor wortmannin
Wortmannin
-
inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens
Wortmannin
-
the inhibitor markedly suppresses phosphorylation of Akt and accelerates TRAIL-mediated apoptosis in oral squamous cell carcinoma cell
Wortmannin
-
inhibition of PI 3-K enhances the susceptibility of oral squamous cell carcinoma cells to anticancer drug-mediated apoptosis through regulation of expression and post-translational modification of both pro- and antiapoptotic proteins
Wortmannin
-
the specific inhibitor of the phosphatidylinositol 3-kinase upregulates beta1,4-galactosyltransferase I and thus sensitizes SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis. PI3K inhibitors might have therapeutic potential when combined with cycloheximide in the treatment of hepatoma
Wortmannin
-
an irreversible inhibitor with pan-PI3K activity
Wortmannin
-
treatment with wortmannin results in sustained reduction of phosphatidylinositol 3-phosphate and a transient effect on production of phosphatidylinositol 3,4,5-trisphosphate with recovery after 9 h
Wortmannin
-
specific inhibitor
Wortmannin
-
specific irreversible inhibition, binds covalently to the active site, mixed type inhibition, IC50 is 12 nM
Wortmannin
-
a PI3K antagonist
Wortmannin
-
an irreversible inhibitor with pan-PI3K activity
Wortmannin
-
treatment with wortmannin results in sustained reduction of phosphatidylinositol 3-phosphate and a transient effect on production of phosphatidylinositol 3,4,5-trisphosphate with recovery after 9 h
Wortmannin
-
application inhibits rice seed germination and the expression of NADPK oxidase
Wortmannin
-
specific inhibition, no blockage of whole-cell outward K+ currents
Wortmannin
-
a specific PI 3-K inhibitor
Wortmannin
-
intracerebroventricular injection of leptin significantly increases phosphodiesterase 3B activity by twofold in the hypothalamus. Previous administration of wortmannin, a specific PI3K inhibitor, completely reverses the stimulatory effect of leptin on phosphodiesterase 3B activity in the hypothalamus
additional information

-
chelation of intracellular Ca2+
-
additional information
-
LY303511, i.e. 2-(4-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one, is an inactive analogue of LY294002
-
additional information
-
no inhibition by resveratrol, i.e. 3,4',5-trihydroxystilbene, which is an inhibitor of type II phosphatidylinositol 4-kinase
-
additional information
-
tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling
-
additional information
-
MK591 does not inhibit PI3K
-
additional information
-
small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth. The inhibitors affect beta-catenin signaling by inhibition of GSK-3beta activity, resulting in cytoplasmic retention of beta-catenin and reduced expression of its target genes cyclin D1 and c-Myc
-
additional information
-
drug design and synthesis, 17-hydroxywortmannin analogues conjugated to rapamycin analogues via a prodrug linker , inhibitory potency, overview
-
additional information
-
the PI3K-related kinase proteins share significant sequence homology with PI3K, therefore drugs targeting PI3K may also inhibit PI3K-related kinase, PIKK, activity
-
additional information
-
downstream lipid products affect the enzyme activity via effectors
-
additional information
-
no inhibition by 5,6-dichlorobenzimidazole
-
additional information
inhibition of TcVps34 with specific PI3K inhibitors, such as wortmannin and LY294000, result in reduced regulatory volume decrease after hyposmotic stress
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