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Literature summary for 2.3.1.299 extracted from

  • Wang, Z.; Wen, L.; Zhu, F.; Wang, Y.; Xie, Q.; Chen, Z.; Li, Y.
    Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma (2017), Oncotarget, 8, 104022-104036 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine the combined therapy of enzyme and teniposide VM-26 is a therapeutic strategy for the treatment of human glioma Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
stearoyl-CoA + a sphingoid base Homo sapiens
-
 an N-(stearoyl)-sphingoid base + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-172 cell
-
 Homo sapiens
-
brain
-
 Homo sapiens
-
central nervous system
-
 Homo sapiens
-
glioma cell
-
 Homo sapiens
-
U-251MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
stearoyl-CoA + a sphingoid base
-
 Homo sapiens an N-(stearoyl)-sphingoid base + CoA
-
 ?

Synonyms

Synonyms Comment Organism
ceramide synthase 1
-
 Homo sapiens
CerS1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme overexpression inhibits cell viability and induces cell death by activating endoplasmic reticulum stress, which induces lethal autophagy and inhibits PI3K/AKT signal pathway in U-251 and A-172 glioma cells. Enzyme overexpression also increases the sensitivity of U-251 and A-172 glioma cells to teniposide (VM-26) Homo sapiens