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Information on EC 2.3.1.299 - sphingoid base N-stearoyltransferase

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IUBMB Comments
Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 1 (CERS1) is structurally and functionally distinctive from all other CERS enzymes, and is specific for stearoyl-CoA as the acyl donor. It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine.
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The enzyme appears in viruses and cellular organisms
Synonyms
(dihydro)-ceramide synthase, (dihydro)ceramide synthase, ceramide synthase, ceramide synthase 1, CerS1, LASS1, longevity assurance homologue 1, longevity assurance homologue 1 of yeast Lag1, mammalian ceramide synthase 1, More, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
stearoyl-CoA + a sphingoid base = an N-(stearoyl)-sphingoid base + CoA
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PATHWAY SOURCE
PATHWAYS
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