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BRENDA support

Information on EC 2.3.1.299 - sphingoid base N-stearoyltransferase

for references in articles please use BRENDA:EC2.3.1.299

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IUBMB Comments

Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 1 (CERS1) is structurally and functionally distinctive from all other CERS enzymes, and is specific for stearoyl-CoA as the acyl donor. It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine.

The enzyme appears in viruses and cellular organisms

Synonyms
cers1, lass1, ceramide synthase 1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
stearoyl-CoA + a sphingoid base = an N-(stearoyl)-sphingoid base + CoA
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
Highest Expressing Human Cell Lines
Cell Line Links Gene Links