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Information on EC 2.7.12.2 - mitogen-activated protein kinase kinase
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2.7.12.2 mitogen-activated protein kinase kinaseIUBMB Comments
This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues . Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
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Word Map
- 2.7.12.2
- mapks
- c-jun
- 3-kinase
- endothelial
- phosphatidylinositol
- mek1
- pkc
- necrosis
- agonist
- melanoma
- metastasis
- camp
- sirnas
- egf
- raf-1
- bcl-2
- cyclins
- c-fos
-
dominant-negative
- erk2
- rapamycin
-
stress-activated
-
phorbol
- wortmannin
- caspase-3
- nf-kappab
- phosphoinositide
- mtor
- trametinib
- creb
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kinase-dependent
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platelet-derived
- pertussis
-
mek-erk
-
brafv600e
-
ras-mediated
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p21ras
- agriculture
- p38alpha
- elk-1
-
ras-induced
-
dual-specificity
-
extracellular-regulated
-
signal-related
-
p90rsk
-
ras-dependent
- drug development
- rsk
- medicine
- analysis
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braf-mutant
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egf-induced
- phospho-erk
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erk-dependent
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
mek/erk, mitogen-activated protein kinase kinase, map kinase kinase, mapkk, mek-1, extracellular-signal-regulated kinase, mapk/erk kinase, map2k4, erk 1, mitogen-activated protein kinase kinase 1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ASK1
BcOs4
BOS5
dual specificity mitogen-activated protein kinase kinase 1
dual specificity mitogen-activated protein kinase kinase 2
dual specificity mitogen-activated protein kinase kinase 3
dual specificity mitogen-activated protein kinase kinase 4
dual specificity mitogen-activated protein kinase kinase 5
dual specificity mitogen-activated protein kinase kinase 6
dual specificity mitogen-activated protein kinase kinase 7
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dual specificity mitogen-activated protein kinase kinase dSOR1
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dual specificity mitogen-activated protein kinase kinase hemipterous
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dual specificity mitogen-activated protein kinase kinase mek-2
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ERK
extracellular signal-regulated kinase
extracellular-signal-regulated kinase
MAP kinase kinase
MAP kinase kinase 4
MAPK kinase
MAPK/Erk kinase
MAPKK
MAPKK1
MAPKK3
MEK
MEK-2
MEK1
MEK1/2
MEK2
MEK5
mitogen activated protein kinase kinase
mitogen activated protein kinase kinase 6
mitogen-activated protein kinase kinase
mitogen-activated protein kinase kinase 1
mitogen-activated protein kinase kinase 2
mitogen-activated protein kinase kinase 3
mitogen-activated protein kinase kinase 4
mitogen-activated protein kinase kinase kinase 2
mitogen-activated protein kinase kinase kinase 3
mitogen-activated protein kinase kinase kinase 5
mitogen-activated protein kinase kinase/extracellular signalregulated kinase
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mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1
-
mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 2
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MKK
MKK1
MKK2
MKK3
MKK4
MKK5
MKK6
MKK7
MKK9
OsMKK4
polymyxin B resistance protein kinase
-
serine/threonine protein kinase STE7
-
stress kinase mitogen-activated protein kinase kinase 7
stress-activate protein kinase/extracellular signal-regulated protein kinase kinase-1
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-
Tb10.70.1800
Tb927.10.5270
Tb927.3.4860
VdPbs2
additional information
dual specificity mitogen-activated protein kinase kinase 1
-
dual specificity mitogen-activated protein kinase kinase 1
-
dual specificity mitogen-activated protein kinase kinase 1
-
dual specificity mitogen-activated protein kinase kinase 1
-
dual specificity mitogen-activated protein kinase kinase 2
-
dual specificity mitogen-activated protein kinase kinase 2
-
dual specificity mitogen-activated protein kinase kinase 3
-
dual specificity mitogen-activated protein kinase kinase 4
-
dual specificity mitogen-activated protein kinase kinase 6
-
mitogen activated protein kinase kinase
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
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-
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SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (MAPKKK-activated)
This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues [5]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
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CAS REGISTRY NUMBER
COMMENTARY
142805-58-1
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