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BRENDA support

Literature summary for 2.4.1.225 extracted from

  • Ushakov, V.; Tsidulko, A.; De La Bourdonnaye, G.; Kazanskaya, G.; Volkov, A.; Kiselev, R.; Kobozev, V.; Kostromskaya, D.; Gaytan, A.; Krivoshapkin, A.; Aidagulova, S.; Grigorieva, E.
    Heparan sulfate biosynthetic system is inhibited in human glioma due to EXT1/2 and HS6ST1/2 down-regulation (2017), Int. J. Mol. Sci., 18, 2301 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16394
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-
Homo sapiens Q93063
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-

Source Tissue

Source Tissue Comment Organism Textmining
glioma cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
EXT1
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Homo sapiens
EXT2
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the overall transcriptional activity of the main heparan sulfate biosynthesis-involved genes (EXT1, EXT2, NDST1,NDST2, GLCE, HS2ST1, HS3ST1, HS3ST2, HS6ST1, HS6ST2, SULF1, SULF2, HPSE) is decreased by 1.5-2fold in Grade II-III glioma (p < 0.01) and by 3-fold in Grade IV glioma (glioblastoma multiforme, GBM) (p < 0.05), as compared with the para-tumourous tissue down

General Information

General Information Comment Organism
physiological function the enzyme is involved in heparan sulfate biosynthesis Homo sapiens