Inhibitors | Comment | Organism | Structure |
---|---|---|---|
plasminogen activator inhibitor type-1 | i.e. PAI-1, an endogenous inhibitor protein | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain cortex | - |
Homo sapiens | - |
ganglioma cell | - |
Homo sapiens | - |
glial cell | - |
Homo sapiens | - |
glioma cell | - |
Homo sapiens | - |
hippocampus | - |
Homo sapiens | - |
additional information | increased uPA expression in several epileptogenic pathologies, including hippocampal sclerosis, and in developmental glioneuronal lesions, such as focal cortical dysplasia, cortical tubers in patients with the tuberous sclerosis complex and in gangliogliomas, immunohistochemic analysis, overview | Homo sapiens | - |
neuronal cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
uPA | - |
Homo sapiens |
Urokinase plasminogen activator | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | uPA overexpression in brain cortex and hippocampus is involved in epileptic pathology | Homo sapiens |
physiological function | uPA elicits various cellular responses, involving the activation of distinct signaling pathways | Homo sapiens |