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Literature summary for 1.14.11.66 extracted from
- The role of histone demethylase GASC1 in cancer and its therapeutic potential (2013), Curr. Cancer. Ther. Rev., 9, 78-85 .
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (R)-2-hydroxyglutarate | - |
Homo sapiens |  |
| (S)-2-hydroxyglutarate | - |
Homo sapiens | |
| 5-(anilinomethyl)quinolin-8-ol | - |
Homo sapiens | |
| caffeic acid | - |
Homo sapiens | |
| dimethyl 4-hydroxy-1H-pyrazole-3,5-dicarboxylate | - |
Homo sapiens | |
| methylstat | - |
Homo sapiens | |
| N-oxalylglycine | - |
Homo sapiens | |
| NCDM-32 | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | Homo sapiens | overall reaction | [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
| [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
| [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | Homo sapiens | - |
[histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
| [polycomb 2 protein]-N6,N6-dimethyl-L-lysine191 + 2-oxoglutarate + O2 | Homo sapiens | - |
[polycomb 2 protein]-N6-methyl-L-lysine191 + succinate + formaldehyde + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Homo sapiens | - |
| colorectal cancer cell | - |
Homo sapiens | - |
| esophageal squamous cell carcinoma cell | - |
Homo sapiens | - |
| glioma cell | - |
Homo sapiens | - |
| hepatoma cell | - |
Homo sapiens | - |
| lung cancer cell | - |
Homo sapiens | - |
| medulloblastoma cell | - |
Homo sapiens | - |
| ovary cancer cell | - |
Homo sapiens | - |
| prostate gland cancer cell | - |
Homo sapiens | - |
| renal cell carcinoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 | overall reaction | Homo sapiens | [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
| [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
| [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Homo sapiens | [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? | |
| [polycomb 2 protein]-N6,N6-dimethyl-L-lysine191 + 2-oxoglutarate + O2 | - |
Homo sapiens | [polycomb 2 protein]-N6-methyl-L-lysine191 + succinate + formaldehyde + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GASC1 | gene name, gene amplified in squamous cell carcinoma 1 | Homo sapiens |
| JMJD2C | - |
Homo sapiens |
| Kdm4c | - |
Homo sapiens |
| lysine-specific demethylase 4C | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | NCDM-32 | |
| 0.0021 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-(anilinomethyl)quinolin-8-ol | |
| 0.0034 | - |
pH and temperature not specified in the publication | Homo sapiens | methylstat | |
| 0.0137 | - |
pH and temperature not specified in the publication | Homo sapiens | caffeic acid | |
| 0.079 | - |
pH and temperature not specified in the publication | Homo sapiens | (R)-2-hydroxyglutarate | |
| 0.097 | - |
pH and temperature not specified in the publication | Homo sapiens | (S)-2-hydroxyglutarate | |
| 0.147 | - |
pH and temperature not specified in the publication | Homo sapiens | dimethyl 4-hydroxy-1H-pyrazole-3,5-dicarboxylate | |
| 0.5 | - |
pH and temperature not specified in the publication | Homo sapiens | N-oxalylglycine | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | enzyme over-production may induce alterations in epigenetic histone methylation and affects the expression of key genes that are implicated in carcinogenesis and stem cell properties in human cancer | Homo sapiens |
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