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(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
(gamma-L-glutamyl)-L-serine
5-oxoproline + L-serine
-
-
-
-
?
2-amino-5-(butan-2-ylamino)-5-oxopentanoic acid
DL-proline + (S)-butan-2-amine
-
-
-
-
?
2-amino-5-(cyclohexylamino)-5-oxopentanoic acid
DL-proline + cyclohexylamine
-
-
-
-
?
2-amino-5-(cyclopropylamino)-5-oxopentanoic acid
DL-proline + cyclopropylamine
-
-
-
-
?
2-amino-5-(tert-butylamino)-5-oxopentanoic acid
DL-proline + tert-butylamine
-
-
-
-
?
2-amino-5-oxo-5-(propan-2-ylamino)pentanoic acid
DL-proline + propan-2-amine
-
-
-
-
?
2-amino-5-[(2-methylbutyl)amino]-5-oxopentanoic acid
DL-proline + (RS)-2-methylbutan-1-amine
-
-
-
-
?
2-amino-5-[(2S)-butan-2-ylamino]-5-oxopentanoic acid
DL-proline + (S)-butan-2-amine
-
-
-
-
?
2-amino-5-[[(2S)-2-methylbutyl]amino]-5-oxopentanoic acid
DL-proline + (2S)-2-methylbutan-1-amine
-
-
-
-
?
2-N-(5-L-glutamyl)L-lysine
5-oxoproline + L-lysine
-
-
-
?
5-(4-methyl)glutamyl-L-2-aminobutyrate
3-methyl-5-oxoproline + L-alpha-aminobutyrate
-
substrate analog, 90% as effective as 5-glutamyl-L-2-aminobutyrate
-
?
5-glutamyl-glutathione
5-oxoproline + glutathione
5-L-(threo-2-methyl)glutamyl-L-alpha-aminobutyrate
?
-
-
-
-
?
5-L-(threo-4-methyl)glutamyl-L-2-aminobutyrate
3-methyl-5-oxoproline + L-alpha-aminobutyrate
5-L-glutamyl-(+)-3-aminobutyric acid
5-oxoproline + (+)-3-aminbutyric acid
-
-
-
-
?
5-L-glutamyl-(+)-3-aminoisobutyric acid
5-oxoproline + (+)-3-aminoisobutyric acid
-
-
-
-
?
5-L-glutamyl-1-naphthylamide
5-oxoproline + naphthylamine
5-L-glutamyl-5-L-glutamyl-4-nitroanilide
5-oxoproline + 5-L-glutamyl-4-nitroanilide
5-L-glutamyl-5-L-glutamyl-glycine
5-oxoproline + 5-L-glutamyl-glycine
5-L-glutamyl-5-L-glutamyl-L-alanine
5-oxoproline + 5-L-glutamyl-L-alanine
5-L-glutamyl-5-L-glutamyl-L-amino acid
5-oxoproline + 5-L-glutamyl-L-amino acid
5-L-glutamyl-5-L-glutamyl-L-glutamate
5-oxoproline + 5-L-glutamyl-L-glutamate
5-L-glutamyl-5-L-glutamyl-L-glutamine
5-oxoproline + 5-L-glutamyl-L-glutamine
5-L-glutamyl-5-L-glutamyl-L-leucine
5-oxoproline + 5-L-glutamyl-L-leucine
5-L-glutamyl-5-L-glutamyl-L-lysine
5-oxoproline + 5-L-glutamyl-L-lysine
5-L-glutamyl-5-L-glutamyl-L-phenylalanine
5-oxoproline + 5-L-glutamyl-L-phenylalanine
5-L-glutamyl-5-L-glutamyl-L-proline
5-oxoproline + 5-L-glutamyl-L-proline
5-L-glutamyl-5-L-glutamyl-L-threonine
5-oxoproline + 5-L-glutamyl-L-threonine
5-L-glutamyl-5-L-glutamyl-L-tyrosine
5-oxoproline + 5-L-glutamyl-L-tyrosine
5-L-glutamyl-5-L-glutamyl-L-valine
5-oxoproline + 5-L-glutamyl-L-valine
5-L-glutamyl-anilide
5-oxoproline + aniline
-
-
-
-
?
5-L-glutamyl-benzylamine
5-oxoproline + benzylamine
-
-
-
-
?
5-L-glutamyl-beta-alanine
5-oxoproline + beta-alanine
-
-
-
-
?
5-L-glutamyl-beta-phenethylamine
5-oxoproline + beta-phenethylamine
-
-
-
-
?
5-L-glutamyl-cyclopentylamine
5-oxoproline + cyclopentylamine
-
-
-
-
?
5-L-glutamyl-cysteine
5-oxoproline + L-cysteine
-
-
-
?
5-L-glutamyl-ethylamine
5-oxoproline + ethylamine
-
-
-
-
?
5-L-glutamyl-glycine
5-oxoproline + glycine
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
5-L-glutamyl-L-6-N-benzyloxycarbonyl-L-lysine
5-oxoproline + L-6-N-benzyloxycarbonyl-L-lysine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
5-L-glutamyl-L-alanine
5-oxoproline + L-alanine
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
5-L-glutamyl-L-aspartate
5-oxoproline + L-aspartate
5-L-glutamyl-L-cysteine
5-oxoproline + L-cysteine
5-L-glutamyl-L-glutamate
5-oxoproline + L-glutamate
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
5-L-glutamyl-L-isoleucine
5-oxoproline + L-isoleucine
-
very low activity
-
?
5-L-glutamyl-L-leucine
5-oxoproline + L-leucine
5-L-glutamyl-L-methionine
5-oxoproline + L-methionine
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
5-L-glutamyl-L-proline
5-oxoproline + L-proline
-
very low activity
-
?
5-L-glutamyl-L-tyrosine
5-oxoproline + L-tyrosine
-
very low activity
-
?
5-L-glutamyl-L-valine
5-oxoproline + L-valine
5-L-glutamyl-methylamine
5-oxoproline + methylamine
-
-
-
-
?
5-L-glutamyl-n-butylamine
5-oxoproline + butylamine
-
-
-
-
?
5-L-glutamyl-n-propylamine
5-oxoproline + propylamine
-
-
-
-
?
5-L-glutamyl-neohexylamine
5-oxoproline + neohexylamine
-
-
-
-
?
5-L-glutamyl-neopentylamine
5-oxoproline + neopentylamine
-
-
-
-
?
5-L-glutamyl-S-methyl-L-cysteine
5-oxoproline + S-methyl-L-cysteine
alpha-N-(gamma-L-glutamyl)-L-lysine
L-lysine + 5-oxo-L-proline
-
-
-
-
?
D-gamma-glutamyl-O-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]-L-serine
5-oxoproline + O-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]-L-serine
-
-
-
-
?
gamma-glutamyl-Cys + H2O
5-oxoproline + L-cysteine
-
assay at 30°C, pH 8.0, 60 min, 48 microl substrate, reaction stopped with 6 microl HCl
-
-
?
gamma-glutamyl-L-alanine
5-oxoproline + alanine
-
-
-
?
gamma-L-Glu-epsilon-N-benzyloxycarbonyl-L-Lys
epsilon-N-benzyloxycarbonyl-L-Lys + 5-oxo-L-proline
-
-
-
?
gamma-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
Gln-2-naphthylamide
pyroglutamyl-2-naphthylamide + NH3
-
-
-
-
?
Gln1-containing peptide
pyroglutamyl peptide
-
-
-
-
?
Glu-2-naphthylamide
?
-
-
-
-
?
glutathione
5-oxoproline + L-Cys-Gly
L-2-amino-3-(3-n-butylureido)-propionic acid
?
-
-
-
-
?
L-gamma-glutamyl-L-epsilon-lysine
5-oxoproline + L-lysine
-
-
-
?
L-gamma-glutamyl-O-[(4-methylumbelliferyl)carbonyl]-L-serine
(2S)-2-amino-3-([[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]oxy)propanoic acid + 5-oxo-L-proline
fluorogenic probe
-
-
?
N5-((S)-1-carboxy-3-(ethyl(((3-oxo-3H-phenoxazin-7-yl)oxy)carbonyl)amino)propyl)-L-glutamine
(2S)-2-amino-4-(ethyl[[(3-oxo-3H-phenoxazin-7-yl)oxy]carbonyl]amino)butanoic acid + 5-oxo-L-proline
fluorogenic probe
-
-
?
Nepsilon-(5-L-glutamyl)-D-lysine
?
-
-
-
-
?
Nepsilon-(5-L-glutamyl)-L-lysine
5-oxoproline + L-lysine
O-(n-butylcarbamyl)-L-serine
?
-
-
-
-
?
S-(cyclohexylamine)-L-cysteine
?
-
-
-
-
?
S-(n-butylcarbamyl)-L-cysteine
?
-
-
-
-
?
S-(n-propylcarbamyl)-L-cysteine
?
-
-
-
-
?
additional information
?
-
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
-
-
-
-
?
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
-
-
-
?
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
-
-
-
?
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
-
-
-
-
?
5-glutamyl-glutathione
5-oxoproline + glutathione
-
-
-
?
5-glutamyl-glutathione
5-oxoproline + glutathione
-
-
-
?
5-L-(threo-4-methyl)glutamyl-L-2-aminobutyrate
3-methyl-5-oxoproline + L-alpha-aminobutyrate
-
model substrate, in vivo and in vitro
-
?
5-L-(threo-4-methyl)glutamyl-L-2-aminobutyrate
3-methyl-5-oxoproline + L-alpha-aminobutyrate
-
model substrate, in vivo and in vitro
-
?
5-L-(threo-4-methyl)glutamyl-L-2-aminobutyrate
3-methyl-5-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-(threo-4-methyl)glutamyl-L-2-aminobutyrate
3-methyl-5-oxoproline + L-alpha-aminobutyrate
-
model substrate, in vivo and in vitro
-
?
5-L-glutamyl-1-naphthylamide
5-oxoproline + naphthylamine
-
best substrate
-
?
5-L-glutamyl-1-naphthylamide
5-oxoproline + naphthylamine
-
best substrate
-
?
5-L-glutamyl-5-L-glutamyl-4-nitroanilide
5-oxoproline + 5-L-glutamyl-4-nitroanilide
-
-
-
-
?
5-L-glutamyl-5-L-glutamyl-4-nitroanilide
5-oxoproline + 5-L-glutamyl-4-nitroanilide
-
-
-
-
?
5-L-glutamyl-5-L-glutamyl-glycine
5-oxoproline + 5-L-glutamyl-glycine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-glycine
5-oxoproline + 5-L-glutamyl-glycine
-
high activity
-
?
5-L-glutamyl-5-L-glutamyl-glycine
5-oxoproline + 5-L-glutamyl-glycine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-alanine
5-oxoproline + 5-L-glutamyl-L-alanine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-alanine
5-oxoproline + 5-L-glutamyl-L-alanine
-
high activity
-
?
5-L-glutamyl-5-L-glutamyl-L-alanine
5-oxoproline + 5-L-glutamyl-L-alanine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-amino acid
5-oxoproline + 5-L-glutamyl-L-amino acid
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-amino acid
5-oxoproline + 5-L-glutamyl-L-amino acid
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-amino acid
5-oxoproline + 5-L-glutamyl-L-amino acid
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-glutamate
5-oxoproline + 5-L-glutamyl-L-glutamate
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-glutamate
5-oxoproline + 5-L-glutamyl-L-glutamate
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-glutamine
5-oxoproline + 5-L-glutamyl-L-glutamine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-glutamine
5-oxoproline + 5-L-glutamyl-L-glutamine
-
high activity
-
?
5-L-glutamyl-5-L-glutamyl-L-glutamine
5-oxoproline + 5-L-glutamyl-L-glutamine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-leucine
5-oxoproline + 5-L-glutamyl-L-leucine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-leucine
5-oxoproline + 5-L-glutamyl-L-leucine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-lysine
5-oxoproline + 5-L-glutamyl-L-lysine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-lysine
5-oxoproline + 5-L-glutamyl-L-lysine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-phenylalanine
5-oxoproline + 5-L-glutamyl-L-phenylalanine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-phenylalanine
5-oxoproline + 5-L-glutamyl-L-phenylalanine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-proline
5-oxoproline + 5-L-glutamyl-L-proline
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-proline
5-oxoproline + 5-L-glutamyl-L-proline
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-threonine
5-oxoproline + 5-L-glutamyl-L-threonine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-threonine
5-oxoproline + 5-L-glutamyl-L-threonine
-
high activity
-
?
5-L-glutamyl-5-L-glutamyl-L-tyrosine
5-oxoproline + 5-L-glutamyl-L-tyrosine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-tyrosine
5-oxoproline + 5-L-glutamyl-L-tyrosine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-valine
5-oxoproline + 5-L-glutamyl-L-valine
-
-
-
?
5-L-glutamyl-5-L-glutamyl-L-valine
5-oxoproline + 5-L-glutamyl-L-valine
-
-
-
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
-
-
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
-
-
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
poor substrate
-
-
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
-
-
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
-
-
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
-
-
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
poor substrate
-
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
poor substrate
-
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
poor substrate
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
best substrate
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
best substrate
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
25% as effective as 5-L-glutamyl-L-phenylalanine
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
no activity with D-glutamyl-isomer
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
best substrate
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
best substrate
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
-
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
-
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
-
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-oxoproline + L-alanine
-
low activity compared to glutathione
-
-
?
5-L-glutamyl-L-alanine
5-oxoproline + L-alanine
-
low activity compared to glutathione
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
-
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
stereospecific
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with LD-, DD- and DL-isomers of 5-L-glutamyl-5-L-glutamyl-4-nitroanilide
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with L-glutamine
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with L-glutamine
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with: glutathione, i.e. gamma-L-glutamyl-L-cysteinylglycine
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with L-glutamyl-beta-alanine, L-glutamyl-3-aminoisobutyrate
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
highly specific for 5-L-glutamyl peptides
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
preferred substrates: 5-L-glutamyl-5-L-glutamyl-amino acids
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with: 5-glutamyl-4-nitroanilide
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
-
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
-
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
-
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with L-glutamine
-
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with: glutathione, i.e. gamma-L-glutamyl-L-cysteinylglycine
-
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with L-glutamyl-L-glutamyl-L-phenylalanine and L-glutamyl-L-glutamyl-1-naphthylamide
-
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with: alpha-L-glutamyl-glycine, alpha-L-glutamyl-L-alanine, alpha-L-glutamyl-L-tyrosine, alpha-L-glutamyl-2-naphthylamide, alpha-L-glutamyl-4-methoxy-2-beta-naphthylamide
-
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
-
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
-
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with LD-, DD- and DL-isomers of 5-L-glutamyl-5-L-glutamyl-4-nitroanilide
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with L-glutamine
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with: glutathione, i.e. gamma-L-glutamyl-L-cysteinylglycine
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with L-glutamyl-beta-alanine, L-glutamyl-3-aminoisobutyrate
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with D-glutamyl-2-aminobutyrate, L-(3-methyl)glutamyl-2-aminobutyrate, 3-aminoglutaryl-2-aminobutyrate, L-5-(N-methyl)glutamyl-2-aminobutyrate, 5-(5-methyl)glutamyl-2-aminobutyrate
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with: 5-glutamyl-4-nitroanilide
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
-
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
-
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
-
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
stereospecific
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
preferred substrates: 5-L-glutamyl-5-L-glutamyl-amino acids
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
preferred substrates: 5-L-glutamyl-5-L-glutamyl-amino acids
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
preferred substrates: 5-L-glutamyl-5-L-glutamyl-amino acids
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
-
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
stereospecific
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with L-glutamine
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
highly specific for 5-L-glutamyl peptides
-
?
5-L-glutamyl-L-aspartate
5-oxoproline + L-aspartate
-
-
-
?
5-L-glutamyl-L-aspartate
5-oxoproline + L-aspartate
-
-
-
?
5-L-glutamyl-L-cysteine
5-oxoproline + L-cysteine
-
-
-
?
5-L-glutamyl-L-cysteine
5-oxoproline + L-cysteine
-
-
-
-
?
5-L-glutamyl-L-glutamate
5-oxoproline + L-glutamate
-
-
-
?
5-L-glutamyl-L-glutamate
5-oxoproline + L-glutamate
-
-
-
?
5-L-glutamyl-L-glutamate
5-oxoproline + L-glutamate
-
-
-
?
5-L-glutamyl-L-glutamate
5-oxoproline + L-glutamate
-
poor substrate
-
?
5-L-glutamyl-L-glutamate
5-oxoproline + L-glutamate
-
-
-
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
-
-
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
-
-
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
-
-
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
-
-
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
-
-
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
best substrate
-
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
best substrate
-
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
best substrate
-
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
best substrate
-
?
5-L-glutamyl-L-leucine
5-oxoproline + L-leucine
-
-
-
?
5-L-glutamyl-L-leucine
5-oxoproline + L-leucine
-
-
-
?
5-L-glutamyl-L-leucine
5-oxoproline + L-leucine
-
-
-
?
5-L-glutamyl-L-leucine
5-oxoproline + L-leucine
-
very low activity
-
?
5-L-glutamyl-L-leucine
5-oxoproline + L-leucine
-
poor substrate
-
?
5-L-glutamyl-L-methionine
5-oxoproline + L-methionine
-
70% as effective as L-glutamyl-L-phenylalanine
-
-
?
5-L-glutamyl-L-methionine
5-oxoproline + L-methionine
-
highly specific for, no activity with D-glutamyl-L-methionine
-
?
5-L-glutamyl-L-methionine
5-oxoproline + L-methionine
-
-
-
-
?
5-L-glutamyl-L-methionine
5-oxoproline + L-methionine
-
best substrate
-
-
?
5-L-glutamyl-L-methionine
5-oxoproline + L-methionine
-
best substrate
-
-
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
poor substrate
-
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
poor substrate
-
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
best substrate
-
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
poor substrate
-
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
poor substrate
-
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
poor substrate
-
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
poor substrate
-
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
poor substrate
-
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
poor substrate
-
?
5-L-glutamyl-L-valine
5-oxoproline + L-valine
-
10% as effective as 5-L-glutamyl-L-phenylalanine
-
?
5-L-glutamyl-L-valine
5-oxoproline + L-valine
-
very low activity
-
?
5-L-glutamyl-L-valine
5-oxoproline + L-valine
-
poor substrate
-
?
5-L-glutamyl-S-methyl-L-cysteine
5-oxoproline + S-methyl-L-cysteine
-
-
-
?
5-L-glutamyl-S-methyl-L-cysteine
5-oxoproline + S-methyl-L-cysteine
-
-
-
?
5-L-glutamyl-S-methyl-L-cysteine
5-oxoproline + S-methyl-L-cysteine
-
-
-
?
5-L-glutamyl-S-methyl-L-cysteine
5-oxoproline + S-methyl-L-cysteine
-
-
-
?
gamma-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
enzyme of L-glutamyl-cycle
-
?
gamma-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
involved in sclerotization process of white pupae
-
?
glutathione
5-oxoproline + L-Cys-Gly
-
-
-
-
?
glutathione
5-oxoproline + L-Cys-Gly
-
-
-
-
?
Nepsilon-(5-L-glutamyl)-L-lysine
5-oxoproline + L-lysine
-
-
-
?
Nepsilon-(5-L-glutamyl)-L-lysine
5-oxoproline + L-lysine
-
-
-
-
?
Nepsilon-(5-L-glutamyl)-L-lysine
5-oxoproline + L-lysine
-
-
-
?
additional information
?
-
-
no significant activity towards gamma-Glu-Cys
-
-
?
additional information
?
-
-
N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization
-
-
?
additional information
?
-
-
N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization
-
-
?
additional information
?
-
-
no activity with L-Glu-4-nitroanilide
-
-
?
additional information
?
-
-
the enzyme does not act on L-glutamine, alpha-(5-L-glutamyl)-L-lysine, 5-L-glutamyl-L-methionine, or 5-L-glutamyl-L-glutamine
-
-
?
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Steinkamp, R.; Schweihofen, B.; Rennenberg, H.
gamma-Glutamylcyclotransferase in tobacco suspension cultures: catalytic properties and subcellular localization
Physiol. Plant.
69
499-503
1987
Nicotiana tabacum
-
brenda
Orlowski, M.; Richman, P.G.; Meister, A.
Isolation and properties of gamma-L-glutamylcyclotransferase from human brain
Biochemistry
8
1048-1055
1969
Ovis aries, Homo sapiens
brenda
Board, P.G.; Moore, K.A.; Smith, J.E.
Purification and properties of gamma-glutamylcyclotransferase from human erythrocytes
Biochem. J.
173
427-431
1978
Homo sapiens
brenda
York, M.J.; Kuchel, P.W.; Chapman, B.E.
A proton nuclear magnetic resonance study of gamma-glutamyl-amino acid cyclotransferase in human erythrocytes
J. Biol. Chem.
259
15085-15088
1984
Homo sapiens
brenda
Orlowski, M.; Meister, A.
gamma-Glutamyl cyclotransferase. Distribution, isozymic forms, and specificity
J. Biol. Chem.
248
2836-2844
1973
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Meister, A.
gamma-Glutamylcyclotransferase from rat kidney
Methods Enzymol.
113
428-445
1981
Mus musculus, Rattus norvegicus
-
brenda
Taniguchi, N.; Meister, A.
gamma-Glutamyl cyclotransferase from rat kidney. Sulfhydryl groups and isolation of a stable form of the enzyme
J. Biol. Chem.
253
1799-1806
1978
Rattus norvegicus, Rattus norvegicus Holtzman
brenda
Bridges, R.J.; Griffith, O.W.; Meister, A.
L-gamma-(threo-beta-methyl)glutamyl-L-alpha-aminobutyrate, a selective substrate of alpha-glutamyl cyclotransferase
J. Biol. Chem.
255
10787-10792
1980
Ovis aries, Mus musculus
brenda
Orlowski, M.; Meister, A.
Enzymology of pyrrolidone carboxylic acid
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
4
123-151
1971
Cavia porcellus, Ovis aries, Homo sapiens, Mus musculus, Rattus norvegicus
-
brenda
Szweczuk, A.; Connell, G.E.
Specificity of gamma-glutamyl cyclotransferase
Can. J. Biochem.
53
706-712
1975
Homo sapiens, Rattus norvegicus, Sus scrofa
brenda
Griffith, O.W.; Meister, A.
Selective inhibition of gamma-glutamyl-cycle enzymes by substrate analogs
Proc. Natl. Acad. Sci. USA
74
3330-3334
1977
Ovis aries
brenda
York, M.J.; Crossley, M.J.; Hyslop, S.J.; Fisher, M.L.; Kuchel, P.W.
gamma-Glutamylcyclotransferase: inhibition by D-beta-aminoglutaryl-L-alanine and analysis of the solvent kinetic isotope effect
Eur. J. Biochem.
184
97-101
1989
Homo sapiens
brenda
Bodnaryk, R.P.; McGirr, L.
Purification, properties and function of a unique gamma-glutamyl cyclotransferase from the housefly, Musca domestica
Biochim. Biophys. Acta
315
352-362
1973
Musca domestica
-
brenda
Korotkina, R.N.; Matskevich, G.N.; Devlikanova, A.S.; Vishnevskii, A.A.; Kunitsyn, A.G.; Karelin, A.A.
Activity of glutathione-metabolizing and antioxidant enzymes in malignant and benign tumors of human lungs
Bull. Exp. Biol. Med.
133
606-608
2002
Homo sapiens
brenda
Danson, J.W.; Trawick, M.L.; Cooper, A.J.
Spectrophotometric assays for L-lysine alpha-oxidase and gamma-glutamylamine cyclotransferase
Anal. Biochem.
303
120-130
2002
Bos taurus, Rattus norvegicus
brenda
Schilling, S.; Hoffmann, T.; Manhart, S.; Hoffmann, M.; Demuth, H.U.
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions
FEBS Lett.
563
191-196
2004
Carica papaya, Homo sapiens
brenda
Ren, J.; Mao, Y.; Wang, G.; Wang, X.; Fan, C.; Wang, Z.; Li, J.
Enteral refeeding syndrome after long-term total parenteral nutrition
Chin. Med. J.
119
1856-1860
2006
Homo sapiens
brenda
Oakley, A.J.; Yamada, T.; Liu, D.; Coggan, M.; Clark, A.G.; Board, P.G.
The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle
J. Biol. Chem.
283
22031-22042
2008
Homo sapiens (O75223)
brenda
Ohkama-Ohtsu, N.; Oikawa, A.; Zhao, P.; Xiang, C.; Saito, K.; Oliver, D.J.
A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis
Plant Physiol.
148
1603-1613
2008
Arabidopsis thaliana
brenda
Oakley, A.J.; Coggan, M.; Board, P.G.
Identification and characterization of {gamma}-glutamylamine cyclotransferase: An enzyme responsible for {gamma}-glutamyl-{epsilon}-lysine catabolism
J. Biol. Chem.
285
9642-9648
2010
Homo sapiens (Q9BVM4)
brenda
Oda, K.; Makino, S.; Masuda, C.; Yoshiki, T.; Kitamura, Y.; Takata, K.; Yanagisawa, D.; Taniguchi, T.; Tooyama, I.
The mRNA distribution of C7orf24, a gamma-glutamyl cyclotransferase, in rat tissues
J. Histochem. Cytochem.
57
1121-1126
2009
Rattus norvegicus
brenda
Azumi, K.; Ikeda, Y.; Takeuchi, T.; Nomura, T.; Sabau, S.; Hamada, J.; Okada, F.; Hosokawa, M.; Yokosawa, H.
Localization and characterization of gamma-glutamyl cyclotransferase in cancer cells
Mol. Med. Rep.
2
385-391
2009
Rattus norvegicus, Homo sapiens (O75223), Homo sapiens
brenda
Bowser, T.E.; Trawick, M.L.
Probing the specificity of gamma-glutamylamine cyclotransferase: an enzyme involved in the metabolism of transglutaminase-catalyzed protein crosslinks
Amino Acids
44
143-150
2013
Oryctolagus cuniculus
brenda
Gromov, P.; Gromova, I.; Friis, E.; Timmermans-Wielenga, V.; Rank, F.; Simon, R.; Sauter, G.; Moreira, J.M.
Proteomic profiling of mammary carcinomas identifies C7orf24, a gamma-glutamyl cyclotransferase, as a potential cancer biomarker
J. Proteome Res.
9
3941-3953
2010
Homo sapiens
brenda
Shen, S.H.; Yu, N.; Liu, X.Y.; Tan, G.W.; Wang, Z.X.
Gamma-glutamylcyclotransferase promotes the growth of human glioma cells by activating Notch-Akt signaling
Biochem. Biophys. Res. Commun.
471
616-620
2016
Homo sapiens
brenda
Kumar, S.; Kaur, A.; Chattopadhyay, B.; Bachhawat, A.K.
Defining the cytosolic pathway of glutathione degradation in Arabidopsis thaliana: role of the ChaC/GCG family of gamma-glutamyl cyclotransferases as glutathione-degrading enzymes and AtLAP1 as the Cys-Gly peptidase
Biochem. J.
468
73-85
2015
Arabidopsis thaliana
brenda
Kageyama, S.; Hanada, E.; Ii, H.; Tomita, K.; Yoshiki, T.; Kawauchi, A.
gamma-Glutamylcyclotransferase: A novel target molecule for cancer diagnosis and treatment
BioMed Res. Int.
2015
345219
2015
Homo sapiens
brenda
Yoshiya, T.; Tsuda, S.; Mochizuki, M.; Hidaka, K.; Tsuda, Y.; Kiso, Y.; Kageyama, S.; Ii, H.; Yoshiki, T.; Nishiuchi, Y.
A fluorogenic probe for gamma-glutamyl cyclotransferase: application of an enzyme-triggered O-to-N acyl migration-type reaction
ChemBioChem
14
2110-2113
2013
Homo sapiens
brenda
Fujiwara, S.; Kawazoe, T.; Ohnishi, K.; Kitagawa, T.; Popa, C.; Valls, M.; Genin, S.; Nakamura, K.; Kuramitsu, Y.; Tanaka, N.; Tabuchi, M.
RipAY, a plant pathogen effector protein exhibits robust gamma-glutamyl cyclotransferase activity when stimulated by eukaryotic thioredoxins
J. Biol. Chem.
291
6813-6830
2016
Ralstonia solanacearum
brenda
Paulose, B.; Chhikara, S.; Coomey, J.; Jung, H.I.; Vatamaniuk, O.; Dhankher, O.P.
A gamma-glutamyl cyclotransferase protects Arabidopsis plants from heavy metal toxicity by recycling glutamate to maintain glutathione homeostasis
Plant Cell
25
4580-4595
2013
Arabidopsis thaliana
brenda
Dong, J.; Zhou, Y.; Liao, Z.; Huang, Q.; Feng, S.; Li, Y.
Role of gamma-glutamyl cyclotransferase as a therapeutic target for colorectal cancer based on the lentivirus-mediated system
Anticancer Drugs
27
1011-1020
2016
Homo sapiens (O75223)
brenda
Yoshiya, T.; Ii, H.; Tsuda, S.; Mochizuki, M.; Kageyama, S.; Yoshiki, T.
Design of fluorogenic probes and fluorescent-tagged inhibitors for gamma-glutamyl cyclotransferase
J. Pept. Sci.
23
618-623
2017
Homo sapiens (O75223)
brenda