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Information on EC 4.3.2.9 - gamma-glutamylcyclotransferase
for references in articles please use BRENDA:EC4.3.2.9
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EC Tree 4 Lyases
4.3 Carbon-nitrogen lyases
4.3.2 Amidine-lyases
4.3.2.9 gamma-glutamylcyclotransferase
IUBMB Comments
The enzyme, found in animals and plants, acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the α-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
- 4.3.2.9
-
2.3.2.2
-
smoking
- gamma-gt
- triglyceride
- gsh
-
alt
-
drinker
-
confound
- glycylglycine
-
carbohydrate-deficient
- bilirubin
-
c-reactive
-
middle-aged
-
hepatobiliary
-
all-cause
-
coffee
-
waist
- 5-oxoproline
-
transpeptidation
-
abstinence
-
corpuscular
-
gamma-glutamyl-transferase
-
glutamyltransferase
- acivicin
-
abstain
- medicine
Reaction Schemes
showSynonyms
gamma-glutamyl cyclotransferase, c7orf24, ripay, gamma-glutamylcyclotransferase, ggct2;1, ggact, protein c7orf24, c7orf24 protein, gamma-glutamyl-amino acid cyclotransferase, a2ld1, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C7orf24
cyclotransferase, gamma-glutamyl
-
-
-
-
EC 2.3.2.4
-
-
formerly
-
gamma-glutamyl cyclotransferase
gamma-glutamyl-amino acid cyclotransferase
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-
-
-
gamma-L-glutamylcyclotransferase
-
-
-
-
GGACT
GGCT
L-glutamic cyclase
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-
-
-
protein C7orf24
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
alpha-(gamma-L-glutamyl)-L-amino acid = alpha-L-amino acid + 5-oxo-L-proline
mechanism
-
alpha-(gamma-L-glutamyl)-L-amino acid = alpha-L-amino acid + 5-oxo-L-proline
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
aminoacyl group transfer
aminoacyl group transfer
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-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
gamma-glutamyl cycle
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SYSTEMATIC NAME
IUBMB Comments
alpha-(gamma-L-glutamyl)-L-amino-acid gamma-glutamyl cyclotransferase (5-oxo-L-proline producing)
The enzyme, found in animals and plants, acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
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CAS REGISTRY NUMBER
COMMENTARY
9045-44-7
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(gamma-L-glutamyl)-L-serine
5-oxoproline + L-serine
-
Substrates: -
Products: -
Products: -
?
2-amino-5-(butan-2-ylamino)-5-oxopentanoic acid
DL-proline + (S)-butan-2-amine
-
Substrates: -
Products: -
Products: -
?
2-amino-5-(cyclohexylamino)-5-oxopentanoic acid
DL-proline + cyclohexylamine
-
Substrates: -
Products: -
Products: -
?
2-amino-5-(cyclopropylamino)-5-oxopentanoic acid
DL-proline + cyclopropylamine
-
Substrates: -
Products: -
Products: -
?
2-amino-5-(tert-butylamino)-5-oxopentanoic acid
DL-proline + tert-butylamine
-
Substrates: -
Products: -
Products: -
?
2-amino-5-oxo-5-(propan-2-ylamino)pentanoic acid
DL-proline + propan-2-amine
-
Substrates: -
Products: -
Products: -
?
2-amino-5-[(2-methylbutyl)amino]-5-oxopentanoic acid
DL-proline + (RS)-2-methylbutan-1-amine
-
Substrates: -
Products: -
Products: -
?
2-amino-5-[(2S)-butan-2-ylamino]-5-oxopentanoic acid
DL-proline + (S)-butan-2-amine
-
Substrates: -
Products: -
Products: -
?
2-amino-5-[[(2S)-2-methylbutyl]amino]-5-oxopentanoic acid
DL-proline + (2S)-2-methylbutan-1-amine
-
Substrates: -
Products: -
Products: -
?
2-N-(5-L-glutamyl)L-lysine
5-oxoproline + L-lysine
-
Substrates: -
Products: -
Products: -
?
5-(4-methyl)glutamyl-L-2-aminobutyrate
3-methyl-5-oxoproline + L-alpha-aminobutyrate
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Substrates: substrate analog, 90% as effective as 5-glutamyl-L-2-aminobutyrate
Products: -
Products: -
?
5-L-(threo-2-methyl)glutamyl-L-alpha-aminobutyrate
?
-
Substrates: -
Products: -
Products: -
?
5-L-(threo-4-methyl)glutamyl-L-2-aminobutyrate
3-methyl-5-oxoproline + L-alpha-aminobutyrate
5-L-glutamyl-(+)-3-aminobutyric acid
5-oxoproline + (+)-3-aminbutyric acid
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-(+)-3-aminoisobutyric acid
5-oxoproline + (+)-3-aminoisobutyric acid
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-glutamate
5-oxoproline + 5-L-glutamyl-L-glutamate
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-leucine
5-oxoproline + 5-L-glutamyl-L-leucine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-lysine
5-oxoproline + 5-L-glutamyl-L-lysine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-phenylalanine
5-oxoproline + 5-L-glutamyl-L-phenylalanine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-proline
5-oxoproline + 5-L-glutamyl-L-proline
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-tyrosine
5-oxoproline + 5-L-glutamyl-L-tyrosine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-valine
5-oxoproline + 5-L-glutamyl-L-valine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-anilide
5-oxoproline + aniline
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-benzylamine
5-oxoproline + benzylamine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-beta-alanine
5-oxoproline + beta-alanine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-beta-phenethylamine
5-oxoproline + beta-phenethylamine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-cyclopentylamine
5-oxoproline + cyclopentylamine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-cysteine
5-oxoproline + L-cysteine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-ethylamine
5-oxoproline + ethylamine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
5-L-glutamyl-L-6-N-benzyloxycarbonyl-L-lysine
5-oxoproline + L-6-N-benzyloxycarbonyl-L-lysine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-aspartate
5-oxoproline + L-aspartate
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-isoleucine
5-oxoproline + L-isoleucine
-
Substrates: very low activity
Products: -
Products: -
?
5-L-glutamyl-L-proline
5-oxoproline + L-proline
-
Substrates: very low activity
Products: -
Products: -
?
5-L-glutamyl-L-tyrosine
5-oxoproline + L-tyrosine
-
Substrates: very low activity
Products: -
Products: -
?
5-L-glutamyl-methylamine
5-oxoproline + methylamine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-n-butylamine
5-oxoproline + butylamine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-n-propylamine
5-oxoproline + propylamine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-neohexylamine
5-oxoproline + neohexylamine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-neopentylamine
5-oxoproline + neopentylamine
-
Substrates: -
Products: -
Products: -
?
alpha-N-(gamma-L-glutamyl)-L-lysine
L-lysine + 5-oxo-L-proline
-
Substrates: -
Products: -
Products: -
?
D-gamma-glutamyl-O-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]-L-serine
5-oxoproline + O-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]-L-serine
-
Substrates: -
Products: -
Products: -
?
gamma-glutamyl-Cys + H2O
5-oxoproline + L-cysteine
-
Substrates: assay at 30Ā°C, pH 8.0, 60 min, 48 microl substrate, reaction stopped with 6 microl HCl
Products: -
Products: -
?
gamma-glutamyl-L-alanine
5-oxoproline + alanine
Substrates: -
Products: -
Products: -
?
gamma-L-Glu-epsilon-N-benzyloxycarbonyl-L-Lys
epsilon-N-benzyloxycarbonyl-L-Lys + 5-oxo-L-proline
Substrates: -
Products: -
Products: -
?
Gln-2-naphthylamide
pyroglutamyl-2-naphthylamide + NH3
-
Substrates: -
Products: -
Products: -
?
L-2-amino-3-(3-n-butylureido)-propionic acid
?
-
Substrates: -
Products: -
Products: -
?
L-gamma-glutamyl-L-epsilon-lysine
5-oxoproline + L-lysine
Substrates: -
Products: -
Products: -
?
L-gamma-glutamyl-O-[(4-methylumbelliferyl)carbonyl]-L-serine
(2S)-2-amino-3-([[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]oxy)propanoic acid + 5-oxo-L-proline
Substrates: fluorogenic probe
Products: -
Products: -
?
N5-((S)-1-carboxy-3-(ethyl(((3-oxo-3H-phenoxazin-7-yl)oxy)carbonyl)amino)propyl)-L-glutamine
(2S)-2-amino-4-(ethyl[[(3-oxo-3H-phenoxazin-7-yl)oxy]carbonyl]amino)butanoic acid + 5-oxo-L-proline
Substrates: fluorogenic probe
Products: -
Products: -
?
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: -
Products: -
Products: -
?
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
Substrates: -
Products: -
Products: -
?
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
Substrates: -
Products: -
Products: -
?
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: -
Products: -
Products: -
?
5-L-(threo-4-methyl)glutamyl-L-2-aminobutyrate
3-methyl-5-oxoproline + L-alpha-aminobutyrate
-
Substrates: model substrate, in vivo and in vitro
Products: -
Products: -
?
5-L-(threo-4-methyl)glutamyl-L-2-aminobutyrate
3-methyl-5-oxoproline + L-alpha-aminobutyrate
-
Substrates: -
Products: -
Products: -
?
5-L-(threo-4-methyl)glutamyl-L-2-aminobutyrate
3-methyl-5-oxoproline + L-alpha-aminobutyrate
-
Substrates: model substrate, in vivo and in vitro
Products: -
Products: -
?
5-L-glutamyl-1-naphthylamide
5-oxoproline + naphthylamine
-
Substrates: best substrate
Products: -
Products: -
?
5-L-glutamyl-1-naphthylamide
5-oxoproline + naphthylamine
-
Substrates: best substrate
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-4-nitroanilide
5-oxoproline + 5-L-glutamyl-4-nitroanilide
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-4-nitroanilide
5-oxoproline + 5-L-glutamyl-4-nitroanilide
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-glycine
5-oxoproline + 5-L-glutamyl-glycine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-glycine
5-oxoproline + 5-L-glutamyl-glycine
-
Substrates: high activity
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-glycine
5-oxoproline + 5-L-glutamyl-glycine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-alanine
5-oxoproline + 5-L-glutamyl-L-alanine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-alanine
5-oxoproline + 5-L-glutamyl-L-alanine
-
Substrates: high activity
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-alanine
5-oxoproline + 5-L-glutamyl-L-alanine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-amino acid
5-oxoproline + 5-L-glutamyl-L-amino acid
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-amino acid
5-oxoproline + 5-L-glutamyl-L-amino acid
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-glutamine
5-oxoproline + 5-L-glutamyl-L-glutamine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-glutamine
5-oxoproline + 5-L-glutamyl-L-glutamine
-
Substrates: high activity
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-glutamine
5-oxoproline + 5-L-glutamyl-L-glutamine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-threonine
5-oxoproline + 5-L-glutamyl-L-threonine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-5-L-glutamyl-L-threonine
5-oxoproline + 5-L-glutamyl-L-threonine
-
Substrates: high activity
Products: -
Products: -
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
Substrates: poor substrate
Products: -
Products: -
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
Substrates: poor substrate
Products: -
Products: -
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
Substrates: best substrate
Products: -
Products: -
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
Substrates: 25% as effective as 5-L-glutamyl-L-phenylalanine
Products: -
Products: -
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
Substrates: no activity with D-glutamyl-isomer
Products: -
Products: -
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
Substrates: best substrate
Products: -
Products: -
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-alanine
5-oxoproline + L-alanine
-
Substrates: low activity compared to glutathione
Products: -
Products: -
?
5-L-glutamyl-L-alanine
5-oxoproline + L-alanine
-
Substrates: low activity compared to glutathione
Products: -
Products: -
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: -
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: stereospecific
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with LD-, DD- and DL-isomers of 5-L-glutamyl-5-L-glutamyl-4-nitroanilide
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with L-glutamine
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with: glutathione, i.e. gamma-L-glutamyl-L-cysteinylglycine
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with L-glutamyl-beta-alanine, L-glutamyl-3-aminoisobutyrate
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: highly specific for 5-L-glutamyl peptides
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: preferred substrates: 5-L-glutamyl-5-L-glutamyl-amino acids
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with: 5-glutamyl-4-nitroanilide
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: -
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with L-glutamine
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with: glutathione, i.e. gamma-L-glutamyl-L-cysteinylglycine
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with L-glutamyl-L-glutamyl-L-phenylalanine and L-glutamyl-L-glutamyl-1-naphthylamide
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with: alpha-L-glutamyl-glycine, alpha-L-glutamyl-L-alanine, alpha-L-glutamyl-L-tyrosine, alpha-L-glutamyl-2-naphthylamide, alpha-L-glutamyl-4-methoxy-2-beta-naphthylamide
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: -
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: -
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with LD-, DD- and DL-isomers of 5-L-glutamyl-5-L-glutamyl-4-nitroanilide
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with L-glutamine
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with: glutathione, i.e. gamma-L-glutamyl-L-cysteinylglycine
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with L-glutamyl-beta-alanine, L-glutamyl-3-aminoisobutyrate
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with D-glutamyl-2-aminobutyrate, L-(3-methyl)glutamyl-2-aminobutyrate, 3-aminoglutaryl-2-aminobutyrate, L-5-(N-methyl)glutamyl-2-aminobutyrate, 5-(5-methyl)glutamyl-2-aminobutyrate
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with: 5-glutamyl-4-nitroanilide
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: -
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: stereospecific
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: preferred substrates: 5-L-glutamyl-5-L-glutamyl-amino acids
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: preferred substrates: 5-L-glutamyl-5-L-glutamyl-amino acids
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: preferred substrates: 5-L-glutamyl-5-L-glutamyl-amino acids
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: -
Products: i.e. 2-pyrrolidone-5-carboxylic acid
Products: i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: stereospecific
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: no activity with L-glutamine
Products: -
Products: -
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: highly specific for 5-L-glutamyl peptides
Products: -
Products: -
?
5-L-glutamyl-L-cysteine
5-oxoproline + L-cysteine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-cysteine
5-oxoproline + L-cysteine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-glutamate
5-oxoproline + L-glutamate
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-glutamate
5-oxoproline + L-glutamate
-
Substrates: poor substrate
Products: -
Products: -
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
Substrates: best substrate
Products: -
Products: -
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
Substrates: best substrate
Products: -
Products: -
?
5-L-glutamyl-L-leucine
5-oxoproline + L-leucine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-leucine
5-oxoproline + L-leucine
-
Substrates: very low activity
Products: -
Products: -
?
5-L-glutamyl-L-leucine
5-oxoproline + L-leucine
-
Substrates: poor substrate
Products: -
Products: -
?
5-L-glutamyl-L-methionine
5-oxoproline + L-methionine
-
Substrates: 70% as effective as L-glutamyl-L-phenylalanine
Products: -
Products: -
?
5-L-glutamyl-L-methionine
5-oxoproline + L-methionine
-
Substrates: highly specific for, no activity with D-glutamyl-L-methionine
Products: -
Products: -
?
5-L-glutamyl-L-methionine
5-oxoproline + L-methionine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-L-methionine
5-oxoproline + L-methionine
-
Substrates: best substrate
Products: -
Products: -
?
5-L-glutamyl-L-methionine
5-oxoproline + L-methionine
-
Substrates: best substrate
Products: -
Products: -
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
Substrates: poor substrate
Products: -
Products: -
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
Substrates: best substrate
Products: -
Products: -
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
Substrates: poor substrate
Products: -
Products: -
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
Substrates: poor substrate
Products: -
Products: -
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
Substrates: poor substrate
Products: -
Products: -
?
5-L-glutamyl-L-valine
5-oxoproline + L-valine
-
Substrates: 10% as effective as 5-L-glutamyl-L-phenylalanine
Products: -
Products: -
?
5-L-glutamyl-L-valine
5-oxoproline + L-valine
-
Substrates: very low activity
Products: -
Products: -
?
5-L-glutamyl-L-valine
5-oxoproline + L-valine
-
Substrates: poor substrate
Products: -
Products: -
?
5-L-glutamyl-S-methyl-L-cysteine
5-oxoproline + S-methyl-L-cysteine
-
Substrates: -
Products: -
Products: -
?
5-L-glutamyl-S-methyl-L-cysteine
5-oxoproline + S-methyl-L-cysteine
-
Substrates: -
Products: -
Products: -
?
gamma-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: enzyme of L-glutamyl-cycle
Products: -
Products: -
?
gamma-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: involved in sclerotization process of white pupae
Products: -
Products: -
?
glutathione
5-oxoproline + L-Cys-Gly
-
Substrates: -
Products: -
Products: -
?
Nepsilon-(5-L-glutamyl)-L-lysine
5-oxoproline + L-lysine
-
Substrates: -
Products: -
Products: -
?
Nepsilon-(5-L-glutamyl)-L-lysine
5-oxoproline + L-lysine
-
Substrates: -
Products: -
Products: -
?
Nepsilon-(5-L-glutamyl)-L-lysine
5-oxoproline + L-lysine
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: no significant activity towards gamma-Glu-Cys
Products: -
Products: -
?
additional information
?
-
-
Substrates: N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization
Products: -
Products: -
?
additional information
?
-
-
Substrates: N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with L-Glu-4-nitroanilide
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme does not act on L-glutamine, alpha-(5-L-glutamyl)-L-lysine, 5-L-glutamyl-L-methionine, or 5-L-glutamyl-L-glutamine
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: -
Products: -
Products: -
?
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
Substrates: -
Products: -
Products: -
?
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
Substrates: -
Products: -
Products: -
?
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: -
Products: -
Products: -
?
gamma-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: enzyme of L-glutamyl-cycle
Products: -
Products: -
?
gamma-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
Substrates: involved in sclerotization process of white pupae
Products: -
Products: -
?
additional information
?
-
-
Substrates: N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization
Products: -
Products: -
?
additional information
?
-
-
Substrates: N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE