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Information on EC 1.14.19.17 - sphingolipid 4-desaturase

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EC Tree
IUBMB Comments
The enzyme, which has been characterized from plants, fungi, and mammals, generates a trans double bond at position 4 of sphinganine bases in sphingolipids . The preferred substrate is dihydroceramide, but the enzyme is also active with dihydroglucosylceramide . Unlike EC 1.14.19.29, sphingolipid 8-desaturase, this enzyme does not contain an integral cytochrome b5 domain and requires an external cytochrome b5 . The product serves as an important signalling molecules in mammals and is required for spermatide differentiation .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
degenerative spermatocyte desaturase, DegS, Degs1, DEGS2, dehydroceramide desaturase, DELTA4 desaturase, DELTA4DES, DES-1, DES1, DES2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O
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