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Information on EC 3.1.4.4 - phospholipase D
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EC Tree
3.1.4.4 phospholipase DIUBMB Comments
Also acts on other phosphatidyl esters.
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Word Map
- 3.1.4.4
-
phosphatidic
- diacylglycerol
- pkc
-
liposomal
- doxorubicin
- agonist
-
pegylated
-
phorbol
- phospholipases
-
transphosphatidylation
- 12-myristate
-
adp-ribosylation
- 13-acetate
- pertussis
-
phosphohydrolase
-
arachidonic
- propranolol
- phosphoinositide
-
gtp-binding
- fmlp
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prelabeled
- anandamide
- rhoa
- 1-butanol
-
endocannabinoids
- staurosporine
-
lysophosphatidic
- pc-plc
-
phosphatidylcholine-specific
-
latissimus
- diglyceride
- pkcalpha
-
phosphatidylinositol-specific
- pseudotuberculosis
- 1,2-diacylglycerol
- arf6
- cannabinoids
-
fmet-leu-phe
-
listening
-
fmlp-stimulated
-
platinum-resistant
- analysis
-
phosphoinositide-specific
- gtpgammas
- synthesis
-
3hcholine
-
hand-foot
-
platinum-sensitive
-
fmlp-induced
- lymphadenitis
- medicine
-
ptdins4,5p2
- molecular biology
- 5-kinase
- agriculture
- biotechnology
The enzyme appears in viruses and cellular organisms
Synonyms
pld, phospholipase d, nape-pld, phospholipase d1, dermonecrotic toxin, phospholipase d2, pc-pld, pldalpha, rpld1, spo14, 
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REACTION 
REACTION DIAGRAM
COMMENTARY 
ORGANISM
UNIPROT
LITERATURE
a phosphatidylcholine + H2O = choline + a phosphatidate
acts also on other phosphatidyl esters
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a phosphatidylcholine + H2O = choline + a phosphatidate
mechanism, structural requirements of substrate
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a phosphatidylcholine + H2O = choline + a phosphatidate
catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview
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a phosphatidylcholine + H2O = choline + a phosphatidate
catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview
-
a phosphatidylcholine + H2O = choline + a phosphatidate
catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview
-
a phosphatidylcholine + H2O = choline + a phosphatidate
catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview
-
a phosphatidylcholine + H2O = choline + a phosphatidate
catalytic mechanism, PLD uses a ping-pong type of reaction through the formation of a covalent phosphatidyl-enzyme intermediate, structure-function relationship, and substrate recognition and specificity, overview
a phosphatidylcholine + H2O = choline + a phosphatidate
general reaction mechanism through an SN2-type associative pathway for phospholipase D-catalyzed hydrolysis of phospholipids, the formation of the phosphohistidine intermediate involves the conserved histidine 167 of the N-terminal HKD domain, overview
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a phosphatidylcholine + H2O = choline + a phosphatidate
catalytic mechanisms of PLD isozymes, overview
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a phosphatidylcholine + H2O = choline + a phosphatidate
mode of substrate binding, the catalysis proceeds via two-step reaction with the formation of phosphatidyl-enzyme intermediate. Both of the two catalytic His residues are critical in the reaction course, where one acts as a nucleophile, while the other functions as a general acid/base, reaction cycle overview
-
a phosphatidylcholine + H2O = choline + a phosphatidate
mode of substrate binding, the catalysis proceeds via two-step reaction with the formation of phosphatidyl-enzyme intermediate. Both of the two catalytic His residues are critical in the reaction course, where one acts as a nucleophile, while the other functions as a general acid/base, reaction cycle overview
a phosphatidylcholine + H2O = choline + a phosphatidate
the catalysis proceeds via two-step reaction with the formation of phosphatidyl-enzyme intermediate. Both of the two catalytic His residues are critical in the reaction course, where one acts as a nucleophile, while the other functions as a general acid/base, reaction cycle overview
-
a phosphatidylcholine + H2O = choline + a phosphatidate
the catalysis proceeds via two-step reaction with the formation of phosphatidyl-enzyme intermediate. Both of the two catalytic His residues are critical in the reaction course, where one acts as a nucleophile, while the other functions as a general acid/base, reaction cycle overview
-
a phosphatidylcholine + H2O = choline + a phosphatidate
the catalysis proceeds via two-step reaction with the formation of phosphatidyl-enzyme intermediate. Both of the two catalytic His residues are critical in the reaction course, where one acts as a nucleophile, while the other functions as a general acid/base, reaction cycle overview
a phosphatidylcholine + H2O = choline + a phosphatidate
the catalysis proceeds via two-step reaction with the formation of phosphatidyl-enzyme intermediate. Both of the two catalytic His residues are critical in the reaction course, where one acts as a nucleophile, while the other functions as a general acid/base, reaction cycle overview
a phosphatidylcholine + H2O = choline + a phosphatidate
the catalysis proceeds via two-step reaction with the formation of phosphatidyl-enzyme intermediate. Both of the two catalytic His residues are critical in the reaction course, where one acts as a nucleophile, while the other functions as a general acid/base, reaction cycle overview
a phosphatidylcholine + H2O = choline + a phosphatidate
the catalysis proceeds via two-step reaction with the formation of phosphatidyl-enzyme intermediate. Both of the two catalytic His residues are critical in the reaction course, where one acts as a nucleophile, while the other functions as a general acid/base, reaction cycle overview
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-
a phosphatidylcholine + H2O = choline + a phosphatidate
the catalysis proceeds via two-step reaction with the formation of phosphatidyl-enzyme intermediate. Both of the two catalytic His residues are critical in the reaction course, where one acts as a nucleophile, while the other functions as a general acid/base, reaction cycle overview
Actinomadura sp. 362
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a phosphatidylcholine + H2O = choline + a phosphatidate
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