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Literature summary for 3.4.21.B28 extracted from

  • Mentlein, R.; Hattermann, K.; Hemion, C.; Jungbluth, A.; Held-Feindt, J.
    Expression and role of the cell surface protease seprase/fibroblast activation protein-alpha (FAP-alpha) in astroglial tumors (2011), Biol. Chem., 392, 199-207.
    View publication on PubMed
Search for more literature for 3.4.21.B28

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha2-antiplasmin + H2O Homo sapiens
-
 ?
-
 ?
Gelatin + H2O Homo sapiens
-
 ?
-
 ?
pre-digested collagen + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocytoma cell
-
 Homo sapiens
-
astroglial tumor cell
-
 Homo sapiens
-
glioblastoma cell
-
 Homo sapiens
-
glioblastoma cell glioma stem-like cell, isolated from a solid glioblastoma in a long term culture, low expression Homo sapiens
-
glioma cell
-
 Homo sapiens
-
U-118MG cell
-
 Homo sapiens
-
U-138 cell
-
 Homo sapiens
-
U-343 MG-A cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha2-antiplasmin + H2O
-
 Homo sapiens ?
-
 ?
Gelatin + H2O
-
 Homo sapiens ?
-
 ?
additional information does not cleave native human collagens, fibronectin or laminin Homo sapiens ?
-
 ?
additional information FAP-alpha is an endopeptidase cleaving large protein with Gly(2)-Pro(1)-cleaving specificity Homo sapiens ?
-
 ?
pre-digested collagen + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
FAP-alpha
-
 Homo sapiens
fibroblast activation protein-alpha
-
 Homo sapiens
seprase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens FAP-alpha is considerably induced upon differentiation with 10% fetal calf serum, FAP-alpha is elevated in glioblastomas and increases upon tumor stem cell differentiation up

General Information

General Information Comment Organism
malfunction siRNA knockdown of FAP-alpha in a glioma cell line shows decreased invasion through brain extracellular matrix proteoglycan brevican and denatured collagen Homo sapiens