Information on EC 2.7.1.1 - hexokinase

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The expected taxonomic range for this enzyme is: Archaea, Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
2.7.1.1
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RECOMMENDED NAME
GeneOntology No.
hexokinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + D-hexose = ADP + D-hexose 6-phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
1,3-propanediol biosynthesis (engineered)
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Bifidobacterium shunt
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GDP-glucose biosynthesis
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glucose and glucose-1-phosphate degradation
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glycogen degradation I
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glycolysis III (from glucose)
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heterolactic fermentation
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sucrose biosynthesis II
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sucrose degradation III (sucrose invertase)
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trehalose degradation I (low osmolarity)
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trehalose degradation II (trehalase)
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trehalose degradation IV
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trehalose degradation V
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UDP-N-acetyl-D-galactosamine biosynthesis II
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glycolysis
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Glycolysis / Gluconeogenesis
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Fructose and mannose metabolism
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Galactose metabolism
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Starch and sucrose metabolism
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Amino sugar and nucleotide sugar metabolism
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Streptomycin biosynthesis
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Neomycin, kanamycin and gentamicin biosynthesis
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Metabolic pathways
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Biosynthesis of secondary metabolites
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Microbial metabolism in diverse environments
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
ATP:D-hexose 6-phosphotransferase
D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-51-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain ATCC 11414
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
2 isozymes HKI and HKII
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Manually annotated by BRENDA team
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Q56VN6
SwissProt
Manually annotated by BRENDA team
hexokinase I
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Manually annotated by BRENDA team
H, isoenzymes Hex I and Hex II
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Manually annotated by BRENDA team
recombinant
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
identical with Vinca rosea
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Manually annotated by BRENDA team
identical with Vinca rosea
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Samarkand, adult
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Manually annotated by BRENDA team
2 isoenzymes: HXK1 and HXK2
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Manually annotated by BRENDA team
2 isoenzymes: HXK1 and HXK2
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
type I, type II, type III, and type IV isozymes
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Manually annotated by BRENDA team
as a model of hepatocellular carcinoma
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Manually annotated by BRENDA team
and strain 124A
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Manually annotated by BRENDA team
and strain 124A
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Manually annotated by BRENDA team
no activity in Sus scrofa
sperm
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Manually annotated by BRENDA team
contains 11 hexokinase encoding genes
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
bullfrog, hexokinase I
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Saccharomyces cerevisiae G-517 / CECT 1317
3 isoenzymes PI, PII and glucokinase
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Manually annotated by BRENDA team
recombinant hexokinase
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Manually annotated by BRENDA team
2 isozymic forms
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Manually annotated by BRENDA team
hexokinase 1
SwissProt
Manually annotated by BRENDA team
hexokinase 2
SwissProt
Manually annotated by BRENDA team
starch-utilizing yeast, strain CBS819, i.e. ATCC2322, 2 isoenzymes: hexokinase and glucokinase
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
Kra 1, i.e. DSM 2078
SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
RH strain
GenBank
Manually annotated by BRENDA team
RH strain
GenBank
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
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HKI exclusively promotes glycolysis; HKII promotes glycolysis when bound to mitochondria. Promotes glycogen synthesis when located in the cytosol
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2'-dATP + D-glucose
2'-dADP + D-glucose 6-phosphate
show the reaction diagram
2-fluoro-2-deoxy-D-glucose + ATP
2-fluoro-2-deoxy-D-glucose 6-phosphate + ADP
show the reaction diagram
ATP + 1,5-anhydro-D-glucitol
ADP + 1,5-anhydro-D-glucitol 6-phosphate
show the reaction diagram
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weak
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?
ATP + 1-thio-D-glucose
ADP + 1-thio-D-glucose 6-phosphate
show the reaction diagram
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isoenzyme II, weak
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?
ATP + 2-deoxy-2-fluoro-D-glucose
ADP + 2-deoxy-2-fluoro-D-glucose 6-phosphate
show the reaction diagram
ATP + 2-deoxy-D-glucose
ADP + 2-deoxy-D-glucose 6-phosphate
show the reaction diagram
ATP + 3-deoxy-3-amino-D-glucose
ADP + 3-deoxy-3-amino-D-glucose 6-phosphate
show the reaction diagram
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isoenzyme II, weak
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?
ATP + 5-thio-D-glucose
ADP + 5-thio-D-glucose 6-phosphate
show the reaction diagram
ATP + D-allose
ADP + D-allose 6-phosphate
show the reaction diagram
ATP + D-fructose
?
show the reaction diagram
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?
ATP + D-fructose
ADP + D-fructose 6-phosphate
show the reaction diagram
ATP + D-galactose
?
show the reaction diagram
Q56VN6
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?
ATP + D-galactose
ADP + D-galactose 6-phosphate
show the reaction diagram
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?
ATP + D-glucosamine
ADP + D-glucosamine 6-phosphate
show the reaction diagram
ATP + D-glucose
ADP + D-glucose 6-phosphate
show the reaction diagram
ATP + D-maltose
?
show the reaction diagram
Q56VN6
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?
ATP + D-mannosamine
ADP + D-mannosamine 6-phosphate
show the reaction diagram
ATP + D-mannose
?
show the reaction diagram
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?
ATP + D-mannose
ADP + D-mannose 6-phosphate
show the reaction diagram
ATP + hexose
ADP + hexose 6-phosphate
show the reaction diagram
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?
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
show the reaction diagram
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?
CTP + D-glucose
CDP + D-glucose 6-phosphate
show the reaction diagram
D-fructose + ATP
ADP + D-fructose 6-phosphate
show the reaction diagram
D-fructose + ATP
D-fructose 6-phosphate + ADP
show the reaction diagram
D-glucosamine + ATP
ADP + D-glucosamine 6-phosphate
show the reaction diagram
D-glucose + ATP
ADP + D-glucose 6-phosphate
show the reaction diagram
D-glucose + ATP
D-glucose 6-phosphate + ADP
show the reaction diagram
D-mannose + ATP
ADP + D-mannose 6-phosphate
show the reaction diagram
GTP + D-glucose
GDP + D-glucose 6-phosphate
show the reaction diagram
hexose + ATP
ADP + hexose 6-phosphate
show the reaction diagram
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?
ITP + D-glucose
IDP + D-glucose 6-phosphate
show the reaction diagram
N-acetyl-D-glucosamine + ATP
ADP + N-acetyl-D-glucosamine 6-phosphate
show the reaction diagram
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erythrocyte enzyme, 32.6% of the activity with glucose
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?
TTP + D-glucose
TDP + D-glucose 6-phosphate
show the reaction diagram
UTP + D-glucose
UDP + D-glucose 6-phosphate
show the reaction diagram
additional information
?
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