Application | Comment | Organism |
---|---|---|
diagnostics | increased proportion of hexokinase II is used as a marker for brain tumors | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.032 | 0.034 | D-glucose | HK I, at 25°C, pH 7.4 | Bos taurus | |
0.039 | - |
D-glucose | HK I, at 25°C, pH 7.4 | Rattus norvegicus | |
0.055 | 0.062 | 2-fluoro-2-deoxy-D-glucose | HK I, at 25°C, pH 7.4 | Bos taurus | |
0.068 | 0.077 | 2-fluoro-2-deoxy-D-glucose | HK I, at 25°C, pH 7.4 | Rattus norvegicus | |
0.129 | 0.137 | D-glucose | HK II, at 25°C, pH 7.4 | Rattus norvegicus | |
0.152 | - |
2-deoxy-D-glucose | HKI, at 25°C, pH 7.4 | Bos taurus | |
0.166 | 0.174 | 2-fluoro-2-deoxy-D-glucose | HK II, at 25°C, pH 7.4 | Rattus norvegicus | |
0.18 | - |
2-deoxy-D-glucose | HKI, at 25°C, pH 7.4 | Rattus norvegicus | |
0.613 | - |
2-deoxy-D-glucose | HKII, at 25°C, pH 7.4 | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + ATP | Homo sapiens | glucose metabolism | D-glucose 6-phosphate + ADP | - |
? | |
D-glucose + ATP | Rattus norvegicus | glucose metabolism | D-glucose 6-phosphate + ADP | - |
? | |
D-glucose + ATP | Bos taurus | glucose metabolism | D-glucose 6-phosphate + ADP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
hexokinase I | - |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
hexokinase type II | - |
Rattus norvegicus | - |
hexokinase type I | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | hexokinase I: predominant in normal brain, hexokinase II: increased in brain tumors, ethylnitrosourea-induced 36B-10 astrocytic F-344 rat brain tumor cell line | Rattus norvegicus | - |
glioma cell | hexokinase I, predominant in normal brain | Rattus norvegicus | - |
glioma cell | hexokinase I, predominant in normal brain | Bos taurus | - |
glioma cell | hexokinase II, increased in brain tumors, ethylnitrosourea-induced 36B-10 astrocytic F-344 rat brain tumor cell line | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-fluoro-2-deoxy-D-glucose + ATP | - |
Rattus norvegicus | 2-fluoro-2-deoxy-D-glucose 6-phosphate + ADP | - |
? | |
2-fluoro-2-deoxy-D-glucose + ATP | - |
Bos taurus | 2-fluoro-2-deoxy-D-glucose 6-phosphate + ADP | - |
? | |
ATP + 2-deoxy-D-glucose | - |
Homo sapiens | ADP + 2-deoxy-D-glucose 6-phosphate | - |
? | |
ATP + 2-deoxy-D-glucose | - |
Rattus norvegicus | ADP + 2-deoxy-D-glucose 6-phosphate | - |
? | |
ATP + 2-deoxy-D-glucose | - |
Bos taurus | ADP + 2-deoxy-D-glucose 6-phosphate | - |
? | |
D-glucose + ATP | - |
Homo sapiens | ADP + D-glucose 6-phosphate | - |
? | |
D-glucose + ATP | - |
Rattus norvegicus | ADP + D-glucose 6-phosphate | - |
? | |
D-glucose + ATP | - |
Bos taurus | ADP + D-glucose 6-phosphate | - |
? | |
D-glucose + ATP | glucose metabolism | Homo sapiens | D-glucose 6-phosphate + ADP | - |
? | |
D-glucose + ATP | glucose metabolism | Rattus norvegicus | D-glucose 6-phosphate + ADP | - |
? | |
D-glucose + ATP | glucose metabolism | Bos taurus | D-glucose 6-phosphate + ADP | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
25 | - |
assay at | Rattus norvegicus |
25 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
7.4 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus | |
ATP | - |
Bos taurus |