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Information on EC 2.7.11.13 - protein kinase C
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2.7.11.13 protein kinase CIUBMB Comments
A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters.
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Word Map
- 2.7.11.13
-
phorbol
- pma
- agonist
- phospholipase
- 13-acetate
- 12-myristate
- staurosporine
- diacylglycerols
- camp
- inositol
- endothelial
- phosphatidylinositol
- mapks
- forskolin
-
ionophore
- cyclase
- myristate
-
camp-dependent
- 12-o-tetradecanoylphorbol-13-acetate
- calmodulin
- angiotensin
-
mitogen
-
desensitization
-
arachidonic
-
contractile
-
depolarization
-
receptor-mediated
- synaptic
-
blocker
- prostaglandin
- myocytes
- pertussis
- 3-kinase
-
signal-regulated
- phosphoinositide
- erk
- thapsigargin
- c-fos
- genistein
- wortmannin
-
1,4,5-trisphosphate
-
muscarinic
- endothelin-1
- ionomycin
-
l-type
- carbachol
- sphingosine
- fmlp
-
metabotropic
-
fura-2
- molecular biology
- medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
protein kinase c, pkcalpha, pkc-alpha, pkc alpha, pkcepsilon, pkc-delta, pkczeta, pkc-epsilon, pkc delta, pkc-zeta, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Calcium-dependent protein kinase C
calcium-independent protein kinase C
-
EC 2.7.1.37
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-
formerly, part transferred
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epsilonPKC
-
-
-
-
PKC
PKC alpha
PKC betaII
PKC delta
PKC epsilon
PKC-alpha
PKC-delta
PKC-zeta
PKC1
PKCalpha
PKCbeta1
PKCbeta2
PKCbetaII
PKCdelta
PKCepsilon
PKCeta
PKCgamma
PKCtheta
PKCzeta
protein kinase C
protein kinase C alpha
protein kinase C delta
protein kinase C, alpha type
protein kinase C, beta type
protein kinase C, delta type
protein kinase C, epsilon type
protein kinase C, eta type
protein kinase C, gamma type
protein kinase C, iota type
protein kinase C, zeta type
protein kinase C-like
protein kinase C-like 1
protein kinase C-like 2
protein kinase Calpha
protein kinase Cdelta
protein kinase-C
additional information
Calcium-dependent protein kinase C
-
-
-
-
PKC
-
-
-
-
PKC
-
-
PKC
-
-
PKC
-
-
protein kinase C
-
-
-
-
protein kinase C, beta type
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protein kinase C, delta type
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protein kinase-C
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-
-
-
additional information
the enzyme belongs to the family of serine/threonine kinases
additional information
-
PKC occurs in multiple isozymes, designated as classical, novel, and atypical isozymes, belonging to the PKC family
additional information
-
PKCs form a family of related serine/threonine kinases that are part of the AGC-type kinase, kinase G/protein kinase C-family kinase, superfamily
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (diacylglycerol-dependent)
A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters.
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CAS REGISTRY NUMBER
COMMENTARY
141436-78-4
calcium-dependent protein kinase C
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alphatomega peptide + ATP
ADP + phosphorylated-alphatomega peptide
-
an improved PKCalpha-responsive polyion complex (PIC) to measure PKCalpha activity is reported. The polycation molecule is the poly(amidoamine) (PAMAM) dendrimer modified with both cationic PKCalpha-specific peptide substrates (alphatomega, FKKQGSFAKKK-NH2) and near infrared (NIR) fluorophores (Cy5.5), and the polyanion molecule is the quencher (BHQ-3)-modified chondroitin sulfate
-
-
?
Arg-Phe-Ala-Arg-Lys-Gly-Ser-Leu-Arg-Gln-Lys-Asn-Val + ATP
Arg-Phe-Ala-Arg-Lys-Gly-phosphoSer-Leu-Arg-Gln-Lys-Asn-Val + ADP
-
-
-
-
?
ATP + calcium-activated potassium channel alpha subunit Slo1
ADP + phosphorylated calcium-activated potassium channel alpha subunit Slo1
-
-
-
-
?
ATP + calcium-independent phospholipase A2
ADP + phosphorylated calcium-independent phospholipase A2
ATP + calmodulin
ADP + phosphorylated calmodulin
-
phosphorylation at Thr497 in the calmodulin-binding domain, binding is competitive to substrate endothelial nitric oxide synthase
-
-
?
ATP + CTP:phosphoethanolamine cytidylyltransferase
ADP + phosphorylated CTP:phosphoethanolamine cytidylyltransferase
-
phosphorylation at Ser215 and Ser223
-
-
?
ATP + EF factor 1
ADP + phosphorylated EF factor 1
-
i.e. eukaryotic translation elongation factor 1-alpha1, in vitro phosphorylation
-
-
?
ATP + endothelial nitric oxide synthase
ADP + phosphorylated endothelial nitric oxide synthase
ATP + extracellular signal-regulated kinase 2
ADP + phosphorylated extracellular signal-regulated kinase 2
-
-
-
-
?
ATP + extracellular signal-related kinase
ADP + phosphorylated extracellular signal-related kinase
-
-
-
-
?
ATP + FKKQGSFAKKK
ADP + phosphorylated FKKQGSFAKKK
highly specific substrate for isozyme PKCalpha relative to other isozymes, 60% phosphorylation rate with isozyme PKCalpha, less than 20% phosphorylation rate with other PKC isozymes
-
-
?
ATP + Fyn
ADP + phosphorylated Fyn
-
Fyn is a tyrosine protein kinase of the Src family, phosphorylation at a serine residue
-
-
?
ATP + Galpha-interacting, vesicle-associated protein
ADP + phosphorylated-Galpha-interacting, vesicle-associated protein
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PKCtheta, down-regulates Galpha-interacting, vesicle-associated protein (GIV's) guanine exchange factor, GEF function by phosphorylating Ser-1689 located within GIV's GEF motif. PKCtheta specifically binds and phosphorylates GIV at S1689, and this phosphoevent abolishes GIV's ability to bind and activate trimeric G proteins Galphai
-
-
?
ATP + GluR6 kainate receptor subunit
ADP + phosphorylated GluR6 kainate receptor subunit
-
two specific residues on the GluR6 C terminus, Ser846 and Ser868, are phosphorylated by protein kinase C, PKC phosphorylation of GluR6 retains GluR6 in the endoplasmic reticulum
-
-
?
ATP + glycine transporter 2
ADP + phosphorylated glycine transporter 2
-
-
-
-
?
ATP + hematopoietic-specific G-protein Galpha15
ADP + phosphorylated hematopoietic-specific G-protein Galpha15
-
recombinant substrate expressed in COS-7 cells, phosphorylation at Ser334, mutant G-protein Galpha15 S334A is inactive as substrate for PKC
-
-
?
ATP + hematopoietic-specific G-protein Galpha15 peptide
ADP + phosphorylated hematopoietic-specific G-protein Galpha15 peptide
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the PKC phosphorylation site peptide sequence RKGSR includes Ser334
-
-
?
ATP + hematopoietic-specific G-protein Galpha16
ADP + phosphorylated hematopoietic-specific G-protein Galpha16
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substrate from HL-60 cells, phosphorylation at Ser336, mutant G-protein Galpha16 S336A is inactive as substrate for PKC
-
-
?
ATP + hematopoietic-specific G-protein Galpha16 peptide
ADP + phosphorylated hematopoietic-specific G-protein Galpha16 peptide
-
the PKC phosphorylation site peptide sequence KKGARSRR includes Ser336
-
-
?
ATP + histone H1-IIIS
ADP + phosphorylated histone H1-IIIS
isozyme PKCbeta
-
-
?
ATP + histone H2
ADP + phosphorylated histone H2
-
in vitro phosphorylation
-
-
?
ATP + histone H3
ADP + phosphorylated histone H3
-
in vitro phosphorylation
-
-
?
ATP + histone III-SS
ADP + phosphorylated histone III-SS
-
commercial substrate
-
-
?
ATP + histone IIIS
ADP + phosphorylated histone IIIS
poor substrate
-
-
?
ATP + hyperpolarization-activated cyclic nucleotide-gated channel 1 protein
ADP + phosphorylated hyperpolarization-activated cyclic nucleotide-gated channel 1 protein
-
-
-
-
?
ATP + inhibitory killer cell Ig-like receptor
ADP + phosphorylated inhibitory killer cell Ig-like receptor
ATP + insulin receptor substrate-3
ADP + phosphorylated insulin receptor substrate-3
-
-
-
?
ATP + insulin receptor substrate-4
ADP + phosphorylated insulin receptor substrate-4
-
-
-
?
ATP + lamin A
ADP + phosphorylated lamin A
-
a nuclear membrane protein, isozyme PKCalpha
-
-
?
ATP + lamin C
ADP + phosphorylated lamin C
-
a nuclear membrane protein, isozyme PKCalpha, phosphorylation at Ser572
-
-
?
ATP + metabotropic glutamate receptor 5
ADP + phosphorylated metabotropic glutamate receptor 5
ATP + mutant protein p22phox(P156Q)
ADP + phosphorylated mutant protein p22phox(P156Q)
-
-
-
-
?
ATP + mutant protein p22phox(T132A)
ADP + phosphorylated mutant protein p22phox(T132A)
-
-
-
-
?
ATP + myristoylated alanine-rich C kinase substrate
ADP + phosphorylated myristoylated alanine-rich C kinase substrate
ATP + myristoylated alanine-rich C-kinase (152-164)
ADP + phosphorylated myristoylated alanine-rich C-kinase (152-164)
-
-
-
-
?
ATP + phosphoinositide-dependent kinase
ADP + phosphorylated phosphoinositide-dependent kinase
ATP + phospholipase D1
ADP + phosphorylated phospholipase D1