Activating Compound | Comment | Organism | Structure |
---|---|---|---|
radiation | increases caspase-8 expression and activity | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | caspase-8 activation mediates p53-independent apoptosis of glioma cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
IETD-fmk | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q14790 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | no change in activity after irradiation | Homo sapiens | - |
glioma cell | - |
Homo sapiens | - |
SF-188 cell | increase in caspase-8 transcript levels and activity after irradiation | Homo sapiens | - |
U-251 MG cell | increase in caspase-8 transcript levels and activity after irradiation | Homo sapiens | - |
U-87MG cell | no change in activity after irradiation | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IETD-7-amido-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | IETD + 7-amino-4-trifluoromethylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
caspase-8 | - |
Homo sapiens |