Literature summary for 3.4.22.1 extracted from

Hwang, S.Y.; Yoo, B.C.; Jung, J.W.; Oh, E.S.; Hwang, J.S.; Shin, J.A.; Kim, S.Y.; Cha, S.H.; Han, I.O.
Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B (2009), Biochim. Biophys. Acta, 1793, 1656-1668.

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Inhibitors

Inhibitors	Comment	Organism	Structure
CA-074-Me	suppresses microglia conditioned culture medium-induced glioma cell death	Homo sapiens
CA-074-Me	suppresses microglia conditioned culture medium-induced glioma cell death	Rattus norvegicus
N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone	-	Homo sapiens
N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone	-	Rattus norvegicus
trans-epoxysuccinyl-leucylamido(4-guanidino)butane	-	Homo sapiens
trans-epoxysuccinyl-leucylamido(4-guanidino)butane	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	secreted by microglia	Homo sapiens	-	-
extracellular	secreted by microglia	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C6 glioma cell	-	Rattus norvegicus	-
commercial preparation	-	Homo sapiens	-
commercial preparation	-	Rattus norvegicus	-
glioma cell	astrocytic	Homo sapiens	-
glioma cell	astrocytic	Rattus norvegicus	-
microglia	-	Homo sapiens	-
microglia	primary	Rattus norvegicus	-
U-373MG cell	glioma cell line	Homo sapiens	-
U-87MG cell	glioma cell line	Homo sapiens	-

General Information

General Information	Comment	Organism
malfunction	Microglia induce apoptosis of glioma cells via the release of NO and cathepsin B protease. Cathepsin B causes a decrease in cell survival. Cathepsin B plays a critical role in cytotoxicity in the central nervous system	Homo sapiens
malfunction	Microglia induce apoptosis of glioma cells via the release of NO and cathepsin B protease. Cathepsin B causes a decrease in cell survival. Cathepsin B plays a critical role in cytotoxicity in the central nervous system	Rattus norvegicus

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Release 2023.1 (January 2023)