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Information on EC 3.4.22.1 - cathepsin B

for references in articles please use BRENDA:EC3.4.22.1

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IUBMB Comments

An intracellular (lysosomal) enzyme in peptidase family C1 (papain family)

The expected taxonomic range for this enzyme is: Eukaryota, Archaea
Reaction Schemes
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Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides

Synonyms
cathepsin b, cathepsin-b, cysteine cathepsin, devdase, cat b, cathepsin b1, cathb, smcb1, cath b, cath-b, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides
show the reaction diagram