Literature summary for 3.4.22.1 extracted from

Gray, J.; Haran, M.M.; Schneider, K.; Vesce, S.; Ray, A.M.; Owen, D.; White, I.R.; Cutler, P.; Davis, J.B.
Evidence that inhibition of cathepsin-B contributes to the neuroprotective properties of caspase inhibitor Tyr-Val-Ala-Asp-chloromethyl ketone (2001), J. Biol. Chem., 276, 32750-32755.

Search for more literature for 3.4.22.1

Application

Application	Comment	Organism
medicine	enzyme is involved in neuronal cell death, particularly following ischemia	Mus musculus
medicine	enzyme is involved in neuronal cell death, particularly following ischemia	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
acetyl-YVAD-chloromethyl ketone	caspase inhibitor, inhibition of enzyme contributes to neuroprotective properties of the inhibitor	Mus musculus
acetyl-YVAD-chloromethyl ketone	caspase inhibitor, inhibition of enzyme contributes to neuroprotective properties of the inhibitor	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebellum	cerebellar cultures	Rattus norvegicus	-
neuronal cell	-	Mus musculus	-

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Release 2023.1 (January 2023)