Protein Variants | Comment | Organism |
---|---|---|
additional information | cathepsin B deficiency inhibits pro-interleukin-1beta processing and maturation in microglia, no observable expression of the cleaved IL-1beta in the hippocampus of the aged CB-/- mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA-074-Me | a specific inhibitor, inhibits pro-interleukin-1beta processing in microglia | Mus musculus | |
E-64 | a broad cysteine protease inhibitor | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
additional information | subcellular localization study, overview | Mus musculus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
26000 | - |
x * 29000, mature cathepsin B, single-chain form, SDS-PAGE, x * 26000, mature cathepsin B, heavy-chain, SDS-PAGE | Mus musculus |
29000 | - |
x * 29000, mature cathepsin B, single-chain form, SDS-PAGE, x * 26000, mature cathepsin B, heavy-chain, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57/Bl mice | - |
Mus musculus C57/Bl | - |
C57/Bl mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
microglia | isolated from the mixed primary cell cultures from the cerebral cortex of 3-day-old wild-type or CB-/- mice, activated by chromogranin A | Mus musculus | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 29000, mature cathepsin B, single-chain form, SDS-PAGE, x * 26000, mature cathepsin B, heavy-chain, SDS-PAGE | Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | chromogranin A markedly induces cathepsin B at both protein and mRNA levels, determined by real-time quantitative RT-PCR | up |
General Information | Comment | Organism |
---|---|---|
physiological function | cathepsin B is required for interleukin-1beta maturation, the maturation of pro-IL-1beta in chromogranin A-stimulated microglia is dependent on the enzymatic activities of both cathepsin B and caspase-1 | Mus musculus |